LKT Labs

Biochemicals for Life Science Research

Clemizole

Clemizole

Product ID C4417
Cas No. 442-52-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $72.00 In stock
5 mg $101.00 In stock
10 mg $152.00 In stock
25 mg $313.00 In stock
Bulk Quote

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Description

Clemizole inhibits transient receptor potential cation 5 (TRPC5) channels. Clemizole also suppresses replication of hepatitis C virus (HCV) by inhibiting NS4B activity. This compound displays a wide variety of biological activities, including antiviral, anticonvulsant, antiepileptic, and anti-allergic properties. In vivo, clemizole prevents the development of seizures and decreases convulsive behaviors. This compound also may inhibit histamine H1 receptors, suppressing histamine activity.

Product Info

Cas No.

442-52-4
Purity

≥98%
Formula

C19H20ClN3
Formula Wt.

325.84
IUPAC Name

1-(4-Chlorobenzyl)-2-(1-pyrrolidinylmethyl)-1H-benzimidazole
Synonym

NSC46261, CID2782
Solubility

18mg/mL in DMSO 2mg/mL in Water

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

C4417 MSDS PDF
Info Sheet

C4417 Info Sheet PDF
Brochures

TRP Channel Modulator Flyer

References

Richter JM, Schaefer M, Hill K. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21. PMID: 25140002.

Baraban SC, Dinday MT, Hortopan GA. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nat Commun. 2013;4:2410. PMID: 24002024.

Einav S, Sobol HD, Gehrig E, et al. The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors. J Infect Dis. 2010 Jul 1;202(1):65-74. PMID: 20486856.

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