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HU 308 is a selective cannabinoid receptor 2 (CB2) agonist. Activation of the CB2 receptor produces a variety of results in cancer, neuroscience and immunology. Recent studies with HU 308 show activity in immunomodulatory systems. HU 308, in neuroprogentor cells, induces cellular motility by activation of the PI3-K/Akt/mTORC pathway. HU-308 activates macrophage chemotaxis, albeit without activity the CB2 receptor.
| Cas No. | 256934-39-1 |
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| Purity | ≥98% |
| Formula | C27H42O3 |
| Formula Wt. | 414.63 |
| Chemical Name | [(1R,2S,5R)-2-[2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl]-6,6-dimethyl-4-bicyclo[3.1.1]hept-3-enyl]methanol |
| IUPAC Name | [(1R,2S,5R)-2-[2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl]-6,6-dimethyl-4-bicyclo[3.1.1]hept-3-enyl]methanol |
| Synonym | HU-308 |
| Solubility | 100mM in DMSO, 100mM in ethanol |
| Appearance | Clear film |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
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| Info Sheet |
Hanus L, Breuer A, Tchilibon S et al. HU-308: a specific agonist for CB(2), a peripheral cannabinoid receptor. Proc Natl Acad Sci USA. 1999 Dec 7;96(25):14228-33. PMID: 10588688.
Palazuelos J, Ortega Z, Diaz-Alonso J et al. CB2 cannabinoid receptors promote neural progenitor cell proliferation via mTORC1 signaling. J Biol Chem. 2012 Jan 6;287(2):1198-209. PMID: 22102284.
Taylor L, Christou I, Kapellos TS, et al. Primary Macrophage Chemotaxis Induced by Cannabinoid Receptor 2 Agonists Occurs Indepenently of the CB2 Receptor. Sci Rep. 2015 Jun 2;5:10682. PMID: 26033291.