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GNF-2

GNF-2

Product ID G5320
Cas No. 778270-11-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $112.60 In stock
5 mg $202.90 In stock
25 mg $601.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

GNF-2 is an inhibitor of Abl kinase that exhibits anticancer chemotherapeutic, anti-resorptive, and anti-osteoporotic activities. GNF-2 shows potential benefit in the treatment of Philadelphia chromosome-positive acute myelogenous leukemia (ALL). In vitro, GNF-2 inhibits differentiation of osteoclasts, activity of NF-κB, and induction of c-Fos and NFATc1, resulting in caspase-mediated apoptosis. GNF-2 also inhibits resorption of mature osteoclasts and prevents phagocytosis in bone marrow-derived macrophages. In vivo, this compound decreases osteoclast numbers and prevents bone loss.

Product Info

Cas No.

778270-11-4

Purity

≥98%

Formula

C18H13F3N4O2

Formula Wt.

374.32

IUPAC Name

3-[6-[4-(trifluoromethoxy)anilino]pyrimidin-4-yl]benzamide

Solubility

DMSO 74 mg/mL (197.69 mM) Water Insoluble Ethanol Insoluble

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

G5320 MSDS PDF

Info Sheet

G5320 Info Sheet PDF

References

Kim HJ, Yoon HJ, Choi JY, et al. The tyrosine kinase inhibitor GNF-2 suppresses osteoclast formation and activity. J Leukoc Biol. 2014 Feb;95(2):337-45. PMID: 24130113.

Greuber EK, Pendergast AM. Abl family kinases regulate FcγR-mediated phagocytosis in murine macrophages. J Immunol. 2012 Dec 1;189(11):5382-92. PMID: 23100514.

Mian AA, Metodieva A, Najajreh Y, et al. p185(BCR/ABL) has a lower sensitivity than p210(BCR/ABL) to the allosteric inhibitor GNF-2 in Philadelphia chromosome-positive acute lymphatic leukemia. Haematologica. 2012 Feb;97(2):251-7. PMID: 22058195.

Deng X, Okram B, Ding Q, et al. Expanding the diversity of allosteric bcr-abl inhibitors. J Med Chem. 2010 Oct 14;53(19):6934-46. PMID: 20828158.

Adrián FJ, Ding Q, Sim T, et al. Allosteric inhibitors of Bcr-abl-dependent cell proliferation. Nat Chem Biol. 2006 Feb;2(2):95-102. PMID: 16415863.

Custom Order

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