Clozapine

Name: Clozapine
SKU: C4757
Availability: InStock

Product ID C4757

Cas No. 5786-21-0

Purity ≥97%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Clozapine is an atypical antipsychotic that also exhibits some immunosuppressive activity. Clozapine is clinically used to treat mood disorders. Clozapine binds Kv1.1 channels, prolonging the QT interval and also causes granulocytosis, limiting its clinical use. Clozapine acts as an antagonist at M1/2/3/5 muscarinic acetylcholine receptors (mAChRs) and D2 receptors, a partial agonist at 5-HT1A receptors, and as a full agonist at M4 mAChRs. Additionally, clozapine binds 5-HT2/3/6/7 receptors, D4 receptors, α1/2 adrenergic receptors, and histamine H1 receptors. Clozapine also potentiates GABAergic neurotransmission.

Product Info

Cas No.	5786-21-0
Purity	≥97%
Formula	C₁₈H₁₉ClN₄
Formula Wt.	326.82
Chemical Name	8-chloro-11-(4-methyl-1-piperazinyl)-5H-Dibenzo(b,e)(1,4)diazepine
IUPAC Name	3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine
Synonym	Clozaril, Leponex
Melting Point	183-184°C
Solubility	Soluble in DMSO or dilute aqueous acid.
Appearance	Yellow crystalline powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	C4757 MSDS PDF
Info Sheet	C4757 Info Sheet PDF

References

Hill AP, Perrin MJ, Heide J, et al. Kinetics of drug interaction with the Kv11.1 potassium channel. Mol Pharmacol. 2014 May;85(5):769-76. PMID: 24586056.

Tanahashi S, Yamamura S, Nakagawa M, et al. Clozapine, but not haloperidol, enhances glial D-serine and L-glutamate release in rat frontal cortex and primary cultured astrocytes. Br J Pharmacol. 2012 Mar;165(5):1543-55. PMID: 21880034.

Wu Y, Blichowski M, Daskalakis ZJ, et al. Evidence that clozapine directly interacts on the GABAB receptor. Neuroreport. 2011 Sep 14;22(13):637-41. PMID: 21753741.

Nord M, Farde L. Antipsychotic occupancy of dopamine receptors in schizophrenia. CNS Neurosci Ther. 2011 Apr;17(2):97-103. PMID: 21143431.

Alvir JM, Lieberman JA, Safferman AZ, et al. Clozapine-induced agranulocytosis. Incidence and risk factors in the United States. N Engl J Med. 1993 Jul 15;329(3):162-7. PMID: 8515788.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Email
This field is for validation purposes and should be left unchanged.

Clozapine

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Tobramycin, Free Base

Ethacridine Lactate Monohydrate

α-Melanocyte Stimulating Hormone

GSK-690693

S-(−)-Schisandrin B

Everolimus EP Impurity E

Terbutaline Sulfate

Vitexin

Lopinavir

MLN8237

Ibuprofen

LGK-974

Naringenin

GDC-6036

GNF-2

Hexestrol

AZD-9291

13-Acetyl-9-dihydrobaccatin-III

Pyrantel Pamoate

5-Fluorocytosine

Footer