Description
Cyclosporin H is a cyclosporin metabolite that inhibits the formyl peptide receptor but not calmodulin. Cyclosporin H lacks immunosuppressive activity but inhibits basophil activation.
Cyclosporin H
Product ID C9614
Cas No. 83602-39-5
Purity ≥96%
| Product Unit Size | Cost | Quantity | Stock |
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Product Info
| Cas No. | 83602-39-5 |
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| Purity | ≥96% |
| Formula | C62H111N11O12 |
| Formula Wt. | 1202.61 |
| IUPAC Name | (3S,6S,9S,12R,15S,18S,21R,24S,30S)-30-ethyl-33-[(E,1R, 2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,22,25, 28-decamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1, 4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17, 20,23,26,29,32-undecone |
| Synonym | Csh cyclosporin, Cyclosporine H |
| Melting Point | 162-167°C |
| Solubility | Soluble in DMSO, ethanol, acetone, chloroform. |
| Appearance | White Crystalline Powder |
Shipping and Storage
| Store Temp | Ambient |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Stenfeldt AL, Karlsson J, Wennerås C, et al. Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor. Inflammation. 2007 Dec;30(6):224-9. PMID: 17687636.
Yan P, Nanamori M, Sun M, et al. The immunosuppressant cyclosporin A antagonizes human formyl peptide receptor through inhibition of cognate ligand binding. J Immunol. 2006 Nov 15;177(10):7050-8. PMID: 17082621.
de Paulis A, Ciccarelli A, de Crescenzo G, et al. Cyclosporin H is a potent and selective competitive antagonist of human basophil activation by N-formyl-methionyl-leucyl-phenylalanine. J Allergy Clin Immunol. 1996 Jul;98(1):152-64. PMID: 8765829.