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GDC-0032

GDC-0032

Product ID G1308
Cas No. 1282512-48-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $54.20 In stock
5 mg $117.70 In stock
25 mg $300.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

GDC-0032 inhibits PI3K, exhibiting anticancer chemotherapeutic activity by inhibiting tumor growth in various animal models. This compound also induces G0/G1 phase cell cycle arrest in models of uterine serous carcinoma.

Product Info

Cas No.

1282512-48-4

Purity

≥98%

Formula

C24H28N8O2

Formula Wt.

460.53

Chemical Name

2-methyl-2-[4-[2-(5-methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]propanamide

IUPAC Name

2-methyl-2-[4-[2-(5-methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]propanamide

Synonym

GDC0032, Taselisib

Solubility

DMSO 70 mg/mL warmed (151.99 mM) Water Insoluble Ethanol Insoluble warmed

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G1308 MSDS PDF

Info Sheet

G1308 Info Sheet PDF

References

Lopez S, Schwab CL, Cocco E, et al. Taselisib, a selective inhibitor of PIK3CA, is highly effective on PIK3CA-mutated and HER2/neu amplified uterine serous carcinoma in vitro and in vivo. Gynecol Oncol. 2014 Nov;135(2):312-7. PMID: 25172762.

Ndubaku CO, Heffron TP, Staben ST, et al. Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): a β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity. J Med Chem. 2013 Jun 13;56(11):4597-610. PMID: 23662903.

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