• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Diosgenin

Diosgenin

Product ID D3355
Cas No. 512-04-9
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $60.10 In stock
100 g $240.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Diosgenin is a steroidal saponin found in Dioscorea that exhibits anticancer, anti-inflammatory, neuroprotective, cognition enhancing, and anti-hyperlipidemic activities. In breast cancer cells, diosgenin inhibits cell migration, actin polymerization, Vav2 phosphorylation, and Cdc42 activation. In macrophages, diosgenin inhibits production of NO and ROS, expression of iNOS, IL-6, and IL-1β, and activation of JNK. Additionally, diosgenin improves performance on object recognition memory tasks and decreases amyloid-β (Aβ) plaque formation in the cortex and hippocampus of animal models of Alzheimer’s disease. In diabetic mice, this compound decreases levels of triglycerides and inhibits activation of LXRα, ameliorating dyslipidemia.

Product Info

Cas No.

512-04-9

Purity

≥98%

Formula

C27H42O3

Formula Wt.

414.62

IUPAC Name

(1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R,16S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-ol

Synonym

(25R)-5-Spirosten-3beta-ol, 3beta-Hydroxy-5-spirostene

Melting Point

195-204°C

Solubility

Soluble in CHCl3 (20mg/mL).

Appearance

White or Almost-White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D3355 MSDS PDF

Info Sheet

D3355 Info Sheet PDF

References

He Z, Chen H, Li G, et al. Diosgenin inhibits the migration of human breast cancer MDA-MB-231 cells by suppressing Vav2 activity. Phytomedicine. 2014 Mar 18. [Epub ahead of print]. PMID: 24656238.

Tohda C, Urano T, Umezaki M, et al. Diosgenin is an exogenous activator of 1,25D3-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice. Sci Rep. 2012;2:535. PMID: 22837815.

Uemura T, Goto T, Kang MS, et al. Diosgenin, the main aglycon of fenugreek, inhibits LXRα activity in HepG2 cells and decreases plasma and hepatic triglycerides in obese diabetic mice. J Nutr. 2011 Jan;141(1):17-23. PMID: 21106928.

Jung DH, Park HJ, Byun HE, et al. Diosgenin inhibits macrophage-derived inflammatory mediators through downregulation of CK2, JNK, NF-kappaB and AP-1 activation. Int Immunopharmacol. 2010 Sep;10(9):1047-54. PMID: 20601188.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • H9863

    Hyperforin Dicyclohexylammonium

    Stable salt form of hyperforin, a compound foun...

    ≥97%
  • C9876

    CYT-387

    JAK2 inhibitor.

    ≥98%
  • M3196

    MHY-1485

    mTOR activator.

    ≥98%
  • R2788

    RGW-611

    Morpholine derivative.

    ≥98%
  • E544766

    Enterocin

    A bacteriocin

    ≥95%
  • E5578

    Entecavir Hydrate

    Nucleoside (deoxyguanosine) analog; DNA chain t...

    ≥99%
  • A5170

    Amrinone

    Pyridine; PDE3 inhibitor.

    ≥98%
  • S7870

    Streptozocin

    Nitrosourea-amino sugar conjugate, DNA cross-li...

    ≥98%
  • T286165

    Theaflavin-3-gallate

    Polyphenolic compound present in black tea.

    ≥95%
  • R1806

    Rebamipide

    Quinolone, antioxidant.

    ≥98%
  • M1877

    Methylprednisolone

    Synthetic steroid; glucocorticoid agonist.

    ≥96%
  • Z160021

    Zearalanone

    Mycotoxin.

    ≥97%
  • P6857

    Protocatechuic Acid

    Polyphenol found in many plants and foods.

    ≥97%
  • M400220

    MK-2206 Dihydrochloride

    Akt inhibitor.

    ≥99%
  • C0377

    Catharanthine Sulfate

    Alkaloid found in Catharanthus, precursor in sy...

    ≥98%
  • D3351

    4-Dimethylaminopyridine

    Acyl transfer catalyst, involved in peptide syn...

    ≥98%
  • N8561

    NVP-AEW541

    IGF-1R inhibitor.

    ≥98%
  • N859610

    NVP-HDM201

    HDM2 inhibitor

    ≥99%
  • C4417

    Clemizole

    TRPC5 activator, NS4B and histamine H1 inhibito...

    ≥98%
  • B3272

    Bis(3,5-dibromosalicyl) Fumarate

    Aspirin analog; hemoglobin chain cross-linker.<...

    ≥91%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only