LKT Labs

Biochemicals for Life Science Research

I-BET-762

I-BET-762

Product ID I0518
Cas No. 1260907-17-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $75.00 In stock
5 mg $150.00 In stock
10 mg $263.00 In stock
25 mg $549.00 In stock
Bulk Quote

Quicklinks

Description

I-BET-762 is a BET bromodomain (BRD) inhibitor that prevents association of BRDs with chromatin histones; it exhibits immunosuppressive, anticancer, and anti-inflammatory activities. In animal models of experimental autoimmune encephalitis (EAE), I-BET-762 decreases production of pro-inflammatory cytokines, increases production of anti-inflammatory cytokines, and prevents antigen-specific T cell induction of pathogenesis. This compound also inhibits proliferation of B-cell acute lymphoblastic leukemia cells.

Product Info

Cas No.

1260907-17-2
Purity

≥98%
Formula

C22H22ClN5O2
Formula Wt.

423.90
Chemical Name

2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide
IUPAC Name

2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide
Synonym

GSK525762
Solubility

DMSO 84 mg/mL (198.15 mM) Ethanol 42 mg/mL warmed (99.07 mM) Water Insoluble
Appearance

Off white (Beige) Powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

I0518 MSDS PDF
Info Sheet

I0518 Info Sheet PDF

References

Ma S, Chen C, Zhu J, et al. In vitro study of BRD4 inhibitor GSK525762A against primary adult common B-cell acute lymphoblastic leukemia cells in vitro. Zhonghua Xue Ye Xue Za Zhi. 2015 Jul 14;36(7):563-9. PMID: 26304078.

Bandukwala HS, Gagnon J, Togher S, et al. Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14532-7. PMID: 22912406.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • K0021

    K252a

    Staurosporine analog; PKC inhibitor, TrkA/B ant...

    ≥98%
  • D582705

    Dorsomorphin Dihydrochloride

    Inhibitor of ALK2, ALK3, ALK6, and AMPK.

    ≥98%
  • H3278

    HIV Reverse Transcriptase A2.1 Peptide

    Peptide, HIV-1 RT A2.1 epitope.

    ≥95%
  • R0105

    Rabeprazole Sodium

    H+/K+ ATPase and Scpc phosphatase inhibitor.

    ≥98%
  • G0048

    γ-Amino Butyric Acid

    Endogenous neurotransmitter; GABA agonist.

    ≥99%
  • O486179

    Omeprazole Impurity C

    Impurity of omeprazole

    ≥99%
  • E5210

    Endomorphin-1

    Endogenous opioid peptide; μOr agonist.

    ≥95%
  • A1016

    S-Acetyl-L-glutathione

    Alters intracellular glutathione levels.

    ≥98%
  • T1025

    D-Seco Paclitaxel

    D-Seco Paclitaxel is an impurity in the product...

    ≥90%
  • A4000

    AK-1

    SIRT2 inhibitor.

    ≥99%
  • E8419

    Everolimus

    mTORC1 inhibitor.

    ≥98%
  • O486180

    Omeprazole Related Compound A

    Impurity of omeprazole

    ≥99%
  • P327212

    Pifithrin-α-cyclic Hydrobromide

    p53 inhibitor

    ≥98%
  • B6857

    4’-Bromoflavone

    Nrf2-Keap1-ARE complex activator.

    ≥98%
  • H1695

    S-Hexylglutathione

    Glutathione-S-transferase inhibitor.

    ≥98%
  • T7134

    trans-3,4′,5-Trimethoxy Stilbene

    Resveratrol prodrug; potential SIRT1 activator....

    ≥99%
  • S1845

    L-(+)-Selenomethionine

    Naturally occurring amino acid found in grains,...

    ≥98%
  • W0272

    S-(−)-Warfarin >99%ee

    Coumarin, more potent isomer; VKORC1 inhibitor....

    ≥99%
  • O7377

    Osthole

    O-methylated coumarin; Ca2+ channel blocker.

    ≥98%
  • D1695

    Dexamethasone Phosphate Sodium

    Steroid; glucocorticoid agonist.

    ≥98%