Clemizole

Name: Clemizole
SKU: C4417
Availability: InStock

Product ID C4417

Cas No. 442-52-4

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Clemizole inhibits transient receptor potential cation 5 (TRPC5) channels. Clemizole also suppresses replication of hepatitis C virus (HCV) by inhibiting NS4B activity. This compound displays a wide variety of biological activities, including antiviral, anticonvulsant, antiepileptic, and anti-allergic properties. In vivo, clemizole prevents the development of seizures and decreases convulsive behaviors. This compound also may inhibit histamine H1 receptors, suppressing histamine activity.

Product Info

Cas No.	442-52-4
Purity	≥98%
Formula	C₁₉H₂₀ClN₃
Formula Wt.	325.84
IUPAC Name	1-(4-Chlorobenzyl)-2-(1-pyrrolidinylmethyl)-1H-benzimidazole
Synonym	NSC46261, CID2782
Solubility	18mg/mL in DMSO 2mg/mL in Water

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	C4417 MSDS PDF
Info Sheet	C4417 Info Sheet PDF
Brochures	TRP Channel Modulator Flyer

References

Richter JM, Schaefer M, Hill K. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21. PMID: 25140002.

Baraban SC, Dinday MT, Hortopan GA. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nat Commun. 2013;4:2410. PMID: 24002024.

Einav S, Sobol HD, Gehrig E, et al. The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors. J Infect Dis. 2010 Jul 1;202(1):65-74. PMID: 20486856.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Comments
This field is for validation purposes and should be left unchanged.

Clemizole

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Lamotrigine

Diaveridine Hydrochloride

Prostaglandin E2

Bactenecin

MLN2480

Verbascoside

Clioquinol

Rosuvastatin Calcium

Foscarnet Sodium Hydrate

Guanylin, human

C59

Vidarabine Monophosphate

IC261

Evacetrapib

Camalexin

Catharanthine Tartrate

Fulvestrant

Flibanserin

Milrinone

AS-605240

Footer