LKT Labs

Biochemicals for Life Science Research

I-BET-762

I-BET-762

Product ID I0518
Cas No. 1260907-17-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $75.00 In stock
5 mg $150.00 In stock
10 mg $263.00 In stock
25 mg $549.00 In stock
Bulk Quote

Quicklinks

Description

I-BET-762 is a BET bromodomain (BRD) inhibitor that prevents association of BRDs with chromatin histones; it exhibits immunosuppressive, anticancer, and anti-inflammatory activities. In animal models of experimental autoimmune encephalitis (EAE), I-BET-762 decreases production of pro-inflammatory cytokines, increases production of anti-inflammatory cytokines, and prevents antigen-specific T cell induction of pathogenesis. This compound also inhibits proliferation of B-cell acute lymphoblastic leukemia cells.

Product Info

Cas No.

1260907-17-2
Purity

≥98%
Formula

C22H22ClN5O2
Formula Wt.

423.90
Chemical Name

2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide
IUPAC Name

2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide
Synonym

GSK525762
Solubility

DMSO 84 mg/mL (198.15 mM) Ethanol 42 mg/mL warmed (99.07 mM) Water Insoluble
Appearance

Off white (Beige) Powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

I0518 MSDS PDF
Info Sheet

I0518 Info Sheet PDF

References

Ma S, Chen C, Zhu J, et al. In vitro study of BRD4 inhibitor GSK525762A against primary adult common B-cell acute lymphoblastic leukemia cells in vitro. Zhonghua Xue Ye Xue Za Zhi. 2015 Jul 14;36(7):563-9. PMID: 26304078.

Bandukwala HS, Gagnon J, Togher S, et al. Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14532-7. PMID: 22912406.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • R0249

    Ramipril

    ACE inhibitor.

    ≥98%
  • L3456

    γ-Linolenic Acid (6c, 9c, 12c)

    Omega-6 fatty acid found in vegetable oils; PPA...

    ≥98%
  • S9753

    Synephrine

    Endogenous alkaloid also found in citrus fruits...

    ≥98%
  • A6827

    Argipressin Acetate

    Endogenous peptide, involved in vascular contra...

    ≥95%
  • S8245

    Sulfadiazine

    Sulfonamide; folate production inhibitor.

    ≥98%
  • U6858

    Urocortin II, mouse

    Endogenous peptide, involved in stress signalin...

    ≥95%
  • N3452

    Nimustine Hydrochloride

    Nitrosourea, DNA cross-linker.

    ≥97%
  • N176498

    Nemorosone

    Found in the propolis of honey bees.

    ≥99%
  • B8377

    5-tert-Butoxyquinazoline-2,4-diamine

    Diaminoquinazoline derivative.

    ≥98%
  • S8251

    Sulfluramid

    Perfluorinated insecticide.

    ≥95%
  • F4557

    Floxuridine

    5-Fluorouracil derivative, fluorinated pyrimidi...

    ≥98%
  • P7359

    Psoralidin

    Phenol found in Psoralea coryfolia.

    ≥98%
  • L5822

    Lofexidine Hydrochloride

    α2-adrenergic agonist.

    ≥98%
  • T0090

    7-(Triethylsilyl)-baccatin III

    Synthetic taxol synthesis intermediate; microtu...

    ≥98%
  • C0154

    7-Ethyl-10-hydroxycamptothecin

    Camptothecin derivative; topoisomerase I inhibi...

    ≥98%
  • M177521

    Menaquinone-7

    2-methyl-1,4-naphthoquinone derivative

    98%
  • C0016

    Caerulomycin A

    Bipyridamine toxin.

    ≥96%
  • H1658

    Heparin Sodium

    Endogenous glycosaminoglycan that is produced b...

    Bioassay ≥140 U/mg
  • A145823

    ADU-S100 sodium salt

    Synthetic cyclic dinucleotide agonist of STING....

    ≥99%
  • S6168

    Spirapril Hydrochloride

    ACE inhibitor.

    ≥98%