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Hygromycin B

Hygromycin B

Product ID H9726
Cas No. 31282-04-9
Purity ≥95.0%
Product Unit SizeCostQuantityStock
50 mg $58.50 In stock
100 mg $84.30 In stock
250 mg $97.30 In stock
1 g $194.70 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Hygromycin B is an antibiotic that also displays antiviral activity. Hygromycin binds the 30S ribosomal subunit, inhibiting protein and RNA synthesis of bacteria or viruses; it induces misreadings at multiple steps in protein translation and suppresses translocation. In animal models, hygromycin B allows translation to occur but prevents formation of viral antigen by Leishmania and, separately, prevents infection by murine hepatitis virus.

Product Info

Cas No.

31282-04-9

Purity

≥95.0%

Formula

C20H37N3O13

Formula Wt.

527.52

Chemical Name

(2S,3'R,3aS,4S,4'S,5'R,6R,6'R,7S,7aS)-4-[(1R,2S,3R,5S,6R)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy-6'-[(1R)-1-amino-2-hydroxyethyl]-6-(hydroxymethyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2,2'-oxane]-3',4',5',7-tetrol

IUPAC Name

4-[3-amino-2, 6-dihydroxy-5-(methylamino)cyclohexyl]oxy-6'-(1-amino-2-hydroxyethyl)-6- (hydroxymethyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2, 2'-oxane]-3',4',5',7-tetrol

Synonym

Hygrovetine

Appearance

Buff Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

H9726 MSDS PDF

Info Sheet

H9726 Info Sheet PDF

References

Brodersen DE, Clemons WM Jr, Carter AP, et al. The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit. Cell. 2000 Dec 22;103(7):1143-54. PMID: 11163189.

Ro YT, Scheffter SM, Patterson JL. Hygromycin B resistance mediates elimination of Leishmania virus from persistently infected parasites. J Virol. 1997 Dec;71(12):8991-8. PMID: 9371555.

Macintyre G, Woods DE, Anderson R. Hygromycin B inhibits synthesis of murine coronavirus RNA. Antimicrob Agents Chemother. 1991 Dec;35(12):2630-3. PMID: 1667257.

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