Enalaprilat Dihydrate

Name: Enalaprilat Dihydrate
SKU: E5200
Availability: InStock

Product ID E5200

Cas No. 84680-54-6

Purity ≥98%

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Description

Enalaprilat is the active metabolite of enalapril. Enalapril is an angiotensin-converting enzyme (ACE) inhibitor that is clinically used to treat hypertension, heart failure, and diabetic nephropathy. Enalapril exhibits antihypertensive activity. Enalapril prevents and reverses renovascular hypertension-induced smooth muscle hypertrophy, collagen deposition, carotid media thickness growth, and other parameters of arterial remodeling. Additionally, enalapril improves endothelial function in migraine sufferers by increasing levels of NO.

Product Info

Cas No.	84680-54-6
Purity	≥98%
Formula	C₁₈H₂₄N₂O₅ • 2H₂O
Formula Wt.	384.42
Chemical Name	N-[(1S)-Carboxy- 3-phenylpropyl]-L-alanyl-L-proline dihydrate
IUPAC Name	(2S)-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]propanoyl]pyrrolidine-2-carboxylic acid;dihydrate
Synonym	Enalaprilic acid, Vasotec IV
Melting Point	148-151°C
Solubility	Slightly soluble in water (14 mg/mL at 60 oC) DMSO (64 mg/mL), methanol (14 mg/mL).
Appearance	White or almost white crystalline powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	E5200 MSDS PDF
Info Sheet	E5200 Info Sheet PDF

References

Chen JL, Shang QH, Hu W, et al. Role of TGF-β1/Smads pathway in carotid artery remodeling in renovascular hypertensive rats and prevention by Enalapril and Amlodipine. J Geriatr Cardiol. 2012 Jun;9(2):185-91. PMID: 22916067.

Bilan VP, Salah EM, Bastacky S, et al. Diabetic nephropathy and long-term treatment effects of rosiglitazone and enalapril in obese ZSF1 rats. J Endocrinol. 2011 Sep;210(3):293-308. PMID: 21680617.

Javanmard SH, Sonbolestan SA, Heshmat-Ghahdarijani K, et al. Enalapril improves endothelial function in patients with migraine: A randomized, double-blind, placebo-controlled trial. J Res Med Sci. 2011 Jan;16(1):26-32. PMID: 21448379.

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Enalaprilat Dihydrate

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

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