Description
GSK-2334470 is a selective inhibitor of PDK1 that exhibits anticancer activity in in vitro models. GSK-2334470 inhibits T-loop phosphorylation of SGK and S6K1, Akt and Akt substrates GSK3, FoxO, and PRAS40, and ERK substrate RSK2.
GSK-2334470
Product ID G7344
Cas No. 1227911-45-6
Purity ≥99%, ≥99%ee
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Product Info
| Cas No. | 1227911-45-6 |
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| Purity | ≥99%, ≥99%ee |
| Formula | C25H34N8O |
| Formula Wt. | 462.59 |
| Chemical Name | (3S,6R)-1-[6-(3-amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl]-N-cyclohexyl-6-methylpiperidine-3-carboxamide |
| IUPAC Name | (3S,6R)-1-[6-(3-amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl]-N- cyclohexyl-6-methylpiperidine-3-carboxamide |
| Solubility | DMSO 28 mg/mL (64.6 mM) Water Insoluble Ethanol Insoluble |
| Appearance | off-white powder |
Shipping and Storage
| Store Temp | -20°C |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Najafov A, Sommer EM, Axten JM, et al. Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1. Biochem J. 2011 Jan 15;433(2):357-69. PMID: 21087210.