LKT Labs

Biochemicals for Life Science Research

I-BET-762

I-BET-762

Product ID I0518
Cas No. 1260907-17-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $75.00 In stock
5 mg $150.00 In stock
10 mg $263.00 In stock
25 mg $549.00 In stock
Bulk Quote

Quicklinks

Description

I-BET-762 is a BET bromodomain (BRD) inhibitor that prevents association of BRDs with chromatin histones; it exhibits immunosuppressive, anticancer, and anti-inflammatory activities. In animal models of experimental autoimmune encephalitis (EAE), I-BET-762 decreases production of pro-inflammatory cytokines, increases production of anti-inflammatory cytokines, and prevents antigen-specific T cell induction of pathogenesis. This compound also inhibits proliferation of B-cell acute lymphoblastic leukemia cells.

Product Info

Cas No.

1260907-17-2
Purity

≥98%
Formula

C22H22ClN5O2
Formula Wt.

423.90
Chemical Name

2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide
IUPAC Name

2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide
Synonym

GSK525762
Solubility

DMSO 84 mg/mL (198.15 mM) Ethanol 42 mg/mL warmed (99.07 mM) Water Insoluble
Appearance

Off white (Beige) Powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

I0518 MSDS PDF
Info Sheet

I0518 Info Sheet PDF

References

Ma S, Chen C, Zhu J, et al. In vitro study of BRD4 inhibitor GSK525762A against primary adult common B-cell acute lymphoblastic leukemia cells in vitro. Zhonghua Xue Ye Xue Za Zhi. 2015 Jul 14;36(7):563-9. PMID: 26304078.

Bandukwala HS, Gagnon J, Togher S, et al. Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14532-7. PMID: 22912406.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T5870

    Torin 1

    Tricyclic benzonaphthyridinone; mTORC1/2 inhibi...

    ≥98%
  • G0000

    G250.A2 Peptide

    Peptide, carbonic anhydrase G250 epitope.

    ≥95%
  • I7659

    1-Isothiocyanato-8-(methylsulfonyl)-octane

    ITC, erysolin analog.

    ≥98%
  • S680017

    SR-717 Lithium Salt

    STING agonist

    ≥98%
  • B1879

    Betamethasone Valerate

    Synthetic steroid hormone; glucocorticoid agoni...

    ≥98%
  • B3280

    Bis(salicyl) Fumarate

    Aspirin analog; hemoglobin chain cross-linker.<...

    ≥98%
  • G3356

    Ginkgolide AB

    Mixture of terpene lactones found in Ginkgo.

    ≥98%
  • T0096

    Cephalomannine

    Diterpene found in Taxus; potential microtubule...

    ≥98%
  • K624760

    KPT-276

    CRM1/XPO1 inhibitor.

    ≥99%
  • P0344

    Palbociclib Isethionate

    CDK4/6 inhibitor.

    ≥98%
  • C8502

    CV-70

    1,8-Diaza-anthracene-tetrone; JNK and ERK5 inhi...

    ≥70%
  • V5725

    Voglibose

    α-glucosidase inhibitor, potential GLP-1 agoni...

    ≥99%
  • D3372

    Disodium Cycloheptylaminomethylene Diphosphate

    Bisphosphonate; squalene synthase inhibitor.

    ≥98%
  • M2409

    MGCD-0103

    HDAC inhibitor.

    ≥98%
  • B1878

    Betamethasone 21-Phosphate Sodium

    Steroid; glucocorticoid agonist.

    ≥98%
  • N1980

    Neuromedin B, pig

    Endogenous bombesin-related peptide, involved i...

    ≥95%
  • P1853

    Penicillin V Potassium

    Hydrophobic β-lactam; penicillin binding prote...

    ≥98%
  • N5655

    Nonoxynol-9

    Nonoxynol surfactant.

    90-110%
  • G3458

    Ginsenoside Rg1

    Triterpene saponin found in species of Panax.

    ≥98%
  • B3577

    Bitertanol

    Pesticide; demethylation inhibitor.

    ≥98%