LKT Labs

Biochemicals for Life Science Research

Clozapine

Clozapine

Product ID C4757
Cas No. 5786-21-0
Purity ≥97%
Product Unit SizeCostQuantityStock
25 mg $58.00 In stock
100 mg $97.00 In stock
250 mg $165.00 In stock
Bulk Quote

Quicklinks

Description

Clozapine is an atypical antipsychotic that also exhibits some immunosuppressive activity. Clozapine is clinically used to treat mood disorders. Clozapine binds Kv1.1 channels, prolonging the QT interval and also causes granulocytosis, limiting its clinical use. Clozapine acts as an antagonist at M1/2/3/5 muscarinic acetylcholine receptors (mAChRs) and D2 receptors, a partial agonist at 5-HT1A receptors, and as a full agonist at M4 mAChRs. Additionally, clozapine binds 5-HT2/3/6/7 receptors, D4 receptors, α1/2 adrenergic receptors, and histamine H1 receptors. Clozapine also potentiates GABAergic neurotransmission.

Product Info

Cas No.

5786-21-0
Purity

≥97%
Formula

C18H19ClN4
Formula Wt.

326.82
Chemical Name

8-chloro-11-(4-methyl-1-piperazinyl)-5H-Dibenzo(b,e)(1,4)diazepine

IUPAC Name

3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine
Synonym

Clozaril, Leponex
Melting Point

183-184°C
Solubility

Soluble in DMSO or dilute aqueous acid.

Appearance

Yellow crystalline powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

C4757 MSDS PDF
Info Sheet

C4757 Info Sheet PDF

References

Hill AP, Perrin MJ, Heide J, et al. Kinetics of drug interaction with the Kv11.1 potassium channel. Mol Pharmacol. 2014 May;85(5):769-76. PMID: 24586056.

Tanahashi S, Yamamura S, Nakagawa M, et al. Clozapine, but not haloperidol, enhances glial D-serine and L-glutamate release in rat frontal cortex and primary cultured astrocytes. Br J Pharmacol. 2012 Mar;165(5):1543-55. PMID: 21880034.

Wu Y, Blichowski M, Daskalakis ZJ, et al. Evidence that clozapine directly interacts on the GABAB receptor. Neuroreport. 2011 Sep 14;22(13):637-41. PMID: 21753741.

Nord M, Farde L. Antipsychotic occupancy of dopamine receptors in schizophrenia. CNS Neurosci Ther. 2011 Apr;17(2):97-103. PMID: 21143431.

Alvir JM, Lieberman JA, Safferman AZ, et al. Clozapine-induced agranulocytosis. Incidence and risk factors in the United States. N Engl J Med. 1993 Jul 15;329(3):162-7. PMID: 8515788.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T3324

    Tigecycline

    Glycylcycline; protein synthesis inhibitor.

    ≥98%
  • B8276

    Butyric Acid Sodium

    HDAC inhibitor, RNA splicing modulator.

    ≥98%
  • P698583

    Prostaglandin E2

    principal metabolic product of COX-2

    ≥98%
  • I5072

    Imazalil

    Triazole; 14-α demethylase and aromatase inhib...

    ≥95%, titration; ≥70%, HPLC
  • I7757

    Itopride Hydrochloride

    AChE inhibitor, D2 antagonist.

    ≥98%
  • D1849

    4′-Demethylepipodophyllotoxin

    Podophyllotoxin derivative found in Podophyllum...

    ≥98%
  • C9614

    Cyclosporin H

    Cyclosporin metabolite; formyl peptide inhibito...

    ≥96%
  • G124090

    GDC-6036

    KRAS inhibitor

    ≥98%
  • I7659

    1-Isothiocyanato-8-(methylsulfonyl)-octane

    ITC, erysolin analog.

    ≥98%
  • C5654

    Concanavalin A

    Lectin found in Canavelia, plant mitogen that b...
  • B465806

    BLU-667

    RET inhibitor.

    ≥98%
  • T0216

    TAE-226

    FAK inhibitor.

    ≥98%
  • T0118

    7-epi-Cephalomannine

    Cephalomannine derivative found in Taxus; poten...

    ≥95%
  • G1849

    Gemifloxacin Mesylate

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • R3321

    Rifaximin

    Rifampicin derivative; DNA-dependent RNA polyme...

    ≥98%
  • K9858

    Kyotorphin

    Opioid neuropeptide; kyotorphin agonist.

    ≥95%
  • T3203

    Tianeptine Sodium Hydrate

    μOR and δOR agonist, D2/D3 DA potentiator.

    ≥98%
  • D3329

    7,8-Dihydroxyflavone Hydrate

    TrkB agonist.

    ≥99%
  • E4785

    Elvitegravir

    Integrase inhibitor.

    ≥98%
  • D3301

    Diaveridine

    Coccidiostat; dihydrofolate reductase inhibitor...

    ≥98%