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Glipizide

Glipizide

Product ID G4634
Cas No. 29094-61-9
Purity ≥98%
Product Unit SizeCostQuantityStock
500 mg $71.50 In stock
1 g $122.70 In stock
5 g $357.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Glipizide is a second generation sulfonylurea that exhibits anti-diabetic activity. Glipizide inhibits ATP-dependent K+ channels in β cells, forcing cells to remain depolarized, increasing Ca2+ influx and insulin secretion. Glipizide also decreases the metabolic clearance rate of insulin.

Product Info

Cas No.

29094-61-9

Purity

≥98%

Formula

C21H27N5O4S

Formula Wt.

445.54

Chemical Name

N-[2-[4-[[[(Cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl-5-methylpyrazinecarboxamide

IUPAC Name

N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-5-methylpyrazine-2- carboxamide

Synonym

Glibenese, Blucotrol, Minidiab, Ozidia  

Melting Point

208-209°C

Solubility

Soluble in DMSO (48mg/mL) or methanol (1.9mg/mL)..

Appearance

White or Almost White Crystalline Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

G4634 MSDS PDF

Info Sheet

G4634 Info Sheet PDF

References

Barzilai N, Groop PH, Groop L, et al. A novel mechanism of glipizide sulfonylurea action: decreased metabolic clearance rate of insulin. Acta Diabetol. 1995 Dec;32(4):273-8. PMID: 8750768.

Weinhaus AJ, Poronnik P, Cook DI, et al. Insulin secretagogues, but not glucose, stimulate an increase in [Ca2+]i in the fetal rat beta-cell. Diabetes. 1995 Jan;44(1):118-24. PMID: 7529202.

Heurteaux C, Bertaina V, Widmann C, et al. K+ channel openers prevent global ischemia-induced expression of c-fos, c-jun, heat shock protein, and amyloid beta-protein precursor genes and neuronal death in rat hippocampus. Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9431-5. PMID: 8415718.

Custom Order

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