LKT Labs

Biochemicals for Life Science Research

Fumagillin

Fumagillin

Product ID F8048
Cas No. 23110-15-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $85.10 In stock
5 mg $283.60 In stock
Bulk Quote

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Description

Fumagillin is an antimicrobial compound initially produced by species of Aspergillus that exhibits anti-parasitic, antimalarial, anti-fibrotic, anti-angiogenic, and anticancer chemotherapeutic activities. Fumagillin is clinically used to treat microsporidiosis and displays efficacy against Plasmodium, Nosema, and Enterocytozoon. In vivo, fumagillin decreases pulmonary fibrosis, pulmonary hypertension, and ventricular remodeling. In cellular and animal models of colorectal cancer, fumagillin inhibits type 2 methionine aminopeptidase, preventing tube and vessel formation and well as cell proliferation, migration, and adhesion; it also decreases tumor mass.

Product Info

Cas No.

23110-15-8
Purity

≥98%
Formula

C26H34O7
Formula Wt.

458.54
Chemical Name

[3R-[3α,4α(2R*,3R*),5β,6β(all-E)]]-2,4,6,8-Decatetra- enedioic acid, mono[5-methoxy-4-[2-methyl-3-(3- methyl- 2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl] ester
IUPAC Name

(2Z,4E,6E, 8E)-10-[[5-methoxy-4-[2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1- oxaspiro[2.5]octan-6-yl]oxy]-10-oxodeca-2,4,6,8-tetraenoic acid
Synonym

Amebacilin, Fugillin, Fumadil B: Fumidil

Melting Point

194-195°C
Solubility

Soluble in most organic solvents. Practically insoluble in water, dilute acids and saturated hydrocarbons.

Appearance

Off white Powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

F8048 MSDS PDF
Info Sheet

F8048 Info Sheet PDF

References

Kass DJ, Rattigan E, Kahloon R, et al. Early treatment with fumagillin, an inhibitor of methionine aminopeptidase-2, prevents Pulmonary Hypertension in monocrotaline-injured rats. PLoS One. 2012;7(4):e35388. PMID: 22509410.

Champion L, Durrbach A, Lang P, et al. Fumagillin for treatment of intestinal microsporidiosis in renal transplant recipients. Am J Transplant. 2010 Aug;10(8):1925-30. PMID: 20636462.

Arico-Muendel C, Centrella PA, Contonio BD, et al. Antiparasitic activities of novel, orally available fumagillin analogs. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5128-31. PMID: 19648008.

Hou L, Mori D, Takase Y, et al. Fumagillin inhibits colorectal cancer growth and metastasis in mice: in vivo and in vitro study of anti-angiogenesis. Pathol Int. 2009 Jul;59(7):448-61. PMID: 19563408.

Chen X, Xie S, Bhat S, et al. Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo. Chem Biol. 2009 Feb 27;16(2):193-202. PMID: 19246010.

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