LKT Labs

Biochemicals for Life Science Research

Clemizole

Clemizole

Product ID C4417
Cas No. 442-52-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $72.00 In stock
5 mg $101.20 In stock
10 mg $152.00 In stock
25 mg $312.50 In stock
Bulk Quote

Quicklinks

Description

Clemizole inhibits transient receptor potential cation 5 (TRPC5) channels. Clemizole also suppresses replication of hepatitis C virus (HCV) by inhibiting NS4B activity. This compound displays a wide variety of biological activities, including antiviral, anticonvulsant, antiepileptic, and anti-allergic properties. In vivo, clemizole prevents the development of seizures and decreases convulsive behaviors. This compound also may inhibit histamine H1 receptors, suppressing histamine activity.

Product Info

Cas No.

442-52-4
Purity

≥98%
Formula

C19H20ClN3
Formula Wt.

325.84
IUPAC Name

1-(4-Chlorobenzyl)-2-(1-pyrrolidinylmethyl)-1H-benzimidazole
Synonym

NSC46261, CID2782
Solubility

18mg/mL in DMSO 2mg/mL in Water

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

C4417 MSDS PDF
Info Sheet

C4417 Info Sheet PDF
Brochures

TRP Channel Modulator Flyer

References

Richter JM, Schaefer M, Hill K. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21. PMID: 25140002.

Baraban SC, Dinday MT, Hortopan GA. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nat Commun. 2013;4:2410. PMID: 24002024.

Einav S, Sobol HD, Gehrig E, et al. The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors. J Infect Dis. 2010 Jul 1;202(1):65-74. PMID: 20486856.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C4274

    CKS-17

    Synthetic peptide, retroviral envelope protein ...

    ≥95%
  • G3458

    Ginsenoside Rg1

    Triterpene saponin found in species of Panax.

    ≥98%
  • M1976

    Methimazole

    Thioamide; thyroid peroxidase inhibitor.

    ≥98%
  • H9716

    (E,Z)-4-Hydroxytamoxifen

    Selective estrogen receptor modulator.

    ≥97%
  • G4581

    Glucosamine Sulfate Potassium Chloride

    Endogenous amino acid sugar involved in cartila...

    ≥98%
  • P5745

    Polygalic Acid

    Saponin found in Polygala.

    ≥97%
  • O4533

    Oligomycin

    Mixture of oligomycins A, B, C; oxidative phosp...

    ≥97%
  • G3462

    Ginsenoside F3

    Triterpene saponin found in species of Panax.

    ≥98%
  • U682040

    URB597

    FAAH inhibitor.

    ≥98%
  • E5220

    Enfuvirtide (T-20)

    Synthetic peptide derived from HIV-1; viral fus...

    ≥95%
  • L930280

    LXH254

    pan-RAF inhibitor

    ≥99%
  • B6805

    Bradykinin (1-7)

    Natriuretic, vasodilatory peptide fragment; B1/...

    ≥95%
  • Z2268

    Z-FR-AMC

    Protease substrate.

    ≥95%
  • E622698

    Eprosartan Mesylate

    Nonpeptide angiotensin II receptor antagonist

    ≥99%
  • R5874

    Rosmarinic Acid

    Caffeic acid ester found in Melissa, Salvia, an...

    ≥98%
  • S1968

    Seratrodast

    TxA2 antagonist.

    ≥99%
  • A5059

    Amoxapine

    5-HT2/3/6/7, D2/3/4, histamine H1, α1-adrenerg...

    ≥98%
  • C8017

    Cuelure

    Hormonal attractant for male Bactrocera flies.<...

    ≥97%
  • A9814

    AZD-4547

    FGFR inhibitor.

    ≥98%
  • P1969

    Perifosine

    Alkylphospholipid analog; Akt inhibitor.

    ≥98%