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Cyclosporin A is a cyclic peptide that exhibits immunosuppressive activity. Cyclosporin A is clinically used to prevent rejection in organ transplants and to treat or prevent graft-versus-host disease (GvHD). Cyclosporin A binds cyclophilin, inhibiting calcineurin and decreasing levels of IL-2 and activated T cells. Cyclosporin A also shows benefit in the treatment of traumatic brain injury.
| Cas No. | 59865-13-3 |
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| Purity | ≥98% |
| Formula | C62H111N11O12 |
| Formula Wt. | 1202.61 |
| IUPAC Name | (3S,6S,9S,12R,15S,18S,21R,24S,30S)-30-ethyl-33-[(E,1R, 2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,22,25, 28-decamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1, 4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17, 20,23,26,29,32-undecone |
| Synonym | Cyclosporine, Ciclosporin, Sandimmun, Neoral |
| Melting Point | 148-151°C |
| Solubility | Soluble in methanol, ethanol, acetone, ether or chloroform. Also soluble in DMSO (>50 mg/mL). Very slightly soluble in water. |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Lulic D, Burns J, Bae EC, et al. A review of laboratory and clinical data supporting the safety and efficacy of cyclosporin A in traumatic brain injury. Neurosurgery. 2011 May;68(5):1172-86. PMID: 21307793.
Reynolds NJ, Al-Daraji WI. Calcineurin inhibitors and sirolimus: mechanisms of action and applications in dermatology. Clin Exp Dermatol. 2002 Oct;27(7):555-61. PMID: 12464150.
Handschumacher RE, Harding MW, Rice J, et al. Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science. 1984 Nov 2;226(4674):544-7. PMID: 6238408.
Koseki N, Deguchi J, Yamashita A, et al. Establishment fo a novel experimental protocol for drug-induced seizure liability screening based on a locomotor activity assay in zebrafish. J Toxicol Sci. 2014 Aug;39(4):579-600. PMID: 25056783.