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Dopamine is an endogenous hormone neurotransmitter that binds and activates dopamine receptors. Dopamine binding to D1/2/5 receptors increases levels of cAMP and dopamine binding to D3/4 receptors decreases levels of cAMP. Dopamine plays a role in motor control, mood, cognition, reward signaling, nausea, and arousal. Dopamine also exhibits immunomodulatory activity, activating naïve and resting T cells and inhibiting activated T cells.
| Cas No. | 62-31-7 |
|---|---|
| Purity | ≥99% |
| Formula | C8H11NO2 • HCl |
| Formula Wt. | 189.64 |
| Chemical Name | 4-(2-Aminoethyl)-1,2-benzenediol hydrochloride |
| IUPAC Name | 4-(2-aminoethyl)benzene-1,2-diol;hydrochloride |
| Synonym | Cariosteril, Dopastat, Dynatra, Inovan, Inotropin, 3-hydroxytyramine hydrochloride |
| Melting Point | 241°C (dec) |
| Solubility | Soluble in water (100 mM), methanol and hot ethanol (20 mg/mL). DMSO to 38 mg/mL. Practically insoluble in ether, chloroform, benzene and toluene. |
| Appearance | White to off white powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Cachope R, Cheer JF. Local control of striatal dopamine release. Front Behav Neurosci. 2014 May 23;8:188. PMID: 24904339.
Pacheco R, Contreras F, Zouali M. The dopaminergic system in autoimmune diseases. Front Immunol. 2014 Mar 21;5:117. PMID: 24711809.
Blier P. Neurotransmitter targeting in the treatment of depression. J Clin Psychiatry. 2013;74 Suppl 2:19-24. PMID: 24191974.
Sarkar C, Basu B, Chakroborty D, et al. The immunoregulatory role of dopamine: an update. Brain Behav Immun. 2010 May;24(4):525-8. dPMID: 19896530.