• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Guggulsterone

Guggulsterone

Product ID G8225
Cas No. 95975-55-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $157.50 In stock
25 mg $631.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Guggulsterone is a plant steroid obtained from myrrh that exhibits a wide variety of beneficial properties, including anti-metastatic, anticancer, anti-angiogenic, anti-fibrotic, antioxidative, anti-inflammatory, and anti-hyperlipidemic activities. In vitro, guggulsterone increases activation of caspase 3, decreases expression of matrix metalloproteinase 9 (MMP9), cyclin D1, Bcl-2, xlAP, and mucin MUC4, inhibits FAK, Src, and JAK/STAT signaling, and disrupts cytoskeletal organization; together, this results in apoptosis and inhibition of growth and colony formation of pancreatic cancer cells. In colon cancer cells, this compound inhibits expression of VEGF, ARNT, and STAT3 and decreases activity of matrix metalloproteinases 2 and 9 (MMP2/9), inducing apoptosis. Guggulsterone also increases apoptosis in hepatic stellate cells through inhibition of NF-κB activation, suggesting potential benefit as a treatment for chronic liver disease. Guggulsterone also exhibits cardioprotective benefits, inhibiting doxorubicin-induced toxicity in cardiomyocytes; guggulsterone decreases activity of ROS, malondialdehyde, and caspase 3, and also reverses doxorubicin-induced changes in poly(ADP)-ribose polymerase (PARP) cleavage, caspase expression, Bcl-2/Bax ratio, and cytochrome c release. Additionally, guggulsterone increases heme oxygenase 1 (HO-1) expression and Nrf2 activity, potentially through modulation of phosphate and tensin homolog (PTEN), in vitro. In other cellular models, guggulsterone inhibits lipopolysaccharide-induced increases in COX-2 and TNF-α as well as decreases in IκB kinase-α. In cellular and animal models, guggulsterone inhibits preadipocyte differentiation and increases lipolysis of mature adipocytes. Guggulsterone also inhibits the farnesoid X receptor (FXR).

Product Info

Cas No.

95975-55-6

Purity

≥98%

Formula

C21H28O2

Formula Wt.

312.45

Chemical Name

(17E)-Pregna-4,17(20)-diene-3,16-dione, (17Z)-Pregna-4,17(20)-diene-3,16-dione

IUPAC Name

(8R,9S,10R,13S,14S,17E)-17-ethylidene-10,13-dimethyl-1,2,6,7,8,9,11,12, 14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione; (8R,9S,10R,13S,14S,17Z)-17-ethylidene-10,13-dimethyl-1,2,6,7,8,9,11,12, 14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione

Synonym

Pregna-4,17-diene-3,16-dione; E,Z-Guggulsterone.

Melting Point

194-195°C

Appearance

Off white to yellow powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

G8225 MSDS PDF

Info Sheet

G8225 Info Sheet PDF

References

Macha MA, Rachagani S, Gupta S, et al. Guggulsterone decreases proliferation and metastatic behavior of pancreatic cancer cells by modulating JAK/STAT and Src/FAK signaling. Cancer Lett. 2013 Dec 1;341(2):166-77. PMID: 23920124.

Kim BH, Yoon JH, Yang JI, et al. Guggulsterone attenuates activation and survival of hepatic stellate cell by inhibiting nuclear factor kappa B activation and inducing apoptosis. J Gastroenterol Hepatol. 2013 Dec;28(12):1859-68. PMID: 23808824.

Wang WC, Uen YH, Chang ML, et al. Protective effect of guggulsterone against cardiomyocyte injury induced by doxorubicin in vitro..BMC Complement Altern Med. 2012 Aug 27;12:138. PMID: 22920231.

Song JJ, Kwon SK, Cho CG, et al Guggulsterone suppresses LPS induced inflammation of human middle ear epithelial cells (HMEEC). Int J Pediatr Otorhinolaryngol. 2010 Dec;74(12):1384-7. PMID: 20971513.

Kim ES, Hong SY, Lee HK, et al. Guggulsterone inhibits angiogenesis by blocking STAT3 and VEGF expression in colon cancer cells. Oncol Rep. 2008 Dec;20(6):1321-7. PMID: 19020709.

Ahn KS, Sethi G, Sung B, et al. Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1. Cancer Res. 2008 Jun 1;68(11):4406-15. PMID: 18519703.

Yang JY, Della-Fera MA, Baile CA. Guggulsterone inhibits adipocyte differentiation and induces apoptosis in 3T3-L1 cells. Obesity (Silver Spring). 2008 Jan;16(1):16-22. PMID: 18223606.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • L4796

    LY-294002

    PI3K inhibitor.

    ≥99%
  • T5672

    Tosufloxacin Tosylate

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • A081014

    Acalabrutinib

    Inhibitor of Bruton’s tyrosine kinase (BTK).<...

    ≥99%
  • L3454

    Lincomycin Hydrochloride Monohydrate

    Lincosamide; peptidyl transferase inhibitor, pr...

    ≥98%
  • V1769

    Verapamil Hydrochloride

    L-type Ca2+ channel blocker.

    ≥98%
  • B1545

    Benzalkonium Bromide

    Quaternary ammonium cationic surfactant, dissoc...

    ≥95%
  • I527211

    Infigratinib Phosphate

    FGFR inhibitor.

    ≥98%
  • E6825

    Ergosterol

    Sterol cell membrane component found in yeast a...

    ≥96%
  • B1855

    O6-Benzylguanine

    MGMT inhibitor.

    ≥98%
  • E4668

    ELR-510444

    Microtubule polymerization inhibitor.

    ≥98%
  • P1753

    Penicillamine

    Penicillin derivative, chelating agent; carboxy...

    ≥97%
  • S0049

    Salmon Calcitonin Acetate

    Peptide, involved in feeding behavior and insul...

    ≥95%
  • S5753

    Somatostatin-28 (1-14)

    Endogenous neuropeptide hormone; somatostatin a...

    ≥95%
  • V0275

    [Arg8]-Vasotocin

    Peptide, oxytocin-vasopressin analog.

    ≥95%
  • P200600

    PF-06873600

    CDK2/4/6 inhibitor

    ≥98%
  • T3461

    Tiplaxtinin

    PAI-1 inhibitor.

    ≥98%
  • A5162

    Amprolium Hydrochloride

    Thiamine, coccidiostat; thiamine transporter in...

    ≥97%
  • D1643

    Delta Sleep Inducing Peptide

    Peptide; GABA potentiator, NMDA negative allost...

    ≥95%
  • L8377

    Luteolin

    Flavonoid found in various plant sources; DAT a...

    ≥95%
  • T7044

    Triamcinolone Acetonide Acetate

    Steroid; glucocorticoid agonist.

    ≥97%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only