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Glipizide is a second generation sulfonylurea that exhibits anti-diabetic activity. Glipizide inhibits ATP-dependent K+ channels in β cells, forcing cells to remain depolarized, increasing Ca2+ influx and insulin secretion. Glipizide also decreases the metabolic clearance rate of insulin.
| Cas No. | 29094-61-9 |
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| Purity | ≥98% |
| Formula | C21H27N5O4S |
| Formula Wt. | 445.54 |
| Chemical Name | N-[2-[4-[[[(Cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl-5-methylpyrazinecarboxamide |
| IUPAC Name | N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-5-methylpyrazine-2- carboxamide |
| Synonym | Glibenese, Blucotrol, Minidiab, Ozidia |
| Melting Point | 208-209°C |
| Solubility | Soluble in DMSO (48mg/mL) or methanol (1.9mg/mL).. |
| Appearance | White or Almost White Crystalline Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Barzilai N, Groop PH, Groop L, et al. A novel mechanism of glipizide sulfonylurea action: decreased metabolic clearance rate of insulin. Acta Diabetol. 1995 Dec;32(4):273-8. PMID: 8750768.
Weinhaus AJ, Poronnik P, Cook DI, et al. Insulin secretagogues, but not glucose, stimulate an increase in [Ca2+]i in the fetal rat beta-cell. Diabetes. 1995 Jan;44(1):118-24. PMID: 7529202.
Heurteaux C, Bertaina V, Widmann C, et al. K+ channel openers prevent global ischemia-induced expression of c-fos, c-jun, heat shock protein, and amyloid beta-protein precursor genes and neuronal death in rat hippocampus. Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9431-5. PMID: 8415718.