LKT Labs

Biochemicals for Life Science Research

I-BET-762

I-BET-762

Product ID I0518
Cas No. 1260907-17-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $75.00 In stock
5 mg $150.00 In stock
10 mg $263.00 In stock
25 mg $549.00 In stock
Bulk Quote

Quicklinks

Description

I-BET-762 is a BET bromodomain (BRD) inhibitor that prevents association of BRDs with chromatin histones; it exhibits immunosuppressive, anticancer, and anti-inflammatory activities. In animal models of experimental autoimmune encephalitis (EAE), I-BET-762 decreases production of pro-inflammatory cytokines, increases production of anti-inflammatory cytokines, and prevents antigen-specific T cell induction of pathogenesis. This compound also inhibits proliferation of B-cell acute lymphoblastic leukemia cells.

Product Info

Cas No.

1260907-17-2
Purity

≥98%
Formula

C22H22ClN5O2
Formula Wt.

423.90
Chemical Name

2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide
IUPAC Name

2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide
Synonym

GSK525762
Solubility

DMSO 84 mg/mL (198.15 mM) Ethanol 42 mg/mL warmed (99.07 mM) Water Insoluble
Appearance

Off white (Beige) Powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

I0518 MSDS PDF
Info Sheet

I0518 Info Sheet PDF

References

Ma S, Chen C, Zhu J, et al. In vitro study of BRD4 inhibitor GSK525762A against primary adult common B-cell acute lymphoblastic leukemia cells in vitro. Zhonghua Xue Ye Xue Za Zhi. 2015 Jul 14;36(7):563-9. PMID: 26304078.

Bandukwala HS, Gagnon J, Togher S, et al. Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14532-7. PMID: 22912406.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • M1879

    Metoprolol Tartrate

    β1-adrenergic antagonist.

    ≥98%
  • M1975

    S-(N-Methylthiocarbamoyl)-L-cysteine

    Cysteine-ITC conjugate, antioxidant; aldehyde d...

    ≥98%
  • T3584

    Tivantinib

    MET and GSK-3α/β inhibitor.

    ≥98%
  • D5747

    Dolasetron Mesylate Hydrate

    5-HT3 antagonist.

    ≥98%
  • R3222

    Rifamycin SV Monosodium

    Ansamycin; bacterial DNA-dependent RNA polymera...

    ≥98%
  • C9778

    Cytarabine

    Pyrimidine nucleoside (cytidine) analog; DNA ch...

    ≥98%
  • C4510

    Climbazole

    14-α demethylase inhibitor.

    ≥99%
  • A0961

    Adrenocorticotropic Hormone (1-39), rat

    Endogenous peptide hormone, involved in stress ...

    ≥95%
  • M1678

    2-Methoxyestradiol

    Estradiol metabolite; microtubule depolymerizat...

    ≥98%
  • M177521

    Menaquinone-7

    2-methyl-1,4-naphthoquinone derivative

    98%
  • D5662

    Dopamine Hydrochloride

    Endogenous hormone neurotransmitter, involved i...

    ≥99%
  • Z5653

    Zonisamide

    Sulfonamide; carbonic anhydrase inhibitor, volt...

    ≥96%
  • B4796

    BLZ-945

    CSF-1R Inhibitor.

    ≥95%
  • D1628

    5,6-Dehydrokawain

    Kavalactone originally found in Piper methystic...

    ≥98%
  • B1979

    Betulinic Acid

    Pentacyclic triterpene.

    ≥99%
  • A7204

    AS-605240

    p110δ PI3K inhibitor.

    ≥98%
  • R3014

    Recombinant TpN 47 protein

    Recombinant protein containing Treponema pallid...

    ≥95%
  • R0351

    Ramoplanin

    Peptide; peptidoglycan inhibitor.

    ≥90%
  • Z5645

    Zoledronate Disodium Tetrahydrate

    Bisphosphonate; FPPS inhibitor.

    ≥98%
  • E6896

    Erysolin

    ITC found in cruciferous vegetables, analog of ...

    ≥97%