Description
GDC-0032 inhibits PI3K, exhibiting anticancer chemotherapeutic activity by inhibiting tumor growth in various animal models. This compound also induces G0/G1 phase cell cycle arrest in models of uterine serous carcinoma.
Product Unit Size | Cost | Quantity | Stock |
---|
GDC-0032 inhibits PI3K, exhibiting anticancer chemotherapeutic activity by inhibiting tumor growth in various animal models. This compound also induces G0/G1 phase cell cycle arrest in models of uterine serous carcinoma.
Cas No. | 1282512-48-4 |
---|---|
Purity | ≥98% |
Formula | C24H28N8O2 |
Formula Wt. | 460.53 |
Chemical Name | 2-methyl-2-[4-[2-(5-methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]propanamide |
IUPAC Name | 2-methyl-2-[4-[2-(5-methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]propanamide |
Synonym | GDC0032, Taselisib |
Solubility | DMSO 70 mg/mL warmed (151.99 mM) Water Insoluble Ethanol Insoluble warmed |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Lopez S, Schwab CL, Cocco E, et al. Taselisib, a selective inhibitor of PIK3CA, is highly effective on PIK3CA-mutated and HER2/neu amplified uterine serous carcinoma in vitro and in vivo. Gynecol Oncol. 2014 Nov;135(2):312-7. PMID: 25172762.
Ndubaku CO, Heffron TP, Staben ST, et al. Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): a β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity. J Med Chem. 2013 Jun 13;56(11):4597-610. PMID: 23662903.
NSAID; COX-1/2 and lactate dehydrogenase inhibi...
Anthraquinone found in various plant sources; C...
InsR and IGF-1R inhibitor.
Alkaloid compound originally found in Corydalis...
Vitamin D2, ergocalciferol metabolite; VDR agon...
S-enantiomer of citalopram; SERT inhibitor.
Cell-penetrating peptide, carries large conjuga...
Glycopeptide, vancomycin analog; peptidoglycan ...
Essential vitamin (B2) found in vegetables, dai...
Statin; HMG-CoA reductase inhibitor.
Proteasome inhibitor, miR33b modulator.
Nucleoside antibiotic mixture; GlcNAc phosphotr...
Nucleoside (adenosine) analog; P2Y12 antagonist...
B-Raf and c-Raf inhibitor.
Natriuretic, vasodilatory peptide fragment; B1/...
Mycotoxin, metabolite of aflatoxin B1 produced ...
PKMYT1 inhibitor
FIASMA, σ1, RyR2, TrkA/B agonist; SERT, NET in...
Ca2+-sensing receptor antagonist.