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Dehydroepiandrosterone

Dehydroepiandrosterone

Product ID D1629
Cas No. 53-43-0
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $84.00 In stock
25 g $336.00 In stock
100 g $918.80 In stock
Bulk Quote

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  • Product Info
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  • Description
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Description

Dehydroepiandrosterone (DHEA) is an endogenous steroid hormone produced in the adrenal glands, gonads, and brain; it is an intermediate in the synthesis of estrogens and androgens. DHEA exhibits neuroprotective, cognition enhancing, anti-androgenic, anticancer, anti-metastatic, antiepileptic/anticonvulsant, anti-asthma, antacid, and anti-ulcerative activities. DHEA enhances working memory and cognition in clinical settings. DHEA acts as a partial agonist at androgen receptors and ERα receptors, as a full agonist at ERβ receptors, NMDA receptors, and σ1 receptors, and an antagonist at GABA-A receptors. Additionally, DHEA binds PPARα, pregnane X receptors (PXRs), and CXRs. In cellular models of cervical cancer, DHEA inhibits cell proliferation, migration, and adhesion. This compound’s antiepileptic activity potentially occurs through increasing expression of various glutamate transporters. In bronchial epithelial cells, DHEA inhibits the epithelial-to-mesenchymal transition (EMT), decreases levels of α-SMA, and increases levels 0f E-cadherin; it also displays bronchodilatory benefit in vivo. In other animal models, this compound decreases gastric acid secretion, lipid peroxidation, and ulcer formation.

 

Product Info

Cas No.

53-43-0

Purity

≥98%

Formula

C19H28O2

Formula Wt.

288.42

Chemical Name

(3β)-3-Hydroxyandrost-5-en-17-one

IUPAC Name

(3S,8R,9S,10R,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14, 15,16-dodecahydrocyclopenta[a]phenanthren-17-one

Synonym

Prasterone, DHEA, Dehydroepiandosterone

Melting Point

149-151°C

Solubility

Soluble in ethanol or DMSO. Insoluble in water.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D1629 MSDS PDF

Info Sheet

D1629 Info Sheet PDF

References

do Vale S, Selinger L, Martins JM, et al. The relationship between dehydroepiandrosterone (DHEA), working memory and distraction--a behavioral and electrophysiological approach. PLoS One. 2014 Aug 8;9(8):e104869. PMID: 25105970.

Ortega-Calderón YN, López-Marure R. Dehydroepiandrosterone inhibits proliferation and suppresses migration of human cervical cancer cell lines. Anticancer Res. 2014 Aug;34(8):4039-44. PMID: 25075027.

Xu L, Xiang X, Ji X, et al. Effects and mechanism of dehydroepiandrosterone on epithelial-mesenchymal transition in bronchial epithelial cells. Exp Lung Res. 2014 Jun;40(5):211-21. PMID: 24784499.

Eleawa S, Bin-Jaliah I, Alkhateeb M, et al. The impact of dehydroepiandrosterone on indomethacin-induced gastric lesions in rats. Acta Physiol Hung. 2014 Mar;101(1):77-87. PMID: 24631796.

Engdahl C, Lagerquist MK, Stubelius A, et al. Role of androgen and estrogen receptors for the action of dehydroepiandrosterone (DHEA). Endocrinology. 2014 Mar;155(3):889-96. PMID: 24424045.

Neunzig J, Bernhardt R. Dehydroepiandrosterone sulfate (DHEAS) stimulates the first step in the biosynthesis of steroid hormones. PLoS One. 2014 Feb 21;9(2):e89727. PMID: 24586990.

Espinoza J, Montaño LM, Perusquía M. Nongenomic bronchodilating action elicited by dehydroepiandrosterone (DHEA) in a guinea pig asthma model. J Steroid Biochem Mol Biol. 2013 Nov;138:174-82. PMID: 23727130.

Mishra M, Singh R, Mukherjee S, et al. Dehydroepiandrosterone's antiepileptic action in FeCl3-induced epileptogenesis involves upregulation of glutamate transporters. Epilepsy Res. 2013 Sep;106(1-2):83-91. PMID: 23891458.

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