LKT Labs

Biochemicals for Life Science Research

Clemizole

Clemizole

Product ID C4417
Cas No. 442-52-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $72.00 In stock
5 mg $101.00 In stock
10 mg $152.00 In stock
25 mg $313.00 In stock
Bulk Quote

Quicklinks

Description

Clemizole inhibits transient receptor potential cation 5 (TRPC5) channels. Clemizole also suppresses replication of hepatitis C virus (HCV) by inhibiting NS4B activity. This compound displays a wide variety of biological activities, including antiviral, anticonvulsant, antiepileptic, and anti-allergic properties. In vivo, clemizole prevents the development of seizures and decreases convulsive behaviors. This compound also may inhibit histamine H1 receptors, suppressing histamine activity.

Product Info

Cas No.

442-52-4
Purity

≥98%
Formula

C19H20ClN3
Formula Wt.

325.84
IUPAC Name

1-(4-Chlorobenzyl)-2-(1-pyrrolidinylmethyl)-1H-benzimidazole
Synonym

NSC46261, CID2782
Solubility

18mg/mL in DMSO 2mg/mL in Water

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

C4417 MSDS PDF
Info Sheet

C4417 Info Sheet PDF
Brochures

TRP Channel Modulator Flyer

References

Richter JM, Schaefer M, Hill K. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21. PMID: 25140002.

Baraban SC, Dinday MT, Hortopan GA. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nat Commun. 2013;4:2410. PMID: 24002024.

Einav S, Sobol HD, Gehrig E, et al. The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors. J Infect Dis. 2010 Jul 1;202(1):65-74. PMID: 20486856.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C2948

    Chloroadenosine

    Nucleoside (adenosine) analog; DNA chain termin...

    ≥98%
  • S0133

    Saikosaponin C

    Triterpene saponin found in Bupleurum.

    ≥98%
  • C0267

    Carnosol

    Diterpene compound originally found in Rosmarin...

    ≥98%
  • F4432

    FLI-06

    Notch inhibitor.

    ≥99%
  • D604080

    DpC

    Anti-metastatic

    ≥99%
  • A1616

    AEE-788

    Inhibitor of EGFR, HER2, VEGFR2, and FLT3.

    ≥98%
  • E6997

    Erythropoietin, Human Recombinant

    Endogenous glycoprotein hormone involved in red...

    ≥97%
  • G1658

    Gentamycin Sulfate

    Aminoglycoside; protein translation inhibitor.<...
  • P327211

    Pifithrin-α Hydrobromide

    p53 inhibitor

    ≥98%
  • T7035

    Triptolide

    Diterpenoid epoxide found in Tripterygium.

    ≥98%
  • M184790

    Metyrapone

    Steroidogenesis inhibitor

    ≥98%
  • A7577

    Astilbin

    Flavonoid found in various plant sources.

    ≥99%
  • C0155

    10-Hydroxycamptothecin

    Camptothecin derivative; topoisomerase I inhibi...

    ≥98%
  • R1860

    Repaglinide

    Sulfonylurea; ATP-sensitive K+ channel blocker....

    ≥98%
  • N5769

    Norfloxacin Nicotinate

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • D0169

    Darifenacin Hydrobromide

    M3 mAChR antagonist.

    ≥98%
  • B1640

    Benzydamine Hydrochloride

    NSAID; PG synthetase inhibitor.

    ≥98%
  • C4532

    Clindamycin Hydrochloride

    Lincosamide; ribosomal translocation and protei...

    ≥98%
  • T2936

    Thioridazine Hydrochloride

    Piperadine phenothiazine; FIASMA, D1-5, histami...

    ≥98%
  • M2076

    Metformin Hydrochloride

    AMPK activator.

    ≥98%