Histrelin Acetate

Product ID H3277

Cas No. 76712-82-8

Purity ≥95%

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Histrelin is an anti-estrogen, anti-testosterone analog of gonadotropin-releasing hormone (GnRH) or luteinizing hormone releasing hormone (LHRH). Histrelin binds and activates the GnRH/LHRH receptor, initially stimulating release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), but then inducing desensitization and decreasing levels of these hormones over long-term administration. Histrelin is clinically used to treat precocious puberty and to suppress estrogen and testosterone levels in prostate cancer patients.

Product Info

Cas No.	76712-82-8
Purity	≥95%
Formula	C₆₆H₈₆N₁₈O₁₂
Formula Wt.	1323.52
IUPAC Name	(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-3-(1-benzylimidazol-4-yl)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
Synonym	[des-Gly 10, D-His(Bzl) 6]-LH-RH ethylamide
Solubility	Soluble in DMSO.

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	H3277 MSDS PDF
Info Sheet	H3277 Info Sheet PDF

References

Lewis KA, Goldyn AK, West KW, et al. A single histrelin implant is effective for 2 years for treatment of central precocious puberty. J Pediatr. 2013 Oct;163(4):1214-6. PMID: 23809043.

Shore N, Cookson MS, Gittelman MC. Long-term efficacy and tolerability of once-yearly histrelin acetate subcutaneous implant in patients with advanced prostate cancer. BJU Int. 2012 Jan;109(2):226-32. PMID: 21851539.

Barradell LB, McTavish D. Histrelin. A review of its pharmacological properties and therapeutic role in central precocious puberty. Drugs. 1993 Apr;45(4):570-88. PMID: 7684676.

Gunnet JW, Demarest KT, Hahn DW, et al. Effects of a sustained release formulation of the gonadotrophin-releasing hormone agonist histrelin on serum concentrations of gonadotrophins and oestradiol, and ovarian LH/human chorionic gonadotrophin receptor content in the rat. J Endocrinol. 1991 Nov;131(2):211-8. PMID: 1744568.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Comments
This field is for validation purposes and should be left unchanged.

Histrelin Acetate

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

A-769662

Leptomycin B

Etidronate Disodium

A-779

Fluticasone Propionate

Enrofloxacin

Idarubicin Hydrochloride

Neostigmine Bromide

Kahweol Acetate

Troglitazone

Trazodone Hydrochloride

Desvenlafaxine Succinate Hydrate

Acalabrutinib

Glycitein

BKM120

Chenodeoxycholic Acid

Carboplatin

17-α-Ethynylestradiol

Bupropion Hydrochloride

Itraconazole

Footer