• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Histrelin Acetate

Histrelin Acetate

Product ID H3277
Cas No. 76712-82-8
Purity ≥95%
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Histrelin is an anti-estrogen, anti-testosterone analog of gonadotropin-releasing hormone (GnRH) or luteinizing hormone releasing hormone (LHRH). Histrelin binds and activates the GnRH/LHRH receptor, initially stimulating release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), but then inducing desensitization and decreasing levels of these hormones over long-term administration. Histrelin is clinically used to treat precocious puberty and to suppress estrogen and testosterone levels in prostate cancer patients.

Product Info

Cas No.

76712-82-8

Purity

≥95%

Formula

C66H86N18O12

Formula Wt.

1323.52

IUPAC Name

(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-3-(1-benzylimidazol-4-yl)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide

Synonym

[des-Gly 10, D-His(Bzl) 6]-LH-RH ethylamide

Solubility

Soluble in DMSO.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

H3277 MSDS PDF

Info Sheet

H3277 Info Sheet PDF

References

Lewis KA, Goldyn AK, West KW, et al. A single histrelin implant is effective for 2 years for treatment of central precocious puberty. J Pediatr. 2013 Oct;163(4):1214-6. PMID: 23809043.

Shore N, Cookson MS, Gittelman MC. Long-term efficacy and tolerability of once-yearly histrelin acetate subcutaneous implant in patients with advanced prostate cancer. BJU Int. 2012 Jan;109(2):226-32. PMID: 21851539.

Barradell LB, McTavish D. Histrelin. A review of its pharmacological properties and therapeutic role in central precocious puberty. Drugs. 1993 Apr;45(4):570-88. PMID: 7684676.

Gunnet JW, Demarest KT, Hahn DW, et al. Effects of a sustained release formulation of the gonadotrophin-releasing hormone agonist histrelin on serum concentrations of gonadotrophins and oestradiol, and ovarian LH/human chorionic gonadotrophin receptor content in the rat. J Endocrinol. 1991 Nov;131(2):211-8. PMID: 1744568.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • Z4900

    ZM-447439 Trihydrate

    AurKA/B inhibitor.

    ≥99%
  • P0244

    Palbociclib Hydrochloride

    CDK4/6 inhibitor.

    ≥99%
  • G7442

    GSK-343

    EZH2 HMT inhibitor.

    ≥98%
  • I7457

    1-Isothiocyanato-6-(methylsulfinyl)-hexane

    Synthetic derivative of 6-methylsulfinyl-hexane...

    ≥98%
  • B5871

    Bortezomib

    Proteasome inhibitor.

    ≥98%
  • T286163

    Theaflavin-3,3’-digallate

    Polyphenolic compound present in black tea.

    ≥98%
  • L0528

    LBH-589

    HDAC1/2/3/11 inhibitor.

    ≥98%
  • G7346

    GSK-2636771

    p110β PI3K inhibitor.

    ≥98%
  • L5769

    Lorglumide Sodium

    CCK antagonist.

    ≥98%
  • C6935

    Crizotinib

    ALK, ROS1, c-MET inhibitor.

    ≥98%
  • E5568

    Enramycin A

    Polypeptide; peptidoglycan inhibitor.

    ≥95%
  • T564091

    β-Tocopherol

    Vitamin E component

    ≥98%
  • A5283

    [Sar1]-Angiotensin II

    Peptide, derivative of AT II, involved in vasoc...

    ≥95%
  • E6783

    R-Equol

    Isoflavone, phytoestrogen found in soy

    ≥98%
  • M177521

    Menaquinone-7

    2-methyl-1,4-naphthoquinone derivative

    98%
  • J6400

    (+)-JQ-1

    Triazolothienodiazepine; BRD inhibitor.

    ≥99%
  • G4480

    Glucagon, human

    Endogenous peptide hormone, counteracts insulin...

    ≥95%
  • T5609

    β-Tocotrienol

    Antioxidant, vitamin E derivative found in vege...

    ≥98%
  • L186858

    Levomefolic acid

    Folic acid derivative

    ≥98%
  • C2957

    Cholesterol

    Endogenous sterol component of animal cell memb...

    ≥97%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only