Epothilone D

Name: Epothilone D
SKU: E6356
Availability: InStock

Product ID E6356

Cas No. 189453-10-9

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Epothilone is an anticancer chemotherapeutic that acts as an anti-mitotic compound; it binds the taxane pocket of β-tubulin, using side chains to induce formation of a short helix and preventing microtubule depolymerization. Epothilone displays activity against lung cancer and prostate cancer in clinical trials and may show benefit in treatment of neurodegenerative diseases such as Alzheimer’s disease. Typically, the degree of chemotherapeutic activity of the three epothilone subtypes follows the alphabet, where Epo A> Epo B> Epo D.

Product Info

Cas No.	189453-10-9
Purity	≥98%
Formula	C₂₇H₄₁NO₅S
Formula Wt.	491.68
Chemical Name	(4S,7R,8S,9S,13Z,16S)-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-1-oxacyclohexadec-13-ene-2,6-dione
IUPAC Name	(4S,7R,8S,9S,13Z,16S)-4,8-dihydroxy-5,5,7,9, 13-pentamethyl-16-[(E)-1-(2-methyl-1, 3-thiazol-4-yl)prop-1-en-2-yl]-1-oxacyclohexadec-13-ene-2,6-dione
Synonym	Desoxyepothilone b
Appearance	White to off white powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	E6356 MSDS PDF
Info Sheet	E6356 Info Sheet PDF

References

Prota AE, Bargsten K, Zurwerra D, et al. Molecular mechanism of action of microtubule-stabilizing anticancer agents. Science. 2013 Feb 1;339(6119):587-90. PMID: 23287720.

Entwistle RA, Rizk RS, Cheng DM, et al. Differentiating between models of epothilone binding to microtubules using tubulin mutagenesis, cytotoxicity, and molecular modeling. ChemMedChem. 2012 Sep;7(9):1580-6. PMID: 22807375.

Edelman MJ, Shvartsbeyn M. Epothilones in development for non--small-cell lung cancer: novel anti-tubulin agents with the potential to overcome taxane resistance. Clin Lung Cancer. 2012 May;13(3):171-80. PMID: 22133291

Kelly WK. Epothilones in prostate cancer. Urol Oncol. 2011 Jul-Aug;29(4):358-65. PMID: 19914096.

Lee JJ, Kelly WK. Epothilones: tubulin polymerization as a novel target for prostate cancer therapy. Nat Clin Pract Oncol. 2009 Feb;6(2):85-92. PMID: 19048010.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Comments
This field is for validation purposes and should be left unchanged.

Epothilone D

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Palmitoyl-L-carnitine

Diclofenac Related Compound A

Fluocinolone Acetonide

Flutriafol

Nivalenol

Mastoparan X

Nifedipine

Clemizole Hydrochloride

Phentolamine Hydrochloride

Nobiletin

Amlodipine

n-Butyl Analog of Paclitaxel

Tenuazonic Acid Copper Salt

GNE-7915

Salmeterol

Erythromycin Resistance Peptide MRLFV

Guggulsterone

Penicillin V Potassium

Piperlongumine

Tetrodotoxin Citrate

Footer