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Fenofibrate

Fenofibrate

Product ID F1853
Cas No. 49562-28-9
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $63.90 In stock
25 g $187.40 In stock
100 g $385.90 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Fenofibrate is a fibric acid derivative fibrate compound that exhibits anti-hyperlipidemic, anti-fibrotic, and anticancer chemotherapeutic activities. Fenofibrate activates PPARα, stimulating lipoprotein lipase and increasing lipolysis; this results in decreases in overall triglyceride, VLDL, and LDL levels as well as increases in HDL levels. Fenofibrate decreases oxidative stress-induced expression of α-SMA, TGF-β1, IL-6, collagen-1, and TNF-α, preventing CCL4-induced hepatic fibrosis. Fenofibrate also upregulates expression of Bad, downregulates expression of Bcl-xl, survivin, cyclin D1, and CDK4, activates caspase-3 and NF-κB, and induces G0/G1 phase cell cycle arrest in breast cancer cells, suppressing cell and tumor growth in both in vitro and in vivo models.

Product Info

Cas No.

49562-28-9

Purity

≥98%

Formula

C20H21ClO4

Formula Wt.

360.83

Chemical Name

2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid 1-methylethyl ester

IUPAC Name

propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate

Synonym

Ankebin, Elasterin, Fempbrate, Lipantil, Lipoclar, Lipofene, Nolipax, Secalip, Tricor

Melting Point

80-81°C

Solubility

Soluble in acetone, ether, benzene and chloroform. Slightly soluble in methanol and ethanol. Practically insoluble in water.

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

F1853 MSDS PDF

Info Sheet

F1853 Info Sheet PDF

References

Gao Y, Shen W, Zhang Q, et al. Up-regulation of Hepatic VLDLR via PPARα Is Required for the Triglyceride-Lowering Effect of Fenofibrate. J Lipid Res. 2014 Jun 4. [Epub ahead of print]. PMID: 24899625.

Li T, Zhang Q, Zhang J, et al. Fenofibrate induces apoptosis of triple-negative breast cancer cells via activation of NF-κB pathway. BMC Cancer. 2014 Feb 16;14:96. PMID: 24529079.

Xie C, Li L, Xu YP, et al. Anti-fibrosis effects of fenofibrate in mice with hepatic fibrosis. Zhonghua Gan Zang Bing Za Zhi. 2013 Dec;21(12):914-9. PMID: 24636293.

Custom Order

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  • This field is for validation purposes and should be left unchanged.

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