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Hydroxyurea

Hydroxyurea

Product ID H9715
Cas No. 127-07-1
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $87.60 In stock
10 g $165.40 In stock
50 g $486.30 In stock
100 g $680.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Hydroxyurea exhibits anticancer chemotherapeutic and antiviral activities; it inhibits ribonucleotide reductase, limiting deoxyribonucleotide production and inhibiting DNA synthesis. This compound also treats sickle cell anemia, as it increases NO levels in blood through binding of hemoglobin and stimulates production of fetal hemoglobin which is not affected by the sickle-cell gene mutation. It also treats myeloproliferative disorders and chronic myelogenous leukemia (CML)

Product Info

Cas No.

127-07-1

Purity

≥98%

Formula

CH4N2O2

Formula Wt.

76.06

IUPAC Name

hydroxyurea

Synonym

Hydroxycarbamide, Droxia, Hydrea, Litalir

Melting Point

133-136°C

Solubility

Soluble in water or hot alcohol.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

H9715 MSDS PDF

Info Sheet

H9715 Info Sheet PDF

References

Amaru Calzada A, Pedrini O, Finazzi G, et al. Givinostat and hydroxyurea synergize in vitro to induce apoptosis of cells from JAK2(V617F) myeloproliferative neoplasm patients. Exp Hematol. 2013 Mar;41(3):253-60.e2. PMID: 23111067.

Vankayala SL, Hargis JC, Woodcock HL. Unlocking the binding and reaction mechanism of hydroxyurea substrates as biological nitric oxide donors. J Chem Inf Model. 2012 May 25;52(5):1288-97. PMID: 22519847.

Custom Order

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