• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Givinostat Hydrochloride

Givinostat Hydrochloride

Product ID G346851
Cas No. 199657-29-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $88.60 In stock
5 mg $265.90 In stock
25 mg $988.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Givinostat is a non-selective histone deacetylase (HDAC) inhibitor. It exhibits antiproliferative and apoptosis inducing activity in urothelial carcinoma cells with distinct HDAC1 and 2 expression profiles. Givinostat also inhibits proliferation and induces apoptosis in some difficult to treat subsets of acute lymphocyctic leukemia (ALL), like those carrying CRLF2 rearrangements. This is possibly due to inhibition of the JAK/STAT pathway.

Product Info

Cas No.

199657-29-9

Purity

≥98%

Formula

C24H27N3O4 • HCl

Formula Wt.

457.96

IUPAC Name

{6-[(Diethylamino)methyl]-2-naphthyl}methyl [4-(hydroxycarbamoyl)phenyl]carbamate

Synonym

ITF-2357 Hydrochloride

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G346851 MSDS PDF

Info Sheet

G346851 Info Sheet PDF

References

Pinkerneil M., Hoffmann M., et al. Inhibition of Class I Histone Deacetylases 1 and 2 Promotes Urothelial Carcinoma Cell Death by Various Mechanisms. Mol Cancer Ther. 15(2):299-312 (2016). PMID: 26772204.

Savino A., Samo J., et al. The histone deacetylase inhibitor givinostat (ITF2357) exhibits potent anti-tumor activity against CRLF2-rearranged BCP-ALL. Leukemia. 31(11):2365-75 (2017). PMID: 28331226.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • D3357

    Diosmin

    Flavone found in Teucrium.

    ≥95%
  • L8008

    D-Luciferin, firefly, Free Acid

    Heterocyclic light-emitting compound, natural l...

    ≥98%
  • D509921

    DMXAA

    Mouse selective STING agonist.

    ≥99%
  • G0245

    Gallocatechin Gallate

    Polyphenol found in Camilla sinensis; HIV integ...

    ≥98%
  • S0930

    Schisantherin A

    Dibenzocyclooctadiene found in Schisandra.

    ≥98%
  • R5894

    Roxatidine Acetate Hydrochloride

    Histamine H2 antagonist.

    ≥98%
  • B3272

    Bis(3,5-dibromosalicyl) Fumarate

    Aspirin analog; hemoglobin chain cross-linker.<...

    ≥91%
  • G0146

    Galanin, human

    Endogenous neuropeptide, involved in nociceptio...

    ≥98%
  • D0032

    Daidzein

    Phytoestrogen, isoflavone found in various plan...

    ≥97%
  • A8812

    AWD 131-138

    GABA-A positive modulator.

    ≥99%
  • T0298

    Tazobactam

    β-lactamase inhibitor.

    ≥98%
  • L9701

    LY-450139

    GHS-R1a agonist, γ-secretase inhibitor.

    ≥98%
  • D0010

    3H-1,2-Dithiole-3-thione

    Induces activation of Nrf2; inhibits apoptosis ...

    ≥98%
  • E622698

    Eprosartan Mesylate

    Nonpeptide angiotensin II receptor antagonist

    ≥99%
  • G7440

    GSK-1120212

    MEK1/2 inhibitor.

    ≥98%
  • R5700

    Ro 61-8048

    Kynurenine 3-hydroxylase inhibitor.

    ≥99%
  • C691325

    Cridanimod

    STING agonist

    ≥99%
  • N1986

    Neuropeptide Y, human/rat

    Endogenous peptide neurotransmitter, involved i...

    ≥95%
  • M577521

    Monascorubrin

    Bulgarialactone azaphilone

    ≥98%
  • A5170

    Amrinone

    Pyridine; PDE3 inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only