LKT Labs

Biochemicals for Life Science Research

I-BET-762

I-BET-762

Product ID I0518
Cas No. 1260907-17-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $75.00 In stock
5 mg $150.00 In stock
10 mg $263.00 In stock
25 mg $549.00 In stock
Bulk Quote

Quicklinks

Description

I-BET-762 is a BET bromodomain (BRD) inhibitor that prevents association of BRDs with chromatin histones; it exhibits immunosuppressive, anticancer, and anti-inflammatory activities. In animal models of experimental autoimmune encephalitis (EAE), I-BET-762 decreases production of pro-inflammatory cytokines, increases production of anti-inflammatory cytokines, and prevents antigen-specific T cell induction of pathogenesis. This compound also inhibits proliferation of B-cell acute lymphoblastic leukemia cells.

Product Info

Cas No.

1260907-17-2
Purity

≥98%
Formula

C22H22ClN5O2
Formula Wt.

423.90
Chemical Name

2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide
IUPAC Name

2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide
Synonym

GSK525762
Solubility

DMSO 84 mg/mL (198.15 mM) Ethanol 42 mg/mL warmed (99.07 mM) Water Insoluble
Appearance

Off white (Beige) Powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

I0518 MSDS PDF
Info Sheet

I0518 Info Sheet PDF

References

Ma S, Chen C, Zhu J, et al. In vitro study of BRD4 inhibitor GSK525762A against primary adult common B-cell acute lymphoblastic leukemia cells in vitro. Zhonghua Xue Ye Xue Za Zhi. 2015 Jul 14;36(7):563-9. PMID: 26304078.

Bandukwala HS, Gagnon J, Togher S, et al. Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14532-7. PMID: 22912406.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • B5044

    BML-277

    Arylbenzimidazole; CHK2 inhibitor.

    ≥98%
  • R3220

    Rifampicin

    Ansamycin; bacterial DNA-dependent RNA polymera...

    ≥98%
  • S771339

    STING Agonist-12

    STING activator

    ≥99%
  • M403007

    MK-3697

    Orexin 2 receptor antagonist

    ≥98%
  • F4581

    5-Fluorocytosine

    Synthetic antifungal.

    ≥98%
  • C3374

    Cisplatin

    Pt-based DNA cross-linker.

    ≥99%
  • F3207

    Fibronectin CS-1 Peptide

    Peptide; α4β1 integrin activator.

    ≥95%
  • A985120

    AZD-0156

    Inhibitor of ATM.

    ≥98%
  • B6801

    Brassinin

    Phytoalexin, indole found in cruciferous vegeta...

    ≥98%
  • B1603

    Beauvericin

    Cyclic hexadepsipeptide mycotoxin produced by C...

    ≥95%
  • T6930

    Triclosan Methyl Ether

    Diarylether; bacterial ENR binder, fatty acid s...

    ≥99%
  • C2997

    Chymostatin

    Protease inhibitor.

    ≥95% (mixture of A, B, C)
  • L1852

    Lenalidomide

    Thalidomide derivative; cereblon and TNF-α inh...

    ≥98%
  • R0020

    RAF265

    B-Raf, VEGFR2, c-Raf, PDGFR, CSF-1R, RET, c-Kit...

    ≥98%
  • B1652

    Benzo[a]pyrene

    Polycyclic aromatic hydrocarbon (PAH) found in ...

    ≥98%
  • L5870

    Lornoxicam

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • N4524

    NLG919

    Indoleamine-2,3-dioxygenase inhibitor.

    ≥98%
  • P337538

    (-)-Pinostrobin

    Neuroprotective flavonoid

    ≥99%
  • M5756

    Montelukast Sodium

    CysLT1 antagonist.

    ≥98%
  • N3346

    Nilotinib

    Phenylamino pyridine; Abl, c-Kit, PDGFR, PP2A i...

    ≥99%