• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Gossypol Acetic Acid

Gossypol Acetic Acid

Product ID G5875
Cas No. 12542-36-8
Purity ≥98%
Product Unit SizeCostQuantityStock
250 mg $110.30 In stock
1 g $325.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Gossypol acetic acid (GA) exhibits anticancer chemotherapeutic, pro-oxidative, antioxidative, and antibacterial activities. GA inhibits Bcl-2/Bcl-xl, enhancing TRAIL/mitochondria-induced apoptosis in breast cancer cells. In animal models, GA delayed the onset of androgen-independent prostate cancer. In macrophages, GA increases production of ROS, upregulates expression of caspases 3 and 9, and decreases the mitochondrial membrane potential, inducing apoptosis. GA increases activity of glutathione peroxidase and inhibits lipid peroxidation but also increases generation of ROS and induces DNA damage. This compound also exhibits antibiotic activity, inhibiting growth of gram negative bacteria such as Edwardsiella. Additionally, GA has been studied as a male contraceptive; it inhibits sialyl transferase activity in seminal plasma, decreases tubulin content and spermatocyte mobility, and reversibly inhibits spermatogenesis in vivo.

Product Info

Cas No.

12542-36-8

Purity

≥98%

Formula

C30H30O8 • C2H4O2

Formula Wt.

578.61

Chemical Name

1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1- methylethyl)[2,2'-binaphthalene]-8,8'-dicarboxaldehyde-acetic acid

IUPAC Name

acetic acid;7-(8-formyl-1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)-2,3,8-trihydroxy-6-methyl-4-propan-2-ylnaphthalene-1-carbaldehyde

Synonym

Gossypol acetate

Melting Point

184

Solubility

Soluble in DMSO, methanol or ethanol. Insoluble in water.

Appearance

Yellow Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

G5875 MSDS PDF

Info Sheet

G5875 Info Sheet PDF

References

Deng S, Yuan H, Yi J, et al. Gossypol acetic acid induces apoptosis in RAW264.7 cells via a caspase-dependent mitochondrial signaling pathway. J Vet Sci. 2013;14(3):281-9. PMID: 23820203.

Hall C, Troutman SM, Price DK, et al. Bcl-2 family of proteins as therapeutic targets in genitourinary neoplasms. Clin Genitourin Cancer. 2013 Mar;11(1):10-9. PMID: 23083798.

Kisim A, Atmaca H, Cakar B, et al. Pretreatment with AT-101 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of breast cancer cells by inducing death receptors 4 and 5 protein levels. J Cancer Res Clin Oncol. 2012 Jul;138(7):1155-63. PMID: 22411600.

El-Sharaky AS, Wahby MM, Bader El-Dein MM, et al. Mutual anti-oxidative effect of gossypol acetic acid and gossypol-iron complex on hepatic lipid peroxidation in male rats. Food Chem Toxicol. 2009 Nov;47(11):2735-41. PMID: 19665044.

Loberg RD, McGregor N, Ying C, et al. In vivo evaluation of AT-101 (R-(-)-gossypol acetic acid) in androgen-independent growth of VCaP prostate cancer cells in combination with surgical castration. Neoplasia. 2007 Dec;9(12):1030-7. PMID: 18084610.

Yildirim-Aksoy M, Lim C, Dowd MK, et al. In vitro inhibitory effect of gossypol from gossypol-acetic acid, and (+)- and (-)-isomers of gossypol on the growth of Edwardsiella ictaluri. J Appl Microbiol. 2004;97(1):87-92. PMID: 15186445.

Sharma S, Kumar M, Goyal RB, et al. Reversible antispermatogenic effect of gossypol in langur monkeys (Presbytis entellus entellus). Adv Contracept. 1999;15(1):15-27. PMID: 10794043.

Teng CS. Reversible changes in the content of cellular and microtubular tubulin in spermatogenic cells after gossypol treatment. Contraception. 1997 Jan;55(1):41-6. PMID: 9013060.

Levinsky H, Singer R, Sagiv M, et al. Inhibition of sialyl transferase activity by gossypol acetic acid in human seminal plasma. Andrologia. 1991 Mar-Apr;23(2):159-61. PMID: 1952122.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C0396

    CAY10505

    p110γ PI3K inhibitor.

    ≥98%
  • P1765

    Peptide Standard 1

    For use in amino acid analysis.

    ≥95%
  • T0216

    TAE-226

    FAK inhibitor.

    ≥98%
  • F5870

    N-formyl-Met-Leu-Phe

    Peptide, involved in neutrophil activation; FPR...

    ≥95%
  • L8377

    Luteolin

    Flavonoid found in various plant sources; DAT a...

    ≥95%
  • S8151

    Sumatriptan Succinate

    Tryptamine; 5-HT1B/1D agonist, TRPV1 antagonist...

    ≥99%
  • D1859

    2-Deoxy-D-glucose

    Glucose metabolism inhibitor, N-linked glycosyl...

    ≥99%
  • N5986

    Novobiocin Sodium

    Aminocoumarin; bacterial DNA gyrase inhibitor.<...

    ≥98%
  • D3229

    7,8-Dihydrokawain

    Kavalactone originally found in Piper methystic...

    ≥98%
  • N1984

    Neuropeptide FF

    Endogenous RF-amide peptide, involved in nocice...

    ≥95%
  • H9763

    Hypoxanthine

    Endogenous purine derivative of xanthine.

    ≥98%
  • G0152

    Ganciclovir

    Nucleoside (guanosine) analog; DNA chain termin...

    ≥98%
  • C0170

    N-(4-Carbethoxyphenyl)retinamide

    Retinoid, differentiation inducer.

    ≥98%
  • V1872

    Vesicular Stomatitis Virus Peptide

    Peptide fragment of VSV; LDLR agonist.

    ≥95%
  • G1652

    Genistein

    Phytoestrogen, isoflavone found in various plan...

    ≥98%
  • A985128

    AZD-7648

    DNA-PK inhibitor.

    ≥98%
  • I4802

    Imatinib Mesylate

    Abl, c-Kit, PDGFR inhibitor.

    ≥98%
  • E6814

    Erdosteine

    Thiol derivative, antioxidant.

    ≥98%
  • N0075

    Natamycin

    Polyene macrolide; ergosterol inhibitor.

    ≥98%
  • A0802

    Acarbose

    α-glucosidase inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only