LKT Labs

Biochemicals for Life Science Research

Fumagillin

Fumagillin

Product ID F8048
Cas No. 23110-15-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $85.00 In stock
5 mg $284.00 In stock
Bulk Quote

Quicklinks

Description

Fumagillin is an antimicrobial compound initially produced by species of Aspergillus that exhibits anti-parasitic, antimalarial, anti-fibrotic, anti-angiogenic, and anticancer chemotherapeutic activities. Fumagillin is clinically used to treat microsporidiosis and displays efficacy against Plasmodium, Nosema, and Enterocytozoon. In vivo, fumagillin decreases pulmonary fibrosis, pulmonary hypertension, and ventricular remodeling. In cellular and animal models of colorectal cancer, fumagillin inhibits type 2 methionine aminopeptidase, preventing tube and vessel formation and well as cell proliferation, migration, and adhesion; it also decreases tumor mass.

Product Info

Cas No.

23110-15-8
Purity

≥98%
Formula

C26H34O7
Formula Wt.

458.54
Chemical Name

[3R-[3α,4α(2R*,3R*),5β,6β(all-E)]]-2,4,6,8-Decatetra- enedioic acid, mono[5-methoxy-4-[2-methyl-3-(3- methyl- 2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl] ester
IUPAC Name

(2Z,4E,6E, 8E)-10-[[5-methoxy-4-[2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1- oxaspiro[2.5]octan-6-yl]oxy]-10-oxodeca-2,4,6,8-tetraenoic acid
Synonym

Amebacilin, Fugillin, Fumadil B: Fumidil

Melting Point

194-195°C
Solubility

Soluble in most organic solvents. Practically insoluble in water, dilute acids and saturated hydrocarbons.

Appearance

Off white Powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

F8048 MSDS PDF
Info Sheet

F8048 Info Sheet PDF

References

Kass DJ, Rattigan E, Kahloon R, et al. Early treatment with fumagillin, an inhibitor of methionine aminopeptidase-2, prevents Pulmonary Hypertension in monocrotaline-injured rats. PLoS One. 2012;7(4):e35388. PMID: 22509410.

Champion L, Durrbach A, Lang P, et al. Fumagillin for treatment of intestinal microsporidiosis in renal transplant recipients. Am J Transplant. 2010 Aug;10(8):1925-30. PMID: 20636462.

Arico-Muendel C, Centrella PA, Contonio BD, et al. Antiparasitic activities of novel, orally available fumagillin analogs. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5128-31. PMID: 19648008.

Hou L, Mori D, Takase Y, et al. Fumagillin inhibits colorectal cancer growth and metastasis in mice: in vivo and in vitro study of anti-angiogenesis. Pathol Int. 2009 Jul;59(7):448-61. PMID: 19563408.

Chen X, Xie S, Bhat S, et al. Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo. Chem Biol. 2009 Feb 27;16(2):193-202. PMID: 19246010.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • I5203

    Inauhzin

    p53 activator, IMPDH and SIRT1 inhibitor.

    ≥98%
  • J766160

    JTE907

    Selective Cannabinoid receptor 2(CB2) inverse a...

    ≥98%
  • D564090

    7-epi-Docetaxel

    Docetaxel impurity

    ≥95%
  • T1655

    Tenoxicam Impurity 1

    Tenoxicam impurity

    ≥98%
  • D3229

    7,8-Dihydrokawain

    Kavalactone originally found in Piper methystic...

    ≥98%
  • L3550

    Limonin

    Furanolactone found in citrus fruits.

    ≥98%
  • C8502

    CV-70

    1,8-Diaza-anthracene-tetrone; JNK and ERK5 inhi...

    ≥70%
  • M184790

    Metyrapone

    Steroidogenesis inhibitor

    ≥98%
  • E6997

    Erythropoietin, Human Recombinant

    Endogenous glycoprotein hormone involved in red...

    ≥97%
  • P9768

    Pyronaridine Tetraphosphate

    Hemantin inhibitor.

    ≥98%
  • C5768

    Corazonin

    Neuropeptide found in insects.

    ≥95%
  • A0978

    Actinonin

    Peptide deformylase, MMP meprin A, aminopeptida...

    ≥98%
  • V9228

    VX-765

    NLRP3 and caspase-1 inhibitor.

    ≥98%
  • P2522

    S-(N-Phenylthiocarbamoyl)-glutathione

    Glutathione-ITC conjugate, antioxidant.

    ≥98%
  • T1672

    Terbinafine Hydrochloride

    Allylamine; squalene oxidase and KSR1 inhibitor...

    ≥98%
  • C0260

    Capsanthin

    Carotenoid originally found in Capsicum. Color ...

    Color value:100
  • T3039

    Thienyloctyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥97%
  • C0344

    Calphostin C

    Found in Cladosporium; PKC inhibitor.

    ≥95%
  • G3353

    Ginkgolic Acid (15:1)

    Found in Ginkgo; HIV protease and fatty acid sy...

    ≥98%
  • G3557

    Ginsenoside Rh1

    Triterpene saponin found in species of Panax.

    ≥77%