• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Gestrinone

Gestrinone

Product ID G1975
Cas No. 16320-04-0
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $92.00 Please Inquire
100 mg $193.90 Please Inquire
500 mg $816.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Gestrinone is a synthetic anti-progestin hormone that acts as an antagonist at estrogen and progesterone receptors and as an agonist at androgen receptors. Gestrinone is primarily used to treat endometriosis in clinical settings; it is also in clinical trials for potential use as an emergency contraceptive. This compound also exhibits some potential anticancer activity as well, downregulating expression of the progesterone receptor, estrogen receptor, and p-Src, inhibiting growth of uterine leiomyoma cells.

Product Info

Cas No.

16320-04-0

Purity

≥98%

Formula

C21H24O2

Formula Wt.

308.41

Chemical Name

(17a)-13-Ethyl-17-hydroxy-18,19-dinorpregna-4,9,11-trien-20-yn-3-one

IUPAC Name

(8S,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,14,15, 16-octahydrocyclopenta[a]phenanthren-3-one

Synonym

13b-ethyl-17a-ethynyl-17b-hydroxy-4,9,11-gonatrien-3-one, 13b-ethyl-17a-ethynyl-D4,9,11-gonatriene-17b-ol-3-one, ethylnorgestrienone

Melting Point

154°C

Appearance

Yellowish crystalline powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

G1975 MSDS PDF

Info Sheet

G1975 Info Sheet PDF

References

Zhu Y, Zhang T, Xie S, et al. Gestrinone inhibits growth of human uterine leiomyoma may relate to activity regulation of ERα, Src and P38 MAPK. Biomed Pharmacother. 2012 Dec;66(8):569-77. PMID: 23102719.

Wu S, Dong J, Cong J, et al. Gestrinone compared with mifepristone for emergency contraception: a randomized controlled trial. Obstet Gynecol. 2010 Apr;115(4):740-4. PMID: 20308833.

Ohno Y, Kitagawa I, Tamura H, et al. Antiestrogenic effect of gestrinone as an inhibitor of [3H]-estradiol binding to nuclear type II sites. Gynecol Obstet Invest. 1991;31(2):97-101. PMID: 2037266.

Venturini PL, Bertolini S, Brunenghi MC, et al. Endocrine, metabolic, and clinical effects of gestrinone in women with endometriosis. Fertil Steril. 1989 Oct;52(4):589-95. PMID: 2806598.

Tamaya T, Fujimoto J, Watanabe Y, et al. Gestrinone (R2323) binding to steroid receptors in human uterine endometrial cytosol. Acta Obstet Gynecol Scand. 1986;65(5):439-41. PMID: 3490730.

Kauppila A, Isomaa V, Rönnberg L, et al. Effect of gestrinone in endometriosis tissue and endometrium. Fertil Steril. 1985 Oct;44(4):466-70. PMID: 2996949.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • G3357

    Ginkgolide C

    Diterpene lactone found in Ginkgo; GABA-A, α-1...

    ≥98%
  • D1761

    15-Acetyl-deoxynivalenol

    Type A trichothecene mycotoxin produced by Fusa...

    ≥98%, TLC
  • Z5745

    Zolmitriptan

    5-HT1B/1D agonist.

    ≥99%
  • V0147

    Valproic Acid Sodium

    T-type Ca2+ and voltage-gated Na+ channel block...

    ≥98%
  • D5611

    Docosahexaenoic Acid (all cis-4,7,10,13,16,19) Methyl Ester

    Essential fatty acid found in fish oil, involve...

    ≥99%
  • N0068

    Naringenin

    Flavanone found in species of Citrus. Naringen...

    ≥98%
  • M0009

    Macitentan

    ET-A/B antagonist.

    ≥99%
  • M1626

    Megestrol Acetate

    Synthetic progestogen, orexigenic.

    ≥98%
  • F4781

    Fludarabine

    Nucleoside (adenosine) analog; DNA chain termin...

    ≥98%
  • A4402

    L-Alaninol

    Amino acid alcohol.

    ≥98%
  • R1217

    RDEA119

    MEK1/2 inhibitor.

    ≥98%
  • A5276

    Angiotensin I, human

    Endogenous peptide, cleavage product of angiote...

    ≥98%
  • B011458

    Baloxavir

    Cap-dependent endonuclease inhibitor

    ≥ 99%
  • P2816

    S-(N-3-Phenylpropylthiocarbamoyl)-L-cysteine

    Cysteine-ITC conjugate.

    ≥98%
  • A464768

    Altertoxin 1

    Mycotoxin contaminant in food and feed.

    ≥97%
  • F3208

    Fibrinopeptide B, human

    Antimicrobial peptide, generated during fibrin ...

    ≥95%
  • G5216

    GNE-7915

    LRRK2 inhibitor.

    ≥98%
  • R3012

    Recombinant TpN 17 protein

    Recombinant protein containing Treponema pallid...

    ≥95%
  • C1668

    Cerivastatin Sodium

    Statin; HMG-CoA reductase inhibitor.

    ≥98%
  • Z1602

    Zearalenone

    Mycotoxin produced by Fusarium; ER agonist.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only