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Endomorphin-1 is an endogenous agonist at μ-opioid receptors (μORs) in the spinal cord; it exhibits antinociceptive/analgesic, immunosuppressive, and pro-angiogenic activities. Endomorphin-1 increases pain thresholds in animal models of thermal pain and inhibits the formation of antibodies in other cellular models. In HUVECs, this peptide stimulates proliferation, migration, adhesion, and tube formation.
| Cas No. | 189388-22-5 |
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| Purity | ≥95% |
| Formula | C34H38N6O5 |
| Formula Wt. | 610.72 |
| IUPAC Name | (2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(2S)-1-[[(2S)-1- amino-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2- yl]pyrrolidine-2-carboxamide |
| Solubility | Soluble in water (0.6 mg/mL), DMSO. |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Dai X, Song HJ, Cui SG, et al. The stimulative effects of endogenous opioids on endothelial cell proliferation, migration and angiogenesis in vitro. Eur J Pharmacol. 2010 Feb 25;628(1-3):42-50. PMID: 19932695.
Anton B, Leff P, Calva JC, et al. Endomorphin 1 and endomorphin 2 suppress in vitro antibody formation at ultra-low concentrations: anti-peptide antibodies but not opioid antagonists block the activity. Brain Behav Immun. 2008 Aug;22(6):824-32. PMID: 18374539.