• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Donepezil Hydrochloride

Donepezil Hydrochloride

Product ID D5753
Cas No. 120011-70-3
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $89.70 In stock
100 mg $280.60 In stock
500 mg $1,010.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Donepezil is an acetylcholinesterase (AChE) inhibitor that is clinically used to treat Alzheimer’s disease. Donepezil displays neuroprotective, cognition enhancing, cardioprotective, and anti-inflammatory activities. In animal models, donepezil improves memory and learning ability. In vitro, donepezil downregulates expression of the NR1 subunit of NMDA receptors, inhibiting glutamate-mediated Ca2+ entry into cells; this mechanism is thought to be dependent on donepezil activity on α7 nicotinic acetylcholine receptors (nAChRs). Additionally, this compound inhibits glycogen synthase kinase 3 (GSK3) and activates PI3K/Akt signaling, helping to prevent amyloid-β (Aβ) toxicity. Donepezil also binds to σ1 receptors. In animal models of congestive heart failure, donepezil decreases left ventricular end diastolic pressure, increases left ventricular contractility, decreases left ventricular expression of brain natriuretic peptide (BNP), and decreases heart weight, resulting in greater survival rates.

Product Info

Cas No.

120011-70-3

Purity

≥98%

Formula

C24H29NO3 • HCl

Formula Wt.

415.95

Chemical Name

2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrochloride

IUPAC Name

2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2, 3-dihydroinden-1-one;hydrochloride

Synonym

Aricept, BNAG

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D5753 MSDS PDF

Info Sheet

D5753 Info Sheet PDF

References

Jiang Y, Zou Y, Chen S, et al. The anti-inflammatory effect of donepezil on experimental autoimmune encephalomyelitis in C57 BL/6 mice. Neuropharmacology. 2013 Oct;73:415-24. PMID: 23831366.

Xia Z, Zhang R, Wu P, et al. Memory defect induced by β-amyloid plus glutamate receptor agonist is alleviated by catalpol and donepezil through different mechanisms. Brain Res. 2012 Mar 2;1441:27-37. PMID: 22305339.

Shen H, Kihara T, Hongo H, et al. Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of alpha7 nicotinic receptors and internalization of NMDA receptors. Br J Pharmacol. 2010 Sep;161(1):127-39. Erratum in: Br J Pharmacol. 2010 Nov;161(5):1200. PMID: 20718745.

Handa T, Katare RG, Kakinuma Y, et al. Anti-Alzheimer's drug, donepezil, markedly improves long-term survival after chronic heart failure in mice. J Card Fail. 2009 Nov;15(9):805-11. PMID: 19879468.

Ishikawa M, Sakata M, Ishii K, et al. High occupancy of sigma1 receptors in the human brain after single oral administration of donepezil: a positron emission tomography study using [11C]SA4503. Int J Neuropsychopharmacol. 2009 Sep;12(8):1127-31. PMID: 19573265.

Noh MY, Koh SH, Kim Y, et al. Neuroprotective effects of donepezil through inhibition of GSK-3 activity in amyloid-beta-induced neuronal cell death. J Neurochem. 2009 Mar;108(5):1116-25. PMID: 19077054.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • P1917

    Phenylethyl 3-methylcaffeate

    Derivative of methyl caffeate, hydroxycinnamic ...

    ≥97%
  • D1695

    Dexamethasone Phosphate Sodium

    Steroid; glucocorticoid agonist.

    ≥98%
  • W7200

    WS3

    Islet β cell proliferation stimulator.

    ≥98%
  • C4557

    Clofibrate

    Fibrate; PPARα agonist.

    ≥99%
  • A4578

    Altretamine

    DNA alkylator.  
    ≥98%
  • A5314

    Dehydroandrographolide

    Labdane diterpene found in Andrographis.

    ≥98%
  • G7862

    GTPL-5846

    GPR84 agonist.

    ≥98%
  • R9632

    Recombinant Zika Virus NS1 Antigen

    Zika Virus antigen

  • S1604

    Secretin Acetate

    Endogenous peptide hormone, involved in feeding...

    ≥95%
  • T1016

    Propyl Analog of Paclitaxel

    Fermentation impurity

    ≥95%
  • M324083

    Micafungin

    Echinocandin

    ≥95%
  • A7578

    Astragaloside IV

    Found in Astragalus membranaceus.

    ≥98%
  • G6802

    Granisetron Hydrochloride

    5-HT3 antagonist.

    ≥98%
  • T2668

    TGR5 Receptor Agonist

    TGR5 agonist.

    ≥99%
  • A2056

    Aflatoxin Q1

    Mycotoxin metabolite

    ≥98%
  • D0011

    Dacarbazine

    DNA alkylator.

    ≥98%
  • N5766

    L-(-)-Norepinephrine Bitartrate Monohydrate

    Endogenous hormone and neurotransmitter involve...

    ≥98%
  • R3321

    Rifaximin

    Rifampicin derivative; DNA-dependent RNA polyme...

    ≥98%
  • K0030

    Kahweol

    Diterpene found in coffee beans.

    ≥97%
  • C3374

    Cisplatin

    Pt-based DNA cross-linker.

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only