LKT Labs

Biochemicals for Life Science Research

Flavokawain A

Product ID F4502
Cas No. 64680-84-8
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $216.00 In stock
10 mg $333.70 In stock
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Description

Flavokawain A is a chalcone kavalactone originally found in Piper methysticum (kava plant). Flavokawain A exhibits anti-inflammatory and anticancer chemotherapeutic activities. This compound inhibits degradation of IκBα and activation of NF-κB; it also inhibits expression of iNOS and COX-2 in macrophages as well as activity of IκK, PRAK, MAPKAP-K3, DYRK1A, and AurB. In vivo, flavokawain A inhibits urothelial cell carcinoma, decreasing expression of Ki67, XIAP, and survivin, and increasing expression of DR5 and p27.

Product Info

Cas No.

64680-84-8
Purity

≥98%
Formula

C18H18O5
Formula Wt.

314.33
IUPAC Name

1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
Melting Point

112-116°C
Solubility

DMSO 100 mM. Insoluble in water. Soluble in methanol.
Appearance

Yellow crystalline powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

F4502 MSDS PDF
Info Sheet

F4502 Info Sheet PDF

References

Liu Z, Xu X, Li X, et al. Kava chalcone, flavokawain A, inhibits urothelial tumorigenesis in the UPII-SV40T transgenic mouse model. Cancer Prev Res (Phila). 2013 Dec;6(12):1365-75. PMID: 24121102.

Kwon DJ, Ju SM, Youn GS, et al. Suppression of iNOS and COX-2 expression by flavokawain A via blockade of NF-κB and AP-1 activation in RAW 264.7 macrophages. Food Chem Toxicol. 2013 Aug;58:479-86. PMID: 23727179.

Folmer F, Blasius R, Morceau F, et al. Inhibition of TNFalpha-induced activation of nuclear factor kappaB by kava (Piper methysticum) derivatives. Biochem Pharmacol. 2006 Apr 14;71(8):1206-18. PMID: 16464438.

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