Description
GSK-2334470 is a selective inhibitor of PDK1 that exhibits anticancer activity in in vitro models. GSK-2334470 inhibits T-loop phosphorylation of SGK and S6K1, Akt and Akt substrates GSK3, FoxO, and PRAS40, and ERK substrate RSK2.
Product Unit Size | Cost | Quantity | Stock |
---|
GSK-2334470 is a selective inhibitor of PDK1 that exhibits anticancer activity in in vitro models. GSK-2334470 inhibits T-loop phosphorylation of SGK and S6K1, Akt and Akt substrates GSK3, FoxO, and PRAS40, and ERK substrate RSK2.
Cas No. | 1227911-45-6 |
---|---|
Purity | ≥99%, ≥99%ee |
Formula | C25H34N8O |
Formula Wt. | 462.59 |
Chemical Name | (3S,6R)-1-[6-(3-amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl]-N-cyclohexyl-6-methylpiperidine-3-carboxamide |
IUPAC Name | (3S,6R)-1-[6-(3-amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl]-N- cyclohexyl-6-methylpiperidine-3-carboxamide |
Solubility | DMSO 28 mg/mL (64.6 mM) Water Insoluble Ethanol Insoluble |
Appearance | off-white powder |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Najafov A, Sommer EM, Axten JM, et al. Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1. Biochem J. 2011 Jan 15;433(2):357-69. PMID: 21087210.
Macrocyclic lactone.
Aromatase inhibitor.
Mycotoxin, metabolite of aflatoxin B1 produced ...
Inhibitor of FAK and ALK.
NSAID; COX-2 inhibitor.
Endogenous peptide hormone, involved in cell gr...
Inhibitor of PTEFb/CDK9.
Fermentation impurity
Purine derivative; CDK inhibitor.
RT inhibitor.
PKA inhibitor, potential ROCK, S6K1, MSK1, PKB ...
Phenylpropene derivative found in essential oil...
β2-adrenergic agonist.
Insecticide; α-adrenergic agonist, MAO inhibit...
MEK1/2 inhibitor.
Tropane alkaloid found in Solanaceae plants; α...
Alkaloid found in Securinega; potential GABA-A ...
ATP competitive CDK inhibitor.
Non-depolarizing NMJ blocker; nAChR antagonist....
SERM, androgen modulator.