LKT Labs

Biochemicals for Life Science Research

Clemizole

Clemizole

Product ID C4417
Cas No. 442-52-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $72.00 In stock
5 mg $101.20 In stock
10 mg $152.00 In stock
25 mg $312.50 In stock
Bulk Quote

Quicklinks

Description

Clemizole inhibits transient receptor potential cation 5 (TRPC5) channels. Clemizole also suppresses replication of hepatitis C virus (HCV) by inhibiting NS4B activity. This compound displays a wide variety of biological activities, including antiviral, anticonvulsant, antiepileptic, and anti-allergic properties. In vivo, clemizole prevents the development of seizures and decreases convulsive behaviors. This compound also may inhibit histamine H1 receptors, suppressing histamine activity.

Product Info

Cas No.

442-52-4
Purity

≥98%
Formula

C19H20ClN3
Formula Wt.

325.84
IUPAC Name

1-(4-Chlorobenzyl)-2-(1-pyrrolidinylmethyl)-1H-benzimidazole
Synonym

NSC46261, CID2782
Solubility

18mg/mL in DMSO 2mg/mL in Water

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

C4417 MSDS PDF
Info Sheet

C4417 Info Sheet PDF
Brochures

TRP Channel Modulator Flyer

References

Richter JM, Schaefer M, Hill K. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21. PMID: 25140002.

Baraban SC, Dinday MT, Hortopan GA. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nat Commun. 2013;4:2410. PMID: 24002024.

Einav S, Sobol HD, Gehrig E, et al. The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors. J Infect Dis. 2010 Jul 1;202(1):65-74. PMID: 20486856.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A0968

    Adrenocorticotropic Hormone (1-24), human

    Endogenous peptide hormone fragment, involved i...

    ≥95%
  • S0501

    SB-939

    HDAC inhibitor.

    ≥98%
  • P200637

    PF-04745637

    TRPA1 antagonist

    ≥98%
  • K0032

    Kahweol Palmitate

    Diterpene found in coffee beans.

    ≥97%
  • A9834

    Azithromycin Dihydrate

    Azalide macrolide; protein translation inhibito...

    ≥98%
  • T1679

    Tetracycline Hydrochloride

    Polyketide; protein translation inhibitor, mamm...

    ≥95%
  • P1761

    Pepstatin

    Aspartyl protease inhibitor.

    ≥98%
  • L0251

    Laminin Peptide CDPGYIGSR

    Laminin-derived nonapeptide.

    ≥98%
  • N0161

    β-Naphthoflavone

    AhR agonist.

    ≥98%
  • L8278

    Luteinizing Hormone Releasing Hormone, salmon

    Endogenous peptide hormone, involved in secreti...

    ≥95%
  • M184770

    4-O-Methylhonokiol

    Found in Magnolia officinalis.

    ≥98%
  • P0110

    (R)-P7C3-OMe

    Methoxy aminopropyl carbazole, neuroprotective....

    ≥98%
  • M0126

    Magainin 2

    Antimicrobial peptide found in frogs, induces p...

    ≥95%
  • T2932

    Thiamphenicol Glycinate Hydrochloride

    Chloramphenicol derivative; protein translation...

    ≥98%
  • P9870

    Pyridostatin Hydrochloride

    G-quadruplex ligand; DNA breakage inducer.

    ≥97%
  • T1298

    TDZD-8

    GSK-3β inhibitor.

    ≥98%
  • R7680

    Recombinant M. Tuberculosis Antigen TB 38+6+10

    Tuberculosis antigen
  • T165131

    Tedizolid

    Effective against gram-positive pathogens

    ≥98%
  • D183738

    19-O-Demethyl rapamycin

    Fermentation impurity

    ≥97%
  • A7333

    Asiaticoside

    Triterpene found in Centella, prevents melanoge...

    ≥90%