• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Glimepiride

Glimepiride

Product ID G4535
Cas No. 93479-97-1
Purity ≥98%
Product Unit SizeCostQuantityStock
500 mg $86.80 In stock
1 g $139.00 In stock
5 g $572.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Glimepiride is a second generation sulfonylurea that exhibits anti-diabetic activity. Glimepiride inhibits ATP-dependent K+ channels in β cells, forcing cells to remain depolarized, increasing Ca2+ influx and insulin secretion. Glimepiride also exhibits neuroprotective benefit, decreasing expression and activity of BACE1 and amyloid-β (Aβ) in neurons in a PPARγ-dependent manner.

Product Info

Cas No.

93479-97-1

Purity

≥98%

Formula

C24H34N4O5S

Formula Wt.

490.62

Chemical Name

3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans-4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide

IUPAC Name

4-ethyl-3-methyl-N-[2-[4-[(4-methylcyclohexyl)carbamoylsulfamoyl]phenyl] ethyl]-5-oxo-2H-pyrrole-1-carboxamide

Synonym

HOE-490, Amarel

Melting Point

212-215°C

Solubility

Soluble in DMSO (25mg/mL).

Appearance

White or almost white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

G4535 MSDS PDF

Info Sheet

G4535 Info Sheet PDF

References

Sobky S, Fawzy I, Ahmed M, et al. Drug repurposing of argatroban, glimepiride, and ranolazine shows anti-SARS-CoV-2 activity via diverse mechanisms. Heliyon. 2025 Jan 10;11(3):e41894. PMID: 39968139.

Liu F, Wang Y, Yan M, et al. Glimepiride attenuates Aβ production via suppressing BACE1 activity in cortical neurons. Neurosci Lett. 2013 Dec 17;557 Pt B:90-4. PMID: 24184877.

Bashir MI, Pathan MF, Raza SA, et al. Role of oral hypoglycemic agents in the management of type 2 diabetes mellitus during Ramadan. Indian J Endocrinol Metab. 2012 Jul;16(4):503-7. PMID: 22837904.

Abdelmoneim AS, Hasenbank SE, Seubert JM, et al. Variations in tissue selectivity amongst insulin secretagogues: a systematic review. Diabetes Obes Metab. 2012 Feb;14(2):130-8. PMID: 21923736.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • E6880

    Erucin

    Isothiocyanate found in cruciferous vegetables,...

    ≥98%
  • R1860

    Repaglinide

    Sulfonylurea; ATP-sensitive K+ channel blocker....

    ≥98%
  • A7461

    Asperosaponin VI

    Triterpene saponin found in Dipsacus asper.

    ≥98%
  • V720004

    VS-4718

    Focal adhesion kinase (FAK) inhibitor.

    ≥99%
  • V344761

    Vitamin K2

    2-methyl-1,4-naphthoquinone derivative

    ≥98%
  • E6256

    Epothilone A

    Microtubule depolymerization inhibitor.

    ≥95%
  • A9712

    AZD-6482

    p110β PI3K inhibitor.

    ≥98%
  • T0077

    Transactivator of Transcription Peptide (2-4)

    Peptide, contains two cell-penetrating sequence...

    ≥95%
  • C0247

    Calcineurin Autoinhibitory Peptide

    Peptide; calcineurin inhibitor.

    ≥95%
  • I7155

    Isoindigo

    Potential AhR binding agent.

    ≥98%
  • T7032

    Triamcinolone

    Synthetic steroid; glucocorticoid agonist.

    ≥98%
  • E6356

    Epothilone D

    Microtubule depolymerization inhibitor.

    ≥98%
  • F3205

    Fibrinogen γ-chain Dodecapeptide

    Platelet substitute, peptide; GP IIb/IIIa activ...

    ≥95%
  • E6235

    Epirubicin Hydrochloride

    Anthracycline, DNA intercalator; topoisomerase ...

    ≥90%
  • T2816

    L-Theanine

    Non-essential amino acid found in Camellia and ...

    ≥98%
  • V0352

    Vandetanib

    RET, EGFR, VEGFR2 inhibitor.

    ≥98%
  • O9257

    16-Oxokahweol

    Synthetic kahweol derivative.

    ≥95%
  • A4933

    Amifostine Trihydrate

    Thiol prodrug, antioxidant.

    ≥98%
  • G4480

    Glucagon, human

    Endogenous peptide hormone, counteracts insulin...

    ≥95%
  • B6998

    Bryostatin 1

    Macrolide lactone found in Bugula; TLR4 activat...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only