• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
FSL-1

FSL-1

Product ID F7444
Cas No. 322455-70-9
Purity ≥98%
Product Unit SizeCostQuantityStock
100 µg $367.50 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

FSL-1 is an agonist at toll-like receptors (TLR 2/6) that exhibits immunostimulatory, pro-inflammatory, and anticancer activities. FSL-1 increases IgE and IgA responses to foods during systemic antigenic challenge. In vitro, this compound increases expression and activity of MMP-9, IL-6, IL-9, and COX-2. FSL-1 is also used as an adjuvant, in which it induces a Th2-specific response by increasing IgA and IgG levels. FSL-1 also increases tumor size when given alone, but if combined with tumor-specific antigens, decreases tumor size by stimulating production of antigen-specific cytotoxic T lymphocytes, antibodies, and NK cells.

Product Info

Cas No.

322455-70-9

Purity

≥98%

Formula

C84H140N14O18S

Formula Wt.

1666.2

Chemical Name

(R,S)-Pam2Cys-Gly-Asp-Pro-Lys-His-Pro-Lys-Ser-Phe-OH

Synonym

Fibroblast-stimulating Lipopeptide, Pam2CGDPKHPKSF, (R,S)-Pam2Cys-Gly-Asp-Pro-Lys-His-Pro-Lys-Ser-Phe-OH

Solubility

Soluble in water (10mg/ml). Use a homogeniser or sonicator to prepare a homogenous solution.

Appearance

Colorless powder.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

F7444 MSDS PDF

Info Sheet

F7444 Info Sheet PDF

References

Tunis MC, Dawod B, Carson KR, et al. Toll-like receptor 2 activators modulate oral tolerance in mice. Clin Exp Allergy. 2015 Aug 4. [Epub ahead of print]. PMID: 26242919.

Lim R, Barker G, Lappas M. The TLR2 ligand FSL-1 and the TLR5 ligand Flagellin mediate pro-inflammatory and pro-labour response via MyD88/TRAF6/NF-κB-dependent signalling. Am J Reprod Immunol. 2014 May;71(5):401-17. PMID: 24635133.

Buffa V, Klein K, Fischetti L, et al. Evaluation of TLR agonists as potential mucosal adjuvants for HIV gp140 and tetanus toxoid in mice. PLoS One. 2012;7(12):e50529. PMID: 23272062.

Kiura K, Hasebe A, Saeki A, et al. In vivo anti- and pro-tumour activities of the TLR2 ligand FSL-1. Immunobiology. 2011 Aug;216(8):891-900. PMID: 21496943.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • Z4833

    ZM-336372

    c-Raf inhibitor, tyrosine kinase inhibitor.

    ≥98%
  • G0245

    Gallocatechin Gallate

    Polyphenol found in Camilla sinensis; HIV integ...

    ≥98%
  • G5874

    Gossypol

    Polyphenol found in Gossypium; calcineurin and ...

    ≥98%
  • P1755

    Pentoxifylline

    Xanthine derivative; adenosine A2 antagonist, P...

    ≥98%
  • H8162

    (−)-Huperzine A

    Sesquiterpene alkaloid found in Huperzia serrat...

    ≥97%
  • C0274

    Caspofungin Diacetate

    Lipopeptide; 1,3-β-Glucan synthase inhibitor.<...

    ≥95%
  • E6993

    Erythromycin Resistance Peptide MRLFV

    Peptide, confers resistance against macrolide a...

    ≥95%
  • A2077

    Afatinib

    EGFR inhibitor.

    ≥98%
  • A0099

    A-779

    Mas antagonist.

    ≥95%
  • C084099

    CCCP

    Efflux pump inhibitor

    ≥99%
  • L582694

    Lorlatinib

    Third generation macrocyclic ALK inhibitor.

    ≥98%
  • T3200

    Ticagrelor

    Nucleoside (adenosine) analog; P2Y12 antagonist...

    ≥98%
  • D3352

    Dinaciclib

    BRD binding agent, CDK1/2/5/9 inhibitor.

    ≥99%
  • A0958

    Aconitine

    Toxin found in Aconitum; voltage-gated Na+ chan...

    ≥95%
  • E6814

    Erdosteine

    Thiol derivative, antioxidant.

    ≥98%
  • C0169

    Carbenoxolone Disodium

    Synthetic derivative of glycyrrhizin; connexin ...

    ≥97%
  • S0044

    Salbutamol Free Base

    β2-adrenergic agonist.

    ≥98%
  • A040068

    AB-680

    CD73 inhibitor

    ≥98%
  • S771339

    STING Agonist-12

    STING activator

    ≥99%
  • N3478

    Nitrendipine

    Calcium channel blocker.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only