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Ginsenoside Rb2

Ginsenoside Rb2

Product ID G3553
Cas No. 11021-13-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $118.40 In stock
5 mg $408.30 In stock
10 mg $612.70 In stock
25 mg $1,225.20 In stock
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  • Product Info
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  • References
  • Description
  • Product Info
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Description

Ginsenoside Rb2 is a triterpene saponin originally found in species of Panax (ginseng) that exhibits anti-osteoporotic, antioxidative, antiviral, anti-hyperlipidemic, anti-metastatic, anti-angiogenic, and anticancer chemotherapeutic activities. In vivo, ginsenoside Rb2 decreases levels of malondialdehyde and increases levels of glutathione, improving bone microarchitecture and bone mineral density. In other animal models, this compound decreases virus titers and protects against infection of hemagglutinating virus of Japan. In adipocytes, ginsenoside Rb2 decreases levels of cholesterol and triglycerides and increases expression of SREBP. In uterine endometrial cancer cells, ginsenoside Rb2 decrease expression of matrix metalloproteinase 2 (MMP2), suppressive cellular invasion; this compound also inhibits neovascularization and tumor growth in animal models of melanoma.

Product Info

Cas No.

11021-13-9

Purity

≥98%

Formula

C53H90O22

Formula Wt.

1079.27

IUPAC Name

(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4, 5-dihydroxy-6-(hydroxymethyl)-2-[[(3S,5R,8R,9R,10R,12R,13R,14R, 17S)-12-hydroxy-4,4,8,10,14-pentamethyl-17-[(2S)-6-methyl-2-[(2S,3R,5S, 6R)-3,4,5-trihydroxy-6-[[(2S,3R,4S,5S)-3,4, 5-trihydroxyoxan-2-yl]oxymethyl]oxan-2-yl]oxyhept-5-en-2-yl]-2,3,5,6,7, 9,11,12,13,15,16, 17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]oxan-3-yl]oxy-6- (hydroxymethyl)oxane-3,4,5-triol

Synonym

Ginsenoside C

Melting Point

197-199°C

Solubility

Soluble in water.

Appearance

White Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

G3553 MSDS PDF

Info Sheet

G3553 Info Sheet PDF

References

Huang Q, Gao B, Jie Q, et al. Ginsenoside-Rb2 displays anti-osteoporosis effects through reducing oxidative damage and bone-resorbing cytokines during osteogenesis. Bone. 2014 Jun 13. [Epub ahead of print]. PMID: 24933344.

Yoo YC, Lee J, Park SR, et al. Protective effect of ginsenoside-Rb2 from Korean red ginseng on the lethal infection of haemagglutinating virus of Japan in mice. J Ginseng Res. 2013 Mar;37(1):80-6. PMID: 23717160.

Kim EJ, Lee HI, Chung KJ, et al. The ginsenoside-Rb2 lowers cholesterol and triacylglycerol levels in 3T3-L1 adipocytes cultured under high cholesterol or fatty acids conditions. BMB Rep. 2009 Apr 30;42(4):194-9. PMID: 19403041.

Fujimoto J, Sakaguchi H, Aoki I, et al. Inhibitory effect of ginsenoside-Rb2 on invasiveness of uterine endometrial cancer cells to the basement membrane. Eur J Gynaecol Oncol. 2001;22(5):339-41. PMID: 11766734.

Sato K, Mochizuki M, Saiki I, et al. Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng, ginsenoside-Rb2. Biol Pharm Bull. 1994 May;17(5):635-9. PMID: 7522731.

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