LKT Labs

Biochemicals for Life Science Research

Clemizole

Product ID C4417
Cas No. 442-52-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $68.60 In stock
5 mg $96.40 In stock
10 mg $144.80 In stock
25 mg $297.60 In stock
Bulk Quote

Quicklinks

Description

Clemizole inhibits transient receptor potential cation 5 (TRPC5) channels. Clemizole also suppresses replication of hepatitis C virus (HCV) by inhibiting NS4B activity. This compound displays a wide variety of biological activities, including antiviral, anticonvulsant, antiepileptic, and anti-allergic properties. In vivo, clemizole prevents the development of seizures and decreases convulsive behaviors. This compound also may inhibit histamine H1 receptors, suppressing histamine activity.

Product Info

Cas No.

442-52-4
Purity

≥98%
Formula

C19H20ClN3
Formula Wt.

325.84
IUPAC Name

1-(4-Chlorobenzyl)-2-(1-pyrrolidinylmethyl)-1H-benzimidazole
Synonym

NSC46261, CID2782
Solubility

18mg/mL in DMSO 2mg/mL in Water

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

C4417 MSDS PDF
Info Sheet

C4417 Info Sheet PDF
Brochures

TRP Channel Modulator Flyer

References

Richter JM, Schaefer M, Hill K. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21. PMID: 25140002.

Baraban SC, Dinday MT, Hortopan GA. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nat Commun. 2013;4:2410. PMID: 24002024.

Einav S, Sobol HD, Gehrig E, et al. The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors. J Infect Dis. 2010 Jul 1;202(1):65-74. PMID: 20486856.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A064766

    ABT 639

    T-type calcium channel blocker

    ≥99%
  • N1769

    Nerolidol, synthetic

    AChE inhibitor, F0F1-ATP synthase modulator.

    A mixture of cis and trans isomers, ≥96%
  • B030967

    BAY-1895344

    ATR inhibitor.

    ≥99%
  • L9600

    LY-2090314

    GSK-3 inhibitor.

    ≥98%
  • A1592

    ADX-47273

    mGluR5 positive modulator.

    ≥98%
  • I7259

    Isoproterenol Hydrochloride

    β-adrenergic agonist.

    ≥98%
  • T1002

    2-Debenzoyl Paclitaxel-2-(2-Methyl-2-Butenoate)

    Synthesis intermediate

    ≥95%
  • S0168

    Saracatinib

    Src and Abl inhibitor.

    ≥98%
  • P8118

    Puerarin

    Isoflavone daidzein derivative found in Puerari...

    ≥96%
  • L5749

    Lomefloxacin Hydrochloride

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • C0273

    Casin

    Cdc42 GTPase inhibitor.

    ≥97%
  • D0368

    2-Epi-16-deoxysarcophine

    Cembranoid found in Sarcophyton.

    ≥98%
  • S7603

    Stavudine

    Nucleoside (thymidine) analog; DNA chain termin...

    ≥99%
  • O9210

    Oxcarbazepine

    α4β2 nAChR desensitizer, delayed-rectifier vo...

    ≥98%
  • T8020

    Tuftsin

    Tetrapeptide, IgG Fc region derivative; Nrp1 ag...

    ≥95%
  • D1761

    15-Acetyl-deoxynivalenol

    Type A trichothecene mycotoxin produced by Fusa...

    ≥98%, TLC
  • N0069

    Naringin

    Flavanone glycoside found in citrus fruit; SERM...

    ≥97%
  • D5692

    Doxifluridine

    5-Fluorouracil prodrug, pyrimidine nucleoside a...

    ≥98%
  • G7442

    GSK-343

    EZH2 HMT inhibitor.

    ≥98%
  • N1987

    Neuropeptide Y (13-36), human

    Endogenous peptide neurotransmitter, involved i...

    ≥95%