LKT Labs

Biochemicals for Life Science Research

Clemizole

Clemizole

Product ID C4417
Cas No. 442-52-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $72.00 In stock
5 mg $101.00 In stock
10 mg $152.00 In stock
25 mg $313.00 In stock
Bulk Quote

Quicklinks

Description

Clemizole inhibits transient receptor potential cation 5 (TRPC5) channels. Clemizole also suppresses replication of hepatitis C virus (HCV) by inhibiting NS4B activity. This compound displays a wide variety of biological activities, including antiviral, anticonvulsant, antiepileptic, and anti-allergic properties. In vivo, clemizole prevents the development of seizures and decreases convulsive behaviors. This compound also may inhibit histamine H1 receptors, suppressing histamine activity.

Product Info

Cas No.

442-52-4
Purity

≥98%
Formula

C19H20ClN3
Formula Wt.

325.84
IUPAC Name

1-(4-Chlorobenzyl)-2-(1-pyrrolidinylmethyl)-1H-benzimidazole
Synonym

NSC46261, CID2782
Solubility

18mg/mL in DMSO 2mg/mL in Water

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

C4417 MSDS PDF
Info Sheet

C4417 Info Sheet PDF
Brochures

TRP Channel Modulator Flyer

References

Richter JM, Schaefer M, Hill K. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21. PMID: 25140002.

Baraban SC, Dinday MT, Hortopan GA. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nat Commun. 2013;4:2410. PMID: 24002024.

Einav S, Sobol HD, Gehrig E, et al. The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors. J Infect Dis. 2010 Jul 1;202(1):65-74. PMID: 20486856.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • R3477

    Ritodrine Hydrochloride

    Phenylethylamine; β2-adrenergic agonist, SK/BK...

    ≥98%
  • A3212

    3′-Azido-3′-deoxythymidine

    Nucleoside (thymidine) analog; DNA chain termin...

    ≥98%
  • I7258

    Isoflurane

    Ca2+ ATPase and ATP-sensitive K+ channel activa...

    ≥98%
  • T2817

    Theophylline

    Methylxanthine; PDE inhibitor, A1/2 adenosine a...

    ≥98%
  • E5219

    Endothelin-1, human

    Endogenous peptide involved in vascular contrac...

    ≥95%
  • I1257

    Idoxuridine

    Nucleoside (deoxyuridine) analog; DNA chain ter...

    ≥98%
  • M3379

    Mitoxantrone Dihydrochloride

    Anthracenedione, DNA intercalator; Pim-1 inhibi...

    ≥98%
  • T2834

    Thiolutin

    Dithiolopyrrolone; RNA polymerase inhibitor.

    ≥98%
  • H9661

    Hypocrellin A

    Prevents MHC II antigen presentation.

    ≥77%, contains ~16% B
  • B5000

    BMS-911543

    JAK2 inhibitor.

    ≥99%
  • D3431

    3,4-Dihydroxyphenyl Ethanol

    Polyphenol found in olive oil, antioxidant.

    ≥95%
  • I0516

    I-BET151

    BRD2/3/4 inhibitor.

    ≥98%
  • E6234

    Epigallocatechin Gallate

    Flavanol found in Camilla (green tea); AhR ant...

    ≥98%
  • T0114

    Taxinin M

    Taxane found in Taxus; DNA polymerase inhibitor...

    ≥98%
  • S5749

    Somatostatin-14

    Endogenous neuropeptide hormone; somatostatin a...

    ≥95%
  • T1012

    13-TES-Baccatin III

    Synthesis impurity

    ≥98%
  • W5769

    Wortmannin

    Steroid produced by Penicillum; PI3K, mTOR, DNA...

    ≥97%
  • S680017

    SR-717 Lithium Salt

    STING agonist

    ≥98%
  • P3076

    PHT-427

    PDK1 and Akt inhibitor.

    ≥98%
  • Z5744

    Zoledronic Acid Hydrate

    Bisphosphonate; FPPS inhibitor.

    ≥98%