• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Gemcitabine Hydrochloride

Gemcitabine Hydrochloride

Product ID G1745
Cas No. 122111-03-9
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $142.90 In stock
100 mg $428.70 In stock
250 mg $714.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Gemcitabine is a 2’-deoxycytidine analog antimetabolite that inhibits ribonucleotide reductase and DNA synthesis. Gemcitabine exhibits anticancer chemotherapeutic and antiviral activities. In pancreatic cancer cells, gemcitabine induces cell death via mitochondrial complexation of MST1 and cyclophilin D. Additionally, this compound is active against strains of HIV-1 and feline leukemia virus (FeLV/FeLuk).

Product Info

Cas No.

122111-03-9

Purity

≥98%

Formula

C9H11F2N3O4 • HCl

Formula Wt.

299.66

Chemical Name

2'-deoxy-2',2'-difluorocytidine monohydrochloride ((beta)-isomer)

IUPAC Name

4-amino-1-[(2R,4R,5R)-3, 3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one; hydrochloride

Synonym

Gemzar

Melting Point

287-292°C

Solubility

Soluble in water. Slightly soluble in methanol, acetone, DMSO.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

G1745 MSDS PDF

Info Sheet

G1745 Info Sheet PDF

References

Chen SH, Li DL, Yang F, et al. Gemcitabine-induced pancreatic cancer cell death is associated with MST1/Cyclophilin D mitochondrial complexation. Biochimie. 2014 Apr 13. Epub ahead of print]. PMID: 24732633.

Su CH, Chu WC, Lan KH, et al. Gemcitabine causes telomere attrition by stabilizing TRF2. Eur J Cancer. 2012 Dec;48(18):3465-74. PMID: 22704123.

Greggs WM 3rd, Clouser CL, Patterson SE, et al. Discovery of drugs that possess activity against feline leukemia virus. J Gen Virol. 2012 Apr;93(Pt 4):900-5. PMID: 22258856.

Cerqueira NM, Fernandes PA, Ramos MJ. Understanding ribonucleotide reductase inactivation by gemcitabine. Chemistry. 2007;13(30):8507-15. PMID: 17636467.

Blackwood E, Epler J, Yen I, et al. Combination drug scheduling defines a “window of opportunity” for chemopotentiation of gemcitabine by an orally bioavailable, selective ChK1 inhibitor, GNE-900. Mol Cancer Ther. 2013 Oct;12(10):1968-1980. PMID: 23873850.

Reconstituted gemcitabine as the hydrochloride salt in the original vials is chemically stable at room temperature for 35 days but may develop crystals when stored at 4 degrees C. The crystals do not redissolve upon warming. Gemcitabine prepared as intravenous admixtures of 0.1 and 10 mg/mL as the hydrochloride salt in 5% dextrose injection and 0.9% sodium chloride injection in PVC bags and as a solution of 38 mg/mL in 0.9% sodium chloride injection packaged in plastic syringes is physically and chemically stable for at least 35 days at 4 degrees C and 23 degrees C. Gemcitabine as the hydrochloride salt is stable for at least 7 days at concentrations of 0.1, 10, and 38 mg/mL in 5% dextrose injection and 0.9% sodium chloride injection stored at 32 degrees C during simulated ambulatory infusion.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • D1643

    Delta Sleep Inducing Peptide

    Peptide; GABA potentiator, NMDA negative allost...

    ≥95%
  • K1653

    Kendomycin

    Macrolide; ET antagonist, proteasome inhibitor....

    ≥98%
  • S8010

    [Nle11]-Substance P

    Endogenous tachykinin peptide, involved in infl...

    ≥95%
  • O9497

    Oxytocin

    Endogenous neuropeptide hormone, involved in so...

    ≥95%
  • C451338

    Clioquinol

    Antifungal agent with neuroprotective activity....

    ≥98%
  • B5561

    B-type Natriuretic Peptide (1-32), human

    Endogenous cardiomodulatory peptide; NPR-A agon...

    ≥97%
  • A5044

    Amlodipine Besylate

    Dihydropyridine, FIASMA; L-type Ca2+ channel bl...

    ≥98%
  • S0044

    Salbutamol Free Base

    β2-adrenergic agonist.

    ≥98%
  • L5660

    Loperamide Hydrochloride

    FIASMA, μOR agonist, potential HCN channel blo...

    ≥98%
  • E5222

    Endothelin-3, human

    Endogenous peptide, involved in vascular contra...

    ≥95%
  • P0144

    Paliperidone

    D2 and 5-HT2A antagonist.

    ≥97%
  • K1978

    Ketorolac Tromethamine

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • H3277

    Histrelin Acetate

    Peptide, GnRH analog; GnRH agonist.
    ≥95%
  • D6957

    Droloxifene

    Triphenylthylene, tamoxifen analog; SERM.

    ≥98%
  • E7377

    Estriol

    Endogenous steroid hormone, estradiol metabolit...

    ≥97%
  • S7872

    Stresscopin-Related Peptide, human

    Peptide, urocortin II analog; CRFR2 agonist.

    ≥95%
  • S0269

    SAR245409

    Pyridopyrimidinone; PI3K and mTOR inhibitor.

    ≥96%
  • D324094

    Diclofenac Related Compound A

    Impurity of diclofenac

    ≥98%
  • A5234

    Amisulpride

    5-HT7 and D2/3 antagonist.

    ≥98%
  • C2970

    Chrysophanol

    Anthraquinone found in Rheum.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only