Description
CZC-54252 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2) that exhibits neuroprotective activity. This compound may decrease neuronal injury in models of neurodegenerative diseases such as Parkinson’s disease.
Product Unit Size | Cost | Quantity | Stock |
---|
CZC-54252 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2) that exhibits neuroprotective activity. This compound may decrease neuronal injury in models of neurodegenerative diseases such as Parkinson’s disease.
Cas No. | 1191911-27-9 |
---|---|
Purity | ≥98% |
Formula | C22H25ClN6O4S |
Formula Wt. | 504.99 |
Chemical Name | N-{2-[(5-chloro-2-{[2-methoxy-4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}methanesulfonamide |
IUPAC Name | N-{2-[(5-Chloro-2-{[2-methoxy-4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)amino]phenyl}methanesulfonamide |
Synonym | SCHEMBL1460537; CHEBI:78414; BCP15148 |
Solubility | 100mM in DMSO |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet | |
Brochures |
Kramer T, Lo Monte F, Göring S, et al. Small molecule kinase inhibitors for LRRK2 and their application to Parkinson's disease models. ACS Chem Neurosci. 2012 Mar 21;3(3):151-60. PMID: 22860184.
Ramsden N, Perrin J, Ren Z, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8. PMID: 21812418.
Endogenous sphingolipid involved in cell signal...
Analog of staurosporine.
Triterpene saponin found in Bupleurum.
Cholesterol ester transfer protein inhibitor.
Endogenous amino acid, also found in meat, dair...
Mixture found in Croton, used to induce inflamm...
Serine protease substrate/inhibitor.
CB1 inverse agonist.
Docetaxel impurity
Cyclic hexapeptide isolated from Phomopsis lept...
Mineralocorticoid antagonist.
β2-adrenergic agonist.
Alkaloid found in marine sponges; vacuolar ATPa...
ALK inhibitor.
Nitrogen mustard, DNA alkylator.
α4β2 nAChR desensitizer, delayed-rectifier vo...
Phytoestrogen, isoflavone found in various plan...
Peptide, derivative of AT I, cleavage product o...
BHA derivative.
Antimicrobial peptide, generated during fibrin ...