• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Duloxetine Hydrochloride

Duloxetine Hydrochloride

Product ID D8145
Cas No. 136434-34-9
Purity ≥99%
Product Unit SizeCostQuantityStock
100 mg $92.00 In stock
250 mg $173.70 In stock
1 g $408.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Duloxetine hydrochloride is a competitive inhibitor of serotonin and norepinephrine transporters (SERT, NET) that is clinically used to treat depression, anxiety, neuropathy, fibromyalgia, and stress urinary incontinence. Duloxetine’s inhibition of neurotransmitter reuptake alters downstream signaling mediated by NMDA receptors and NO as well. The inhibitory activity of this compound on neurotransmitter reuptake is related to its antidepressant and anxiolytic characteristics. The effects of duloxetine as a treatment for neuropathy and fibromyalgia, however, are likely due to its antagonist activity at voltage-gated Nav1.7 Na+ channels, which are involved in fibromyalgia and pain signaling.

Product Info

Cas No.

136434-34-9

Purity

≥99%

Formula

C18H19NOS • HCl

Formula Wt.

333.88

Chemical Name

(+)-(S)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine hydrochloride

IUPAC Name

(3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine; hydrochloride

Synonym

LY-248686 hydrochloride, Cymbalta, Ariclaim

Solubility

Soluble in water (5 mg/ml), methanol, DMSO (67 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C)

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D8145 MSDS PDF

Info Sheet

D8145 Info Sheet PDF

References

Wang SY, Calderon J, Kuo Wang G. Block of neuronal Na+ channels by antidepressant duloxetine in a state-dependent manner. Anesthesiology. 2010 Sep;113(3):655-65. PMID: 20693878.

Carter NJ, McCormack PL. Duloxetine: a review of its use in the treatment of generalized anxiety disorder. CNS Drugs. 2009;23(6):523-41. PMID: 19480470.

Apparsundaram S, Stockdale DJ, Henningsen RA, et al. Antidepressants targeting the serotonin reuptake transporter act via a competitive mechanism. J Pharmacol Exp Ther. 2008 Dec;327(3):982-90. PMID: 18801947.

Müller N, Schennach R, Riedel M, et al. Duloxetine in the treatment of major psychiatric and neuropathic disorders. Expert Rev Neurother. 2008 Apr;8(4):527-36. PMID: 18416656.

Sweeney DD, Chancellor MB. Treatment of stress urinary incontinence with duloxetine hydrochloride. Rev Urol. 2005 Spring;7(2):81-6. PMID: 16985814.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • F8147

    Fulvestrant

    Induces ER degradation.

    ≥98%
  • B5609

    Boc-GRR-AMC

    Peptide, protease substrate.

    ≥98%
  • F4483

    Flufenamic Acid

    NSAID; TREK1 K+ potentiator, voltage-gated Na+ ...

    ≥97%
  • I7459

    1-Isothiocyanato-8-(methylsulfinyl)-octane

    ITC found in Nasturtium officinale (watercress)...

    ≥98%
  • T0108

    10-Deacetyl-7-xylosyltaxol

    Taxane found in species of Taxus; potential mic...

    ≥98%
  • R5773

    Rosiglitazone

    Thiazolidinedione; PPARγ agonist.

    ≥99%
  • I7259

    Isoproterenol Hydrochloride

    β-adrenergic agonist.

    ≥98%
  • G0104

    Gabexate Mesylate

    Proteasome inhibitor.

    ≥99%
  • B6816

    Brefeldin A

    Lactone found in fungi such as Eupenicillium; g...

    ≥97%
  • J291331

    JH-II-127

    Selective inhibitor of LRRK2.

    ≥98%
  • S1846

    Selumetinib

    MEK1/2 inhibitor.

    ≥99%
  • D3429

    Dihydrocytochalasin B

    Mycotoxin derivative; actin polymerization inhi...

    ≥98%
  • A4523

    Alfuzosin Hydrochloride

    α1-adrenergic antagonist.

    ≥97%
  • S680000

    SR144528

    Selective cannabinoid receptor 2 (CB2) inverse ...

    ≥98%
  • T982698

    L-Tyrosine disodium salt

    Amino acid precursor of dopamine.

    ≥98%
  • M0278

    Matrine

    Alkaloid found in Sophora.

    ≥98%
  • P0246

    Palomid 529

    mTOR inhibitor.

    ≥98%
  • T698579

    Tropodithietic Acid

    Produced by various marine proteobacteria

    ≥99%
  • P0369

    Parecoxib Sodium

    NSAID; COX-2 inhibitor.

    ≥99%
  • T0103

    Taxol Side Chain Diol

    Side chain attached to various taxanes.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only