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Thioctic/lipoic acid is an endogenous organosulfur that exhibits antioxidative activity. This compound is commercially used as a dietary supplement and can be found in meat and leafy vegetables. Thioctic/lipoic acid is required for aerobic metabolism and functions as a cofactor for the pyruvate dehydrogenase complex. In vitro, this compound increases activation of phase II enzymes and scavenges ROS and RNS, protecting against oxidative stress.
| Cas No. | 1077-28-7 |
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| Purity | ≥99% |
| Formula | C8H14O2S2 |
| Formula Wt. | 206.33 |
| Chemical Name | 1,2-Dithiolane-3-pentanoic acid |
| IUPAC Name | 5-(dithiolan-3-yl)pentanoic acid |
| Synonym | D,L-Thioctic acid |
| Melting Point | 60-62°C |
| Solubility | Insoluble in water. Soluble in fat solvents. |
| Appearance | Yellow crystal powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Shay KP, Moreau RF, Smith EJ, et al. Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta. 2009 Oct;1790(10):1149-60. PMID: 19664690.
Petersen Shay K, Moreau RF, et al. Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity. IUBMB Life. 2008 Jun;60(6):362-7. PMID: 18409172.