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Daptomycin

Daptomycin

Product ID D0363
Cas No. 103060-53-3
Purity ≥97%
Product Unit SizeCostQuantityStock
5 mg $47.30 In stock
25 mg $126.00 In stock
100 mg $312.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Daptomycin is an anionic lipopeptide antibiotic that exhibits antibacterial efficacy and is used clinically to treat gram positive bacterial infections such as MRSA. Daptomycin induces reorganization of cell membranes and alters localization of proteins involved in cell division and cell wall synthesis; this compound also induces release of intracellular Ca2+ and other ions. This compound is also produced by the soil saprotroph Streptomyces roseosporus.

Product Info

Cas No.

103060-53-3

Purity

≥97%

Formula

C72H101N17O26

Formula Wt.

1620.67

Chemical Name

N-decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo -3-methyl-L-glutamyl-3-anthraniloyl-L-alanine[egr]1-lactone

IUPAC Name

(3S)-3-[[(2S)-4-amino-2-[[(2S)-2-(decanoylamino)-3-(1H-indol-3-yl)propanoyl]amino]-4-oxobutanoyl]amino]-4-[[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonazacyclohentriacont-30-yl]amino]-4-oxobutanoic acid

Solubility

Soluble in ethanol (50 mM), methano, DMF, DMSO (100 mM). Slightly soluble in water (25 mg/mL, 5 mM).

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

D0363 MSDS PDF

Info Sheet

D0363 Info Sheet PDF

References

Pogliano J, Pogliano N, Silverman JA. Daptomycin-mediated reorganization of membrane architecture causes mislocalization of essential cell division proteins. J Bacteriol. 2012 Sep;194(17):4494-504. PMID: 22661688.

Vilhena C, Bettencourt A. Daptomycin: a review of properties, clinical use, drug delivery and resistance. Mini Rev Med Chem. 2012 Mar;12(3):202-9. PMID: 22356191

Beiras-Fernandez A, Vogt F, Sodian R, et al. Daptomycin: a novel lipopeptide antibiotic against Gram-positive pathogens. Infect Drug Resist. 2010;3:95-101. PMID: 21694898.

Custom Order

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