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Fluphenazine Hydrochloride

Fluphenazine Hydrochloride

Product ID F4584
Cas No. 146-56-5
Purity ≥97%
Product Unit SizeCostQuantityStock
250 mg $58.50 In stock
1 g $116.80 In stock
5 g $243.10 In stock
25 g $551.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Fluphenazine is a typical piperazine antipsychotic that is clinically used to treat schizophrenia, bipolar disorder, and dementia. Fluphenazine acts as an antagonist at D2 receptors. Fluphenazine also exhibits arrhythmogenic activity, increasing action potential duration and inducing QT prolongation by decreasing current amplitude of human ether-related-a-go-go (hERG) K+ channels. This compound acts as a functional inhibitor of acid sphingomyelinase (FIASMA).

Product Info

Cas No.

146-56-5

Purity

≥97%

Formula

C22H26F3N3OS • 2HCl

Formula Wt.

510.44

Chemical Name

1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)phenothiazin- 10-yl)propyl)-

IUPAC Name

2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl] ethanol;dihydrochloride

Synonym

Dapotum, Elinol, Fluorfenazine, Fluorophenazine, Pacinol, Moditen.

Solubility

Soluble in water (>100 mg/L), ethanol (149 mg/mL)

Appearance

White or near-white crystalline powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

F4584 MSDS PDF

Info Sheet

F4584 Info Sheet PDF

References

Hong HK, Lee BH, Park MH, et al. Block of hERG K+ channel and prolongation of action potential duration by fluphenazine at submicromolar concentration. Eur J Pharmacol. 2013 Feb 28;702(1-3):165-73. PMID: 23395964.

Pickar D, Owen RR, Litman RE, et al. Clinical and biologic response to clozapine in patients with schizophrenia. Crossover comparison with fluphenazine. Arch Gen Psychiatry. 1992 May;49(5):345-53. PMID: 1375019.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
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