Fumagillin

Name: Fumagillin
SKU: F8048
Availability: InStock

Product ID F8048

Cas No. 23110-15-8

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Fumagillin is an antimicrobial compound initially produced by species of Aspergillus that exhibits anti-parasitic, antimalarial, anti-fibrotic, anti-angiogenic, and anticancer chemotherapeutic activities. Fumagillin is clinically used to treat microsporidiosis and displays efficacy against Plasmodium, Nosema, and Enterocytozoon. In vivo, fumagillin decreases pulmonary fibrosis, pulmonary hypertension, and ventricular remodeling. In cellular and animal models of colorectal cancer, fumagillin inhibits type 2 methionine aminopeptidase, preventing tube and vessel formation and well as cell proliferation, migration, and adhesion; it also decreases tumor mass.

Product Info

Cas No.	23110-15-8
Purity	≥98%
Formula	C₂₆H₃₄O₇
Formula Wt.	458.54
Chemical Name	[3R-[3α,4α(2R,3R),5β,6β(all-E)]]-2,4,6,8-Decatetra- enedioic acid, mono[5-methoxy-4-[2-methyl-3-(3- methyl- 2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl] ester
IUPAC Name	(2Z,4E,6E, 8E)-10-[[5-methoxy-4-[2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1- oxaspiro[2.5]octan-6-yl]oxy]-10-oxodeca-2,4,6,8-tetraenoic acid
Synonym	Amebacilin, Fugillin, Fumadil B: Fumidil
Melting Point	194-195°C
Solubility	Soluble in most organic solvents. Practically insoluble in water, dilute acids and saturated hydrocarbons.
Appearance	Off white Powder

Shipping and Storage

Store Temp	4°C
Ship Temp	Ambient

Downloads

MSDS	F8048 MSDS PDF
Info Sheet	F8048 Info Sheet PDF

References

Kass DJ, Rattigan E, Kahloon R, et al. Early treatment with fumagillin, an inhibitor of methionine aminopeptidase-2, prevents Pulmonary Hypertension in monocrotaline-injured rats. PLoS One. 2012;7(4):e35388. PMID: 22509410.

Champion L, Durrbach A, Lang P, et al. Fumagillin for treatment of intestinal microsporidiosis in renal transplant recipients. Am J Transplant. 2010 Aug;10(8):1925-30. PMID: 20636462.

Arico-Muendel C, Centrella PA, Contonio BD, et al. Antiparasitic activities of novel, orally available fumagillin analogs. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5128-31. PMID: 19648008.

Hou L, Mori D, Takase Y, et al. Fumagillin inhibits colorectal cancer growth and metastasis in mice: in vivo and in vitro study of anti-angiogenesis. Pathol Int. 2009 Jul;59(7):448-61. PMID: 19563408.

Chen X, Xie S, Bhat S, et al. Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo. Chem Biol. 2009 Feb 27;16(2):193-202. PMID: 19246010.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Name
This field is for validation purposes and should be left unchanged.

Fumagillin

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Anethole Trithione

Iberverin

Heparin-binding Peptide

Chloroquine Diphosphate

Ginsenoside Re

17-Allylaminogeldanamycin

Mechlorethamine Hydrochloride

Jatrorrhizine

Crystalline peptide

BMS-708163

Brevetoxin 3 42-carboxylic Acid

Ergosterol

Genistein

Kyotorphin

Kemptide

Deoxynivalenol

Demecolcine

Cyproterone Acetate

CFI-400945

6-Aminocaproic Acid

Footer