LKT Labs

Biochemicals for Life Science Research

Fumagillin

Fumagillin

Product ID F8048
Cas No. 23110-15-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $85.10 In stock
5 mg $283.60 In stock
Bulk Quote

Quicklinks

Description

Fumagillin is an antimicrobial compound initially produced by species of Aspergillus that exhibits anti-parasitic, antimalarial, anti-fibrotic, anti-angiogenic, and anticancer chemotherapeutic activities. Fumagillin is clinically used to treat microsporidiosis and displays efficacy against Plasmodium, Nosema, and Enterocytozoon. In vivo, fumagillin decreases pulmonary fibrosis, pulmonary hypertension, and ventricular remodeling. In cellular and animal models of colorectal cancer, fumagillin inhibits type 2 methionine aminopeptidase, preventing tube and vessel formation and well as cell proliferation, migration, and adhesion; it also decreases tumor mass.

Product Info

Cas No.

23110-15-8
Purity

≥98%
Formula

C26H34O7
Formula Wt.

458.54
Chemical Name

[3R-[3α,4α(2R*,3R*),5β,6β(all-E)]]-2,4,6,8-Decatetra- enedioic acid, mono[5-methoxy-4-[2-methyl-3-(3- methyl- 2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl] ester
IUPAC Name

(2Z,4E,6E, 8E)-10-[[5-methoxy-4-[2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1- oxaspiro[2.5]octan-6-yl]oxy]-10-oxodeca-2,4,6,8-tetraenoic acid
Synonym

Amebacilin, Fugillin, Fumadil B: Fumidil

Melting Point

194-195°C
Solubility

Soluble in most organic solvents. Practically insoluble in water, dilute acids and saturated hydrocarbons.

Appearance

Off white Powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

F8048 MSDS PDF
Info Sheet

F8048 Info Sheet PDF

References

Kass DJ, Rattigan E, Kahloon R, et al. Early treatment with fumagillin, an inhibitor of methionine aminopeptidase-2, prevents Pulmonary Hypertension in monocrotaline-injured rats. PLoS One. 2012;7(4):e35388. PMID: 22509410.

Champion L, Durrbach A, Lang P, et al. Fumagillin for treatment of intestinal microsporidiosis in renal transplant recipients. Am J Transplant. 2010 Aug;10(8):1925-30. PMID: 20636462.

Arico-Muendel C, Centrella PA, Contonio BD, et al. Antiparasitic activities of novel, orally available fumagillin analogs. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5128-31. PMID: 19648008.

Hou L, Mori D, Takase Y, et al. Fumagillin inhibits colorectal cancer growth and metastasis in mice: in vivo and in vitro study of anti-angiogenesis. Pathol Int. 2009 Jul;59(7):448-61. PMID: 19563408.

Chen X, Xie S, Bhat S, et al. Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo. Chem Biol. 2009 Feb 27;16(2):193-202. PMID: 19246010.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A1017

    Aceclofenac

    Diclofenac analog, NSAID; COX-2 inhibitor.

    ≥98%
  • B1753

    Benfotiamine

    Thiamine/vitamin B derivative, antioxidant.

    ≥98%
  • B1955

    Benztropine Mesylate

    DAT inhibitor.

    ≥99%
  • T5605

    Tobramycin Sulfate

    Aminoglycoside; protein translation inhibitor.<...

    ≥98%
  • B1973

    Besifloxacin Hydrochloride

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • P2000

    PF-03758309 Dihydrochloride

    PAK4 inhibitor.

    ≥99%, ≥99%ee
  • T3031

    Thienylbutyl Isothiocyanate

    ITC.

    ≥96%
  • A4444

    L-Alliin

    Cysteine derivative found in Allium; NMDA NR2A/...

    ≥98%
  • M1877

    Methylprednisolone

    Synthetic steroid; glucocorticoid agonist.

    ≥96%
  • P1634

    Peimine

    Steroidal alkaloid found in Fritillaria; TRPV1 ...

    ≥98%
  • T5720

    Tofacitinib Citrate

    JAK1/2/3 inhibitor.

    ≥99%
  • S1609

    Securinine

    Alkaloid found in Securinega; potential GABA-A ...

    ≥98%
  • S7603

    Stavudine

    Nucleoside (thymidine) analog; DNA chain termin...

    ≥99%
  • D023721

    Dasatinib

    Multikinase inhibitor.

    ≥99%
  • C6132

    CPI-203

    Triazolothienodiazepine, JQ-1 derivative; BRD i...

    ≥98%
  • T564098

    Tocored

    Tocopherol analog
  • T0154

    Tanshinone IIA

    Found in Salvia; MAG lipase inhibitor.

    ≥93%
  • G0250

    cGAMP Disodium [STING Ligand]

    Cyclic dinucleotide that detects cytosolic DNA ...

    ≥98%
  • T3039

    Thienyloctyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥97%
  • K2412

    KGDS

    Synthetic peptide, fibrinogen derivative; glyco...

    ≥95%