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Fluocinolone is a synthetic hydrocortisone derivative that exhibits anti-inflammatory and anti-pruritic activities. Fluocinolone is a corticosteroid that is clinically used to treat ocular inflammation. In dental pulp cells, fluocinolone downregulates expression of pro-inflammatory cytokines and upregulates expression of PPARγ.
| Cas No. | 67-73-2 |
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| Purity | ≥98% |
| Formula | C24H30F2O6 |
| Formula Wt. | 452.49 |
| Chemical Name | (6α,11β,16α)-6,9-Difluoro-11,21-dihydroxy-16,17- [(91-methylethylidene)bis(oxy)]-pregna-1,4-diene- 3,20-dione |
| IUPAC Name | (1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one |
| Synonym | Coriphate, Dermalar, Fluonid, Fluvean, Jellin, Synalar, Synemol, Synsac |
| Melting Point | 265-266°C |
| Solubility | Slightly soluble in water (<1 mg/mL). Ethanol (22 mg/mL). |
| Appearance | White/Almost White crystalline powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
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| Info Sheet |
Cunha-Vaz J, Ashton P, Iezzi R, et al. Sustained Delivery Fluocinolone Acetonide Vitreous Implants: Long-Term Benefit in Patients with Chronic Diabetic Macular Edema. Ophthalmology. 2014 Jun 13. [Epub ahead of print]. PMID: 24935282.
Liu Z, Jiang T, Wang X, et al. Fluocinolone acetonide partially restores the mineralization of LPS-stimulated dental pulp cells through inhibition of NF-κB pathway and activation of AP-1 pathway. Br J Pharmacol. 2013 Nov;170(6):1262-71. PMID: 24024985.