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Fisetin

Fisetin

Product ID F3473
Cas No. 528-48-3
Purity ≥97%
Product Unit SizeCostQuantityStock
100 mg $75.10 In stock
500 mg $105.30 In stock
1 g $188.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Fisetin is a flavonoid found in various plant sources that exhibits neuroprotective, cognition enhancing, antioxidative, immunosuppressive, anti-angiogenic, and anticancer activities. In animal models of Alzheimer’s disease, fisetin decreases levels of p25 and increases phosphorylation of ERK, resulting in fewer deficits in learning and memory. In cellular models, fisetin decreases levels of H2O2-generated superoxide anions, hydroxyl radicals, and ROS. Fisetin activates sirtuins, displaying anti-aging potential. In animal models, this compound prevents delayed-type hypersensitivity reactions; in related cellular models, fisetin inhibits Th1/Th2 cytokine production, activation of NF-κB, and signaling by nuclear factor of activated T cells (NFAT). In various cell lines, fisetin inhibits matrix metalloproteinases 1, 3, 7, 9, and 14, inhibiting tube/vessel formation and cell proliferation. In nasopharyngeal carcinoma cells, fisetin inhibits the epithelial-to-mesenchymal transition (EMT), preventing cell migration and invasion. This compound also inhibits topoisomerases I and II.

Product Info

Cas No.

528-48-3

Purity

≥97%

Formula

C15H10O6

Formula Wt.

286.24

Chemical Name

2-(3,4-dihydroxyphenyl)-3,7-dihydroxychromen-4-one

IUPAC Name

2-(3,4-dihydroxyphenyl)-3,7-dihydroxychromen-4-one

Synonym

3,3',4',7-Tetrahydroxyflavone

Melting Point

330°C

Appearance

Light yellow powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

F3473 MSDS PDF

Info Sheet

F3473 Info Sheet PDF

References

Li R, Zhao Y, Chen J, et al. Fisetin inhibits migration, invasion and epithelial-mesenchymal transition of LMP1-positive nasopharyngeal carcinoma cells. Mol Med Rep. 2014 Feb;9(2):413-8. PMID: 24297333.

Currais A, Prior M, Dargusch R, et al. Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice. Aging Cell. 2013 Dec 17. [Epub ahead of print]. PMID: 24341874.

Park JH, Jang YJ, Choi YJ, et al. Fisetin inhibits matrix metalloproteinases and reduces tumor cell invasiveness and endothelial cell tube formation. Nutr Cancer. 2013;65(8):1192-9. PMID: 24099040.

Song B, Guan S, Lu J, et al. Suppressive effects of fisetin on mice T lymphocytes in vitro and in vivo. J Surg Res. 2013 Nov;185(1):399-409. PMID: 23993202.

Kang KA, Piao MJ, Kim KC, et al. Fisetin attenuates hydrogen peroxide-induced cell damage by scavenging reactive oxygen species and activating protective functions of cellular glutathione system. In Vitro Cell Dev Biol Anim. 2013 Aug 27. [Epub ahead of print]. PMID: 23982916.

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