• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
EPZ6438

EPZ6438

Product ID E6397
Cas No. 1403254-99-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $60.10 In stock
5 mg $112.60 In stock
25 mg $297.50 In stock
100 mg $901.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

EPZ-6438 is an inhibitor of EZH2, a histone methyltransferase (HMT) responsible for methylation of lysine and arginine residues and controls gene transcription fidelity in cells. EPZ-6438 displays anticancer chemotherapeutic activity in in vivo models by inducing regression of malignant or atypical teratoid rhabdoid tumors containing altered or mutant SWI/SNF ATP-dependent chromatin remodelers.

Product Info

Cas No.

1403254-99-8

Purity

≥98%

Formula

C34H44N4O4

Formula Wt.

572.74

Chemical Name

N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-[4-(morpholin-4-ylmethyl)phenyl]benzamide

IUPAC Name

N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-[4-(morpholin-4-ylmethyl)phenyl]benzamide

Synonym

E7438, Tazemetostat,

Solubility

DMSO 5 mg/mL warmed (8.72 mM) Water Insoluble Ethanol Insoluble

Appearance

white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

E6397 MSDS PDF

Info Sheet

E6397 Info Sheet PDF

Brochures

Epigenetic Modifiers Booklet

References

Knutson SK, Warholic NM, Wigle TJ, et al. Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7922-7. PMID: 23620515.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • F0048

    Famciclovir

    Penciclovir prodrug, nucleoside (guanosine) ana...

    ≥98%
  • W0273

    R-(+)-Warfarin >99%ee

    Coumarin; VKORC1 inhibitor.

    ≥99%
  • V014451

    Valiltramiprosate

    beta-Amyloid anti-oligomer and aggregation inhi...

    ≥99%
  • K0276

    Katacalcin

    Peptide found in crustaceans; PKA activator.

    ≥95%
  • B8248

    Bumetanide

    Loop diuretic; NKCC symporter and KCC2 co-trans...

    ≥98%
  • A9710

    AZD-2014

    mTOR inhibitor.

    ≥98%
  • R8076

    Rutin Hydrate

    Flavonoid glycoside found in fruit, asparagus, ...

    ≥95%
  • R5772

    Rosiglitazone Maleate

    Thiazolidinedione; PPARγ agonist.

    ≥98%
  • A2401

    AG-18

    EGFR and PDGFR inhibitor

    ≥98%
  • D582705

    Dorsomorphin Dihydrochloride

    Inhibitor of ALK2, ALK3, ALK6, and AMPK.

    ≥98%
  • G0244

    alpha-Galactosylceramide

    Synthetic glycolipid found in Agelas mauritaniu...

    ≥96%
  • T0253

    Tangeretin

    Polymethoxy flavonoid found in citrus fruits.

    ≥98%
  • A4578

    Altretamine

    DNA alkylator.

    ≥98%
  • A971336

    Azilsartan Medoxomil

    Prodrug

    ≥98%
  • A4646

    ALLN

    Calpain I/II inhibitor.

    ≥98%
  • B8074

    3-tert-Butyl-5-Methoxy-1,2-quinone

    BHA derivative.

    ≥98%
  • U682042

    URB602

    Inhibitor of Monoacyglycerol lipase (MAGL).

    ≥98%
  • V0376

    Vatalanib Dihydrochloride

    VEGFR inhibitor.

    ≥98%
  • A985136

    AZD5991

    Mcl-1 inhibitor

    ≥99%
  • H9712

    (E)-4-Hydroxytamoxifen

    SERM.

    ≥97%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only