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Enoxacin

Enoxacin

Product ID E5358
Cas No. 74011-58-8
Purity ≥98%
Product Unit SizeCostQuantityStock
500 mg $55.50 In stock
1 g $92.30 In stock
5 g $294.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Enoxacin is a fluoroquinolone antibiotic that is clinically used to treat urinary tract infections and gonorrhea; like other fluoroquinolones, enoxacin inhibits DNA gyrase and topoisomerase IV. Enoxacin displays antibacterial and anti-resorptive activities. In vivo, this compound decreases RANKL-induced JNK signaling, inhibiting osteoclast formation. Additionally, enoxacin inhibits vacuolar H+ ATPase activity, preventing bone resorption.

Product Info

Cas No.

74011-58-8

Purity

≥98%

Formula

C15H17FN4O3

Formula Wt.

320.32

Chemical Name

1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid

IUPAC Name

1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,8-naphthyridine-3-carboxylic acid

Synonym

Abenox, Bactidan, Comprecin, Flumark, Penetrex

Melting Point

220-224°C

Solubility

Insoluble in water.

Appearance

Yellow to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

E5358 MSDS PDF

Info Sheet

E5358 Info Sheet PDF

References

Liu X, Qu X, Wu C, et al. The effect of enoxacin on osteoclastogenesis and reduction of titanium particle-induced osteolysis via suppression of JNK signaling pathway. Biomaterials. 2014 Jul;35(22):5721-30. PMID: 24767789.

Toro EJ, Zuo J, Ostrov DA, et al. Enoxacin directly inhibits osteoclastogenesis without inducing apoptosis. J Biol Chem. 2012 May 18;287(21):17894-904. PMID: 22474295.

Zuma AA, Cavalcanti DP, Maia MC, et al. Effect of topoisomerase inhibitors and DNA-binding drugs on the cell proliferation and ultrastructure of Trypanosoma cruzi. Int J Antimicrob Agents. 2011 May;37(5):449-56. PMID: 21292448.

Koseki N, Deguchi J, Yamashita A, et al. Establishment fo a novel experimental protocol for drug-induced seizure liability screening based on a locomotor activity assay in zebrafish. J Toxicol Sci. 2014 Aug;39(4):579-600. PMID: 25056783.

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