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Efavirenz

Efavirenz

Product ID E2003
Cas No. 154598-52-4
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $68.30 In stock
10 mg $89.30 In stock
25 mg $152.30 In stock
50 mg $236.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that exhibits antiviral and anticancer activities. Efavirenz is clinically used to treat HIV infection; it induces autophagy in neurons, leading to some centrally mediated toxicity. In various cancer cell lines, efavirenz inhibits cellular proliferation and increases activation of p53.

Product Info

Cas No.

154598-52-4

Purity

≥99%

Formula

C14H9ClF3NO2

Formula Wt.

315.67

IUPAC Name

(4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one

Melting Point

139-141°C

Solubility

Ethanol (20 mg/ml), DMF (20 mg/ml), DMSO (14 mg/ml)

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

E2003 MSDS PDF

Info Sheet

E2003 Info Sheet PDF

Brochures

Antivirals Booklet

References

Schauer GD, Huber KD, Leuba SH, et al. Mechanism of allosteric inhibition of HIV-1 reverse transcriptase revealed by single-molecule and ensemble fluorescence. Nucleic Acids Res. 2015 Feb 1;42(18):11687-96. PMID: 25232099.

Purnell PR, Fox HS. Efavirenz induces neuronal autophagy and mitochondrial alterations. J Pharmacol Exp Ther. 2014 Nov;351(2):250-8. PMID: 25161171.

Hecht M, Harrer T, Büttner M, et al. Cytotoxic effect of efavirenz is selective against cancer cells and associated with the cannabinoid system. AIDS. 2013 Aug 24;27(13):2031-40. PMID: 23612009.

Custom Order

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