• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Fludarabine Phosphate

Fludarabine Phosphate

Product ID F4782
Cas No. 75607-67-9
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $71.50 In stock
10 mg $102.00 In stock
25 mg $245.30 In stock
100 mg $653.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Fludarabine is a purine nucleoside analog of adenosine that exhibits anti-inflammatory, immunosuppressive, and anticancer chemotherapeutic activities. Fludarabine is clinically used to treat acute myelogenous leukemia (AML), chronic lymphocytic leukemia (CLL), and other lymphoid malignancies. Fludarabine is also used to prevent graft-versus-host disease (GVHD) during hematopoietic stem cell transplantation. Fludarabine is incorporated into DNA and RNA, inhibiting ribonucleotide reductase, DNA polymerase, DNA ligase, and DNA primase, preventing DNA repair and synthesis. In Jurkat T cells, fludarabine inhibits TNF-α-stimulated production of IL-2 and IFN-γ and degradation of IκB kinase, inhibiting activity of NF-κB. In other in vitro models, fludarabine induces apoptosis and inhibits cell growth. Additionally, this compound binds and activates A1 adenosine receptors.

Product Info

Cas No.

75607-67-9

Purity

≥98%

Formula

C10H13FN5O7P

Formula Wt.

365.21

IUPAC Name

[(2R,3S,4S,5R)-5-(6-amino-2-fluoropurin-9-yl)-3, 4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate

Synonym

F-ara-A

Solubility

Slightly soluble in water (6 mg/mL). Soluble in DMSO (70 mg/mL)

Appearance

White to pale yellowish crystalline powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

F4782 MSDS PDF

Info Sheet

F4782 Info Sheet PDF

References

Robak P and Robak T. Older and new purine nucleoside analogs for patients with acute leukemias. Cancer Treat Rev. 2013 Dec;39(8):851-61. PMID: 23566572.

Jensen K, Johnson LA, Jacobson PA, et al. Cytotoxic purine nucleoside analogues bind to A1, A2A, and A3 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol. 2012 May;385(5):519-25. PMID: 22249336.

Nishioka C, Ikezoe T, Togitani K, et al. Fludarabine induces growth arrest and apoptosis of cytokine- or alloantigen-stimulated peripheral blood mononuclear cells, and decreases production of Th1 cytokines via inhibition of nuclear factor kappaB. Bone Marrow Transplant. 2008 Feb;41(3):303-9. PMID: 17994120.

Gandhi V, Plunkett W. Cellular and clinical pharmacology of fludarabine. Clin Pharmacokinet. 2002;41(2):93-103. PMID: 11888330.

Yamauchi T, Nowak BJ, Keating MJ, et al. DNA repair initiated in chronic lymphocytic leukemia lymphocytes by 4-hydroperoxycyclophosphamide is inhibited by fludarabine and clofarabine. Clin Cancer Res. 2001 Nov;7(11):3580-9. PMID: 11705880.

Catapano CV, Perrino FW, Fernandes DJ. Primer RNA chain termination induced by 9-beta-D-arabinofuranosyl-2-fluoroadenine 5'-triphosphate. A mechanism of DNA synthesis inhibition. J Biol Chem. 1993 Apr 5;268(10):7179-85. PMID: 7681821.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • K040007

    KB-0742

    CDK9 inhibitor.

    ≥98%
  • L943721

    LXS-196

    Selective inhibitor of protein kinase C (PKC).<...

    ≥98%
  • R0253

    Ranitidine Hydrochloride

    Histamine H2 inverse agonist.

    ≥98%
  • B1753

    Benfotiamine

    Thiamine/vitamin B derivative, antioxidant.

    ≥98%
  • A1017

    Aceclofenac

    Diclofenac analog, NSAID; COX-2 inhibitor.

    ≥98%
  • C2540

    CGK 733

    ATM and ATR inhibitor.

    ≥98%
  • S8014

    Substance P, Free Acid

    Endogenous tachykinin peptide, involved in infl...

    ≥95%
  • T3033

    Thienyldodecyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥98%
  • O0977

    Octopamine Hydrochloride

    Endogenous biogenic amine, norepinephrine-like ...

    ≥98%
  • H174466

    Helvolic acid

    A fungal metabolite that inhibits protein synthesi...
    ≥98%
  • V0045

    Valacyclovir Hydrochloride

    Neuraminidase inhibitor.  
    ≥98%
  • M0255

    Manzamine A

    Alkaloid found in marine sponges; vacuolar ATPa...

    ≥98%
  • D3449

    Dimethoxycurcumin

    Curcumin derivative.

    ≥98%
  • T3324

    Tigecycline

    Glycylcycline; protein synthesis inhibitor.

    ≥98%
  • A0534

    Abiraterone

    Progesterone derivative; Cyp17A1 inhibitor.

    ≥99%
  • S5753

    Somatostatin-28 (1-14)

    Endogenous neuropeptide hormone; somatostatin a...

    ≥95%
  • L1616

    LEE-011

    CDK4/6 inhibitor.

    ≥98%
  • D1624

    Deflazacort

    Oxazoline; glucocorticoid agonist.

    ≥98%
  • M568268

    Mogroside IV

    Triterpenoid

    ≥98%
  • C294458

    Chlorzoxazone

    Centrally acting muscle relaxant.

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only