LKT Labs

Biochemicals for Life Science Research

Histrelin Acetate

Histrelin Acetate

Product ID H3277
Cas No. 76712-82-8
Purity ≥95%
Bulk Quote

Quicklinks

Description

Histrelin is an anti-estrogen, anti-testosterone analog of gonadotropin-releasing hormone (GnRH) or luteinizing hormone releasing hormone (LHRH). Histrelin binds and activates the GnRH/LHRH receptor, initially stimulating release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), but then inducing desensitization and decreasing levels of these hormones over long-term administration. Histrelin is clinically used to treat precocious puberty and to suppress estrogen and testosterone levels in prostate cancer patients.

Product Info

Cas No.

76712-82-8
Purity

≥95%
Formula

C66H86N18O12
Formula Wt.

1323.52
IUPAC Name

(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-3-(1-benzylimidazol-4-yl)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
Synonym

[des-Gly 10, D-His(Bzl) 6]-LH-RH ethylamide
Solubility

Soluble in DMSO.

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

H3277 MSDS PDF
Info Sheet

H3277 Info Sheet PDF

References

Lewis KA, Goldyn AK, West KW, et al. A single histrelin implant is effective for 2 years for treatment of central precocious puberty. J Pediatr. 2013 Oct;163(4):1214-6. PMID: 23809043.

Shore N, Cookson MS, Gittelman MC. Long-term efficacy and tolerability of once-yearly histrelin acetate subcutaneous implant in patients with advanced prostate cancer. BJU Int. 2012 Jan;109(2):226-32. PMID: 21851539.

Barradell LB, McTavish D. Histrelin. A review of its pharmacological properties and therapeutic role in central precocious puberty. Drugs. 1993 Apr;45(4):570-88. PMID: 7684676.

Gunnet JW, Demarest KT, Hahn DW, et al. Effects of a sustained release formulation of the gonadotrophin-releasing hormone agonist histrelin on serum concentrations of gonadotrophins and oestradiol, and ovarian LH/human chorionic gonadotrophin receptor content in the rat. J Endocrinol. 1991 Nov;131(2):211-8. PMID: 1744568.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • V0274

    [Lys8]-Vasopressin

    Peptide, vasopressin analog; V1/2 agonist.

    ≥95%
  • K7602

    KT5823

    PKG inhibitor.

    ≥98%
  • A5301

    Anacetrapib

    Cholesterol ester transfer protein inhibitor.

    ≥98%
  • N0163

    2-(1,8-Naphthyridin-2-yl)phenol

    Naphthalene; indirect STAT1 agonist.

    ≥98%
  • D509921

    DMXAA

    Mouse selective STING agonist.

    ≥99%
  • Z160021

    Zearalanone

    Mycotoxin.

    ≥97%
  • S1060

    Small Cardioactive Peptide A

    Peptide found in molluscs, cardiomodulator.

    ≥95%
  • E5568

    Enramycin A

    Polypeptide; peptidoglycan inhibitor.

    ≥95%
  • A4497

    Alyssin Sulfone

    Naturally sourced ITC, sulfonyl analog of sulfo...

    ≥97%
  • E6396

    EPZ005687

    EZH2 HMT inhibitor.

    ≥99%
  • E2003

    Efavirenz

    Non-nucleoside RT inhibitor.

    ≥99%
  • H1662

    HER2/neu (654-662) GP2

    Peptide fragment of HER2/neu/erbB2 receptor.

    ≥95%
  • B1977

    Betulin

    Pentacyclic triterpene found in various plant s...

    ≥98%
  • P2002

    PF-04691502 Dihydrate

    PI3K and mTOR inhibitor.

    ≥98%
  • T6933

    Trichostatin A

    HDAC inhibitor, mammalian RNA splicing modulato...

    ≥98%
  • I088240

    (S,S)-ICG-001

    Wnt/β-catenin inhibitor

    ≥98%
  • T6811

    Tranexamic Acid

    Plasminogen inhibitor.

    ≥98%
  • A6925

    L-Arginine Ethyl Ester Dihydrochloride

    Arginine source used to increase NO production....

    ≥98%
  • T286163

    Theaflavin-3,3’-digallate

    Polyphenolic compound present in black tea.

    ≥98%
  • T0393

    (+/-)-Taxifolin Hydrate

    Catechol-type flavonoid.

    ≥95%