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Givinostat Hydrochloride

Givinostat Hydrochloride

Product ID G346851
Cas No. 199657-29-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $88.60 In stock
5 mg $265.90 In stock
25 mg $988.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Givinostat is a non-selective histone deacetylase (HDAC) inhibitor. It exhibits antiproliferative and apoptosis inducing activity in urothelial carcinoma cells with distinct HDAC1 and 2 expression profiles. Givinostat also inhibits proliferation and induces apoptosis in some difficult to treat subsets of acute lymphocyctic leukemia (ALL), like those carrying CRLF2 rearrangements. This is possibly due to inhibition of the JAK/STAT pathway.

Product Info

Cas No.

199657-29-9

Purity

≥98%

Formula

C24H27N3O4 • HCl

Formula Wt.

457.96

IUPAC Name

{6-[(Diethylamino)methyl]-2-naphthyl}methyl [4-(hydroxycarbamoyl)phenyl]carbamate

Synonym

ITF-2357 Hydrochloride

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G346851 MSDS PDF

Info Sheet

G346851 Info Sheet PDF

References

Pinkerneil M., Hoffmann M., et al. Inhibition of Class I Histone Deacetylases 1 and 2 Promotes Urothelial Carcinoma Cell Death by Various Mechanisms. Mol Cancer Ther. 15(2):299-312 (2016). PMID: 26772204.

Savino A., Samo J., et al. The histone deacetylase inhibitor givinostat (ITF2357) exhibits potent anti-tumor activity against CRLF2-rearranged BCP-ALL. Leukemia. 31(11):2365-75 (2017). PMID: 28331226.

Custom Order

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