• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Diacetoxyscirpenol

Diacetoxyscirpenol

Product ID D3200
Cas No. 2270-40-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $80.10 In stock
5 mg $337.30 In stock
10 mg $590.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Diacetoxyscirpenol (DAS) is a type A trichothecene mycotoxin initially produced by species of Fusarium. DAS primarily exhibits immunosuppressive and, potentially, anticancer activities; it is cytotoxic to most cell types and tissues in vivo. In Jurkat T cells, DAS initiates activation of caspases 3, 8, and 9, degradation of poly(ADP)-ribosomal polymerase (PARP), release of mitochondrial cytochrome c, as well as downregulation of Bcl-2, cdk4, and cyclin B1; together, this results in apoptosis and cell death. In other cellular models, DAS inhibits the killing action of phagocytic cells such as macrophages, decreasing generation of superoxide anions and altering lysozyme capabilities.

Product Info

Cas No.

2270-40-8

Purity

≥98%

Formula

C19H26O7

Formula Wt.

366.41

Chemical Name

[(1S,2R,7R,9R,10R,11S,12S)-11-acetyloxy-10-hydroxy-1,5-dimethylspiro[8-oxatricyclo[7.2.1.02,7]dodec-5-ene-12,2'-oxirane]-2-yl]methyl acetate

IUPAC Name

[(1S,2R,7R,9R,10R,11S,12S)-11-acetyloxy-10-hydroxy-1,5-dimethylspiro[8-oxatricyclo[7.2.1.02,7]dodec-5-ene-12,2'-oxirane]-2-yl]methyl acetate

Synonym

Anguidin, Anguidine

Melting Point

160-164°C

Solubility

Insoluble in water. Soluble in methanol (10 mg/mL), and acetone.

Appearance

White powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

D3200 MSDS PDF

Info Sheet

D3200 Info Sheet PDF

References

Jun DY, Kim JS, Park HS, et al. Cytotoxicity of diacetoxyscirpenol is associated with apoptosis by activation of caspase-8 and interruption of cell cycle progression by down-regulation of cdk4 and cyclin B1 in human Jurkat T cells. Toxicol Appl Pharmacol. 2007 Jul 15;222(2):190-201. PMID: 17559898.

Nasri T, Bosch RR, Voorde St, et al. Differential induction of apoptosis by type A and B trichothecenes in Jurkat T-lymphocytes. Toxicol In Vitro. 2006 Sep;20(6):832-40. PMID: 16472964.

Ayral AM, Dubech N, Le Bars J, et al. In vitro effect of diacetoxyscirpenol and deoxynivalenol on microbicidal activity of murine peritoneal macrophages. Mycopathologia. 1992 Nov;120(2):121-7. PMID: 1336129.

Coppock RW, Gelberg HB, Hoffmann WE, et al. The acute toxicopathy of intravenous diacetoxyscirpenol (anguidine) administration in swine. Fundam Appl Toxicol. 1985 Dec;5(6 Pt 1):1034-49. PMID: 4092867.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • S0253

    Sanguinarine

    Benzophenanthridine alkaloid found in various p...

    ≥98%
  • T1605

    Tebuconazole

    Triazole; 14-α demethylase inhibitor, voltage-...

    ≥98%
  • C1613

    Cediranib

    VEGFR inhibitor.

    ≥98%
  • D5692

    Doxifluridine

    5-Fluorouracil prodrug, pyrimidine nucleoside a...

    ≥98%
  • B1652

    Benzo[a]pyrene

    Polycyclic aromatic hydrocarbon (PAH) found in ...

    ≥98%
  • P5747

    Polymyxin B sulfate

    Cationic lipid polypeptide, mixture of polymyxi...

    ≥6500 iu/mg
  • A7577

    Astilbin

    Flavonoid found in various plant sources.

    ≥99%
  • G5216

    GNE-7915

    LRRK2 inhibitor.

    ≥98%
  • A4802

    Amantadine Hydrochloride

    Viral M2 proton channel blocker, MAO-A, NET, NM...

    ≥98%
  • C0250

    Calcitonin Gene Related Peptide II, human

    Calcitonin-family peptide, involved in vasodila...

    ≥95%
  • D0261

    Dapivirine

    RT inhibitor.

    ≥98%
  • N1980

    Neuromedin B, pig

    Endogenous bombesin-related peptide, involved i...

    ≥95%
  • R3477

    Ritodrine Hydrochloride

    Phenylethylamine; β2-adrenergic agonist, SK/BK...

    ≥98%
  • B3573

    Bisdemethoxycurcumin

    Curcumin derivative; DNMT1 and α-amylase inhib...

    ≥98%
  • G4596

    Glycidamide

    Epoxide metabolite of acrylamide, induces DNA a...

    ≥98%
  • M185777

    4-(Methylsulfinyl) butylamine

    ≥99%
  • A8644

    AVL-292

    BTK inhibitor.

    ≥98%
  • J0240

    JAK2 Inhibitor V

    JAK2 inhibitor.

    ≥98%
  • A5378

    Antimycin A

    Oxidative phosphorylation inhibitor.

  • E6134

    Epimedin C

    Flavonoid found in Epimedium sagittatum.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only