Concanamycin A

Name: Concanamycin A
SKU: C577524
Availability: InStock

Product ID C577524

Cas No. 80890-47-7

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Concanamycin A is an 18-membered macrolide lactone antibiotic produced by Streptomyces diastatochromogenes S45. Concanamycin A has shown fungicidal, larvicidal, and cytotoxic activities. In human oral squamous cell carcinoma cells, treatment with concanamycin A inhibited the acidification of vesicular organelles, inhibited proliferation, induced apoptosis, induced phosphorylation of p38, and increased the Bax/Bcl-2 ratio. Concanamycin A is known to be a specific inhibitor of vacuolar H+-ATPase.

Product Info

Cas No.	80890-47-7
Purity	≥98%
Formula	C₄₆H₇₅NO₁₄
Formula Wt.	866.10
Chemical Name	[(2R,3S,4R,6R)-6-[(2R,4R,5S,6R)-2-[(2S,3R,4S)-4-[(2R,3S,4E,6E,9R,10S,11S,12R,13R,14E,16Z)-11-ethyl-10,12-dihydroxy-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-4,6,14,16-tetraen-2-yl]-3-hydroxypentan-2-yl]-2-hydroxy-5-methyl-6-[(E)-prop-1-enyl]oxan-4-yl]oxy-4-hydroxy-2-methyloxan-3-yl] carbamate
IUPAC Name	[(2R,3S,4R,6R)-6-[(2R,4R,5S,6R)-2-[(2S,3R,4S)-4-[(2R,3S,4E,6E,9R,10S,11S,12R,13R,14E,16Z)-11-ethyl-10,12-dihydroxy-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-4,6,14,16-tetraen-2-yl]-3-hydroxypentan-2-yl]-2-hydroxy-5-methyl-6-[(E)-prop-1-enyl]oxan-4-yl]oxy-4-hydroxy-2-methyloxan-3-yl] carbamate
Synonym	Folimycin
Solubility	Soluble in water (partly), chloroform, ethanol, methanol, and DMSO.
Appearance	White powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	C577524 MSDS PDF
Info Sheet	C577524 Info Sheet PDF

References

Westley JW, Liu CM, Sello LH, et al. The structure and absolute configuration of the 18-membered macrolide lactone antibiotic X-4357B (concanamycin A). J Antibiot (Tokyo). 1984 Dec;37(12):1738-1740. PMID: 6526741

Kiyoshima T, Yoshida H, Wada H, et al. Chemoresistance to concanamycin A1 in human oral squamous cell carcinoma is attenuated by an HDAC inhibitor partly via suppression of Bcl-2 expression. PLoS One. 2013 Nov 20;8(11):e80998. PMID: 24278362

Yano K, Yanagisawa T, Mukae K, et al. Dissection of autophagy in tobacco BY-2 cells under sucrose starvation conditions using the vacuolar H(+)-ATPase inhibitor concanamycin A and the autophagy-related protein Atg8. Plant Signal Behav. 2015;10(11):e1082699. PMID: 26368310

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Name
This field is for validation purposes and should be left unchanged.

Concanamycin A

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

BMS-777607

Benzyl Selenocyanate

Cilostazol

Octopamine Hydrochloride

Secretin, rat

Butylated Hydroxyanisole

7-TES-Paclitaxel

(-)-Umbellulone

Maprotiline Hydrochloride

IPI-549

25-Hydroxyvitamin D2

Prednisone Acetate

Ginsenoside Rd

Substance P (1-7)

Carveol

Radicicol

Carcinoembryonic Antigen (605-613)

Cerebellin

HIV Reverse Transcriptase A2.1 Peptide

2-Methoxyestradiol

Footer