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Donepezil Hydrochloride

Donepezil Hydrochloride

Product ID D5753
Cas No. 120011-70-3
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $89.70 In stock
100 mg $280.60 In stock
500 mg $1,010.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Donepezil is an acetylcholinesterase (AChE) inhibitor that is clinically used to treat Alzheimer’s disease. Donepezil displays neuroprotective, cognition enhancing, cardioprotective, and anti-inflammatory activities. In animal models, donepezil improves memory and learning ability. In vitro, donepezil downregulates expression of the NR1 subunit of NMDA receptors, inhibiting glutamate-mediated Ca2+ entry into cells; this mechanism is thought to be dependent on donepezil activity on α7 nicotinic acetylcholine receptors (nAChRs). Additionally, this compound inhibits glycogen synthase kinase 3 (GSK3) and activates PI3K/Akt signaling, helping to prevent amyloid-β (Aβ) toxicity. Donepezil also binds to σ1 receptors. In animal models of congestive heart failure, donepezil decreases left ventricular end diastolic pressure, increases left ventricular contractility, decreases left ventricular expression of brain natriuretic peptide (BNP), and decreases heart weight, resulting in greater survival rates.

Product Info

Cas No.

120011-70-3

Purity

≥98%

Formula

C24H29NO3 • HCl

Formula Wt.

415.95

Chemical Name

2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrochloride

IUPAC Name

2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2, 3-dihydroinden-1-one;hydrochloride

Synonym

Aricept, BNAG

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D5753 MSDS PDF

Info Sheet

D5753 Info Sheet PDF

References

Jiang Y, Zou Y, Chen S, et al. The anti-inflammatory effect of donepezil on experimental autoimmune encephalomyelitis in C57 BL/6 mice. Neuropharmacology. 2013 Oct;73:415-24. PMID: 23831366.

Xia Z, Zhang R, Wu P, et al. Memory defect induced by β-amyloid plus glutamate receptor agonist is alleviated by catalpol and donepezil through different mechanisms. Brain Res. 2012 Mar 2;1441:27-37. PMID: 22305339.

Shen H, Kihara T, Hongo H, et al. Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of alpha7 nicotinic receptors and internalization of NMDA receptors. Br J Pharmacol. 2010 Sep;161(1):127-39. Erratum in: Br J Pharmacol. 2010 Nov;161(5):1200. PMID: 20718745.

Handa T, Katare RG, Kakinuma Y, et al. Anti-Alzheimer's drug, donepezil, markedly improves long-term survival after chronic heart failure in mice. J Card Fail. 2009 Nov;15(9):805-11. PMID: 19879468.

Ishikawa M, Sakata M, Ishii K, et al. High occupancy of sigma1 receptors in the human brain after single oral administration of donepezil: a positron emission tomography study using [11C]SA4503. Int J Neuropsychopharmacol. 2009 Sep;12(8):1127-31. PMID: 19573265.

Noh MY, Koh SH, Kim Y, et al. Neuroprotective effects of donepezil through inhibition of GSK-3 activity in amyloid-beta-induced neuronal cell death. J Neurochem. 2009 Mar;108(5):1116-25. PMID: 19077054.

Custom Order

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