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E-JIB-04

E-JIB-04

Product ID J3204
Cas No. 199596-05-9
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $118.00 In stock
25 mg $405.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

E-JIB-04 is the E stereoisomer of JIB-04, an inhibitor of Jumonji family histone demethylases; it does not inhibit activity of α-ketoglutarate. JIB-04 exhibits anticancer chemotherapeutic activity, inhibiting protein translation initiation. In cancer models, JIB-04 inhibits cell viability, decreases tumor burden, and increases survival rates.

Product Info

Cas No.

199596-05-9

Purity

≥98%

Formula

C17H13ClN4

Formula Wt.

308.77

Chemical Name

(E)-N-(5-Chloro-pyridin-2-yl)-N′-(phenyl-pyridin-2-yl-methylene)-hydrazine

IUPAC Name

5-Chloro-2-{(2E)-2-[phenyl(2-pyridinyl)methylene]hydrazino}pyridine

Synonym

NSC 693627, JHDM inhibitor VII

Solubility

DMSO 25 mg/mL Water Insoluble Ethanol Insoluble

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

J3204 MSDS PDF

Info Sheet

J3204 Info Sheet PDF

References

Van Rechem C, Black JC, Boukhali M, et al. Lysine demethylase KDM4A associates with translation machinery and regulates protein synthesis. Cancer Discov. 2015 Mar;5(3):255-63. PMID: 25564516.

Wang L, Chang J, Varghese D, et al. A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nat Commun. 2013;4:2035. Erratum in: Nat Commun. 2013;4:2639. PMID: 23792809.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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