LKT Labs

Biochemicals for Life Science Research

Clemizole

Clemizole

Product ID C4417
Cas No. 442-52-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $72.00 In stock
5 mg $101.20 In stock
10 mg $152.00 In stock
25 mg $312.50 In stock
Bulk Quote

Quicklinks

Description

Clemizole inhibits transient receptor potential cation 5 (TRPC5) channels. Clemizole also suppresses replication of hepatitis C virus (HCV) by inhibiting NS4B activity. This compound displays a wide variety of biological activities, including antiviral, anticonvulsant, antiepileptic, and anti-allergic properties. In vivo, clemizole prevents the development of seizures and decreases convulsive behaviors. This compound also may inhibit histamine H1 receptors, suppressing histamine activity.

Product Info

Cas No.

442-52-4
Purity

≥98%
Formula

C19H20ClN3
Formula Wt.

325.84
IUPAC Name

1-(4-Chlorobenzyl)-2-(1-pyrrolidinylmethyl)-1H-benzimidazole
Synonym

NSC46261, CID2782
Solubility

18mg/mL in DMSO 2mg/mL in Water

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

C4417 MSDS PDF
Info Sheet

C4417 Info Sheet PDF
Brochures

TRP Channel Modulator Flyer

References

Richter JM, Schaefer M, Hill K. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21. PMID: 25140002.

Baraban SC, Dinday MT, Hortopan GA. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nat Commun. 2013;4:2410. PMID: 24002024.

Einav S, Sobol HD, Gehrig E, et al. The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors. J Infect Dis. 2010 Jul 1;202(1):65-74. PMID: 20486856.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • F1655

    Fenoprofen Calcium Dihydrate

    NSAID; COX-1/2 inhibitor.

    ≥97%
  • N8460

    NVP-BHG712

    EphB4 inhibitor.

    ≥98%
  • C0273

    Casin

    Cdc42 GTPase inhibitor.

    ≥97%
  • S8169

    Suramin Hexasodium

    RyR agonist, SIRT, telomerase, P2Y, GPCR inhibi...

    ≥98%
  • C0169

    Carbenoxolone Disodium

    Synthetic derivative of glycyrrhizin; connexin ...

    ≥97%
  • D023721

    Dasatinib

    Multikinase inhibitor.

    ≥99%
  • T2930

    Thiabendazole

    Benzimidazole; microtubule polymerization inhib...

    ≥98%
  • G7442

    GSK-343

    EZH2 HMT inhibitor.

    ≥98%
  • A7202

    AS-604850

    p110γ PI3K inhibitor.

    ≥98%
  • D582703

    Dorsomorphin

    Inhibitor of ALK2, ALK3, ALK6, and AMPK.

    ≥98%
  • P0268

    Parasin I

    Histone H2-derived antimicrobial peptide found ...

    ≥95%
  • M1646

    Melanin Concentrating Hormone, human/mouse/rat

    Endogenous peptide hormon involved in energy ho...

    ≥98%
  • S020665

    Saquinavir

    Protease inhibitor

    ≥99%
  • A4534

    Aliskiren Hemifumarate

    Renin inhibitor.

    ≥98%
  • R1724

    Regadenoson

    Adenosine A2A agonist.

    ≥99%
  • P9200

    PX-866

    Wortmannin analog; PI3K inhibitor.

    ≥98%
  • N4524

    NLG919

    Indoleamine-2,3-dioxygenase inhibitor.

    ≥98%
  • B1979

    Betulinic Acid

    Pentacyclic triterpene.

    ≥99%
  • G733409

    GSK-2982772

    RIP1 inhibitor.

    ≥98%
  • P7103

    Praziquantel

    Alters membrane permeability and Ca2+ signaling...

    ≥98%