Description
GSK-2334470 is a selective inhibitor of PDK1 that exhibits anticancer activity in in vitro models. GSK-2334470 inhibits T-loop phosphorylation of SGK and S6K1, Akt and Akt substrates GSK3, FoxO, and PRAS40, and ERK substrate RSK2.
Product Unit Size | Cost | Quantity | Stock |
---|
GSK-2334470 is a selective inhibitor of PDK1 that exhibits anticancer activity in in vitro models. GSK-2334470 inhibits T-loop phosphorylation of SGK and S6K1, Akt and Akt substrates GSK3, FoxO, and PRAS40, and ERK substrate RSK2.
Cas No. | 1227911-45-6 |
---|---|
Purity | ≥99%, ≥99%ee |
Formula | C25H34N8O |
Formula Wt. | 462.59 |
Chemical Name | (3S,6R)-1-[6-(3-amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl]-N-cyclohexyl-6-methylpiperidine-3-carboxamide |
IUPAC Name | (3S,6R)-1-[6-(3-amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl]-N- cyclohexyl-6-methylpiperidine-3-carboxamide |
Solubility | DMSO 28 mg/mL (64.6 mM) Water Insoluble Ethanol Insoluble |
Appearance | off-white powder |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Najafov A, Sommer EM, Axten JM, et al. Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1. Biochem J. 2011 Jan 15;433(2):357-69. PMID: 21087210.
Adenosine A2A antagonist.
MEK1/2 inhibitor.
Piperazine; FIASMA, D2 antagonist, hERG K+ chan...
FGFR inhibitor.
H+/K+ ATPase and ROCK-2 inhibitor.
Diterpene found in Anisomeles.
Peptide, substance P analog; NK agonist.
Penicillin derivative, chelating agent; carboxy...
Vitamin A metabolite, differentiation inducer; ...
NSAID; COX-1/2 inhibitor, potential K+ channel ...
Triterpene aglycone originally found in Centell...
Diterpene found in Salvia.
Arp2/3 inhibitor.
Synthetic derivative of 6-methylsulfinyl-hexane...
KRAS inhibitor
Peptide; fibrinolysis inhibitor.
GABA-A antagonist.
Glycosaminoglycan
GHB agonist, D2/3 antagonist.
Cholesterol ester transfer protein inhibitor.