• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Deferasirox

Deferasirox

Product ID D1621
Cas No. 201530-41-8
Purity ≥99%
Product Unit SizeCostQuantityStock
25 mg $101.00 In stock
100 mg $370.90 In stock
250 mg $718.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Deferasirox is an iron chelator commonly used to treat iron-overload disease. Deferasirox also displays both neuroprotective and chemotherapeutic benefit as well. This compound exhibits neuroprotective activity in both in vitro and in vivo models of stroke/ischemia conditions. In vitro, deferasirox increases expression of metastasis suppressing genes, p21, caspase-3, and PARP and decreases levels of cyclin D1 and activity of NF-κB. The ability of deferasirox to inhibit iron uptake decreases tumor growth in animal models of cancer.

Product Info

Cas No.

201530-41-8

Purity

≥99%

Formula

C21H15N3O4

Formula Wt.

373.63

Chemical Name

4-[3,5-Bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]- benzoic Acid

IUPAC Name

4-[(3Z,5E)-3,5-bis(6-oxocyclohexa-2,4-dien-1-ylidene)-1,2, 4-triazolidin-1-yl]benzoic acid

Synonym

ICL670A, CGP 72 670

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D1621 MSDS PDF

Info Sheet

D1621 Info Sheet PDF

References

Vazana-Barad L, Granot G, Mor-Tzuntz R, et al. Mechanism of the antitumoral activity of deferasirox, an iron chelation agent, on mantle cell lymphoma. Leuk Lymphoma. 2013 Apr;54(4):851-9. PMID: 23020673.

Lui GY, Obeidy P, Ford SJ, et al. The iron chelator, deferasirox, as a novel strategy for cancer treatment: oral activity against human lung tumor xenografts and molecular mechanism of action. Mol Pharmacol. 2013 Jan;83(1):179-90. PMID: 23074173.

Zhao Y, Rempe DA. Prophylactic neuroprotection against stroke: low-dose, prolonged treatment with deferoxamine or deferasirox establishes prolonged neuroprotection independent of HIF-1 function. J Cereb Blood Flow Metab. 2011 Jun;31(6):1412-23. PMID: 21245873.

Messa E, Carturan S, Maffè C, et al. Deferasirox is a powerful NF-kappaB inhibitor in myelodysplastic cells and in leukemia cell lines acting independently from cell iron deprivation by chelation and reactive oxygen species scavenging. Haematologica. 2010 Aug;95(8):1308-16. PMID: 20534700.

Lindsey WT, Olin BR. Deferasirox for transfusion-related iron overload: a clinical review. Clin Ther. 2007 Oct;29(10):2154-66. PMID: 18042472.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • D5709

    Docetaxel

    Semi-synthetic analog of taxol; microtubule dep...

    ≥98%
  • F3205

    Fibrinogen γ-chain Dodecapeptide

    Platelet substitute, peptide; GP IIb/IIIa activ...

    ≥95%
  • C2818

    Chelerythrine Chloride

    benzophenanthridine alkaloid found in Chelidoni...

    ≥98%
  • G0144

    Galactosamine Hydrochloride

    Galactose-derived hexosamine sugar, component o...

    ≥98%
  • B3358

    Biochanin A

    Phytoestrogen, flavonoid found in clover, soy, ...

    ≥98%
  • G1652

    Genistein

    Phytoestrogen, isoflavone found in various plan...

    ≥98%
  • B6856

    5-Bromo-2′-Deoxyuridine

    Nucleoside (thymidine) analog.

    ≥98%
  • E6825

    Ergosterol

    Sterol cell membrane component found in yeast a...

    ≥96%
  • P1770

    Perillyl Alcohol

    Terpene found in various plant and fruit source...

    ≥85%
  • G124090

    GDC-6036

    KRAS inhibitor

    ≥98%
  • A0819

    Acetylsalicylic Acid

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • B3458

    Biopterin

    Endogenous pterin coenzyme required for release...

    ≥98%
  • P7056

    Procaterol Hydrochloride

    β2-adrenergic agonist.

    ≥98%
  • H0207

    Hepatitis B Virus Core Protein (128-140)

    B cell epitope found on hepatitis B viral core ...

    ≥95%
  • B3320

    Bifonazole

    Imidazole; HMG-CoA reductase, 14-α demethylase...

    ≥98%
  • C9863

    Cyproconazole

    Triazole; 14-α demethylase inhibitor, voltage-...

    ≥95%
  • T1006

    10-Acetoacetyl Paclitaxel

    Synthesis impurity

    ≥95%
  • Z0252

    Zanamivir

    Neuraminidase inhibitor.

    ≥98%
  • C0255

    Cantharidin

    Toxin produced by Canarthis vesicatoria; PP1/2A...

    ≥98%
  • S2957

    Shogaol

    Phenol found in Zingiber; PPARγ agonist, 5-HT3...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only