• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Epothilone D

Epothilone D

Product ID E6356
Cas No. 189453-10-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $112.20 In stock
5 mg $245.30 In stock
10 mg $428.70 In stock
25 mg $918.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Epothilone is an anticancer chemotherapeutic that acts as an anti-mitotic compound; it binds the taxane pocket of β-tubulin, using side chains to induce formation of a short helix and preventing microtubule depolymerization. Epothilone displays activity against lung cancer and prostate cancer in clinical trials and may show benefit in treatment of neurodegenerative diseases such as Alzheimer’s disease. Typically, the degree of chemotherapeutic activity of the three epothilone subtypes follows the alphabet, where Epo A> Epo B> Epo D.

Product Info

Cas No.

189453-10-9

Purity

≥98%

Formula

C27H41NO5S

Formula Wt.

491.68

Chemical Name

(4S,7R,8S,9S,13Z,16S)-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-1-oxacyclohexadec-13-ene-2,6-dione

IUPAC Name

(4S,7R,8S,9S,13Z,16S)-4,8-dihydroxy-5,5,7,9, 13-pentamethyl-16-[(E)-1-(2-methyl-1, 3-thiazol-4-yl)prop-1-en-2-yl]-1-oxacyclohexadec-13-ene-2,6-dione

Synonym

Desoxyepothilone b

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

E6356 MSDS PDF

Info Sheet

E6356 Info Sheet PDF

References

Prota AE, Bargsten K, Zurwerra D, et al. Molecular mechanism of action of microtubule-stabilizing anticancer agents. Science. 2013 Feb 1;339(6119):587-90. PMID: 23287720.

Entwistle RA, Rizk RS, Cheng DM, et al. Differentiating between models of epothilone binding to microtubules using tubulin mutagenesis, cytotoxicity, and molecular modeling. ChemMedChem. 2012 Sep;7(9):1580-6. PMID: 22807375.

Edelman MJ, Shvartsbeyn M. Epothilones in development for non--small-cell lung cancer: novel anti-tubulin agents with the potential to overcome taxane resistance. Clin Lung Cancer. 2012 May;13(3):171-80. PMID: 22133291

Kelly WK. Epothilones in prostate cancer. Urol Oncol. 2011 Jul-Aug;29(4):358-65. PMID: 19914096.

Lee JJ, Kelly WK. Epothilones: tubulin polymerization as a novel target for prostate cancer therapy. Nat Clin Pract Oncol. 2009 Feb;6(2):85-92. PMID: 19048010.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A1369

    Adrenomedullin (13-52), human

    Endogenous peptide hormone, involved in cell gr...

    ≥95%
  • T3324

    Tigecycline

    Glycylcycline; protein synthesis inhibitor.

    ≥98%
  • C2968

    Chrysin

    Flavone found in Passiflora, Oroxylum, and Pleu...

    ≥98%
  • W2933

    WHI-P131

    JAK3 and EGFR inhibitor.

    ≥99%
  • A7400

    ASP3026

    ALK inhibitor.

    ≥98%
  • E5576

    Entecavir

    Nucleoside (deoxyguanosine) analog; DNA chain t...

    ≥97%
  • R0253

    Ranitidine Hydrochloride

    Histamine H2 inverse agonist.

    ≥98%
  • G4781

    Glucoraphanin Potassium

    Glucosinolate found in cruciferous vegetables.<...

    ≥98%
  • N8662

    NVP-BGJ398

    FGFR inhibitor.

    ≥98%
  • S0133

    Saikosaponin C

    Triterpene saponin found in Bupleurum.

    ≥98%
  • G4580

    Glucosamine Hydrochloride

    Endogenous amino sugar precursor required for p...

    ≥96%
  • D3352

    Dinaciclib

    BRD binding agent, CDK1/2/5/9 inhibitor.

    ≥99%
  • T8269

    (S)-ar-Turmerone

    Sesquiterpene found in Curcuma.

    ≥97%
  • M9367

    Myricetin

    Flavonol found in fruits and vegetables; COMT i...

    ≥98%
  • C4000

    CK-636

    Arp2/3 inhibitor.

    ≥98%
  • T5672

    Tosufloxacin Tosylate

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • A0822

    N-Acetyl-S-(N-methylsulfinylbutylthiocarbamoyl)-L-cysteine

    Sulforaphane-cysteine conjugate.

    ≥98%
  • P7021

    Prednisone Acetate

    Synthetic prednisolone prodrug; glucocorticoid ...

    ≥98%
  • C5655

    α-Conotoxin GI

    Peptide toxin found in Conus snails; nAChR inhi...

    ≥95%
  • N1977

    Neurokinin A (4-10)

    Endogenous neuropeptide, also known as substanc...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only