I-BET-762

Name: I-BET-762
SKU: I0518
Availability: InStock

Product ID I0518

Cas No. 1260907-17-2

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

I-BET-762 is a BET bromodomain (BRD) inhibitor that prevents association of BRDs with chromatin histones; it exhibits immunosuppressive, anticancer, and anti-inflammatory activities. In animal models of experimental autoimmune encephalitis (EAE), I-BET-762 decreases production of pro-inflammatory cytokines, increases production of anti-inflammatory cytokines, and prevents antigen-specific T cell induction of pathogenesis. This compound also inhibits proliferation of B-cell acute lymphoblastic leukemia cells.

Product Info

Cas No.	1260907-17-2
Purity	≥98%
Formula	C₂₂H₂₂ClN₅O₂
Formula Wt.	423.90
Chemical Name	2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide
IUPAC Name	2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide
Synonym	GSK525762
Solubility	DMSO 84 mg/mL (198.15 mM) Ethanol 42 mg/mL warmed (99.07 mM) Water Insoluble
Appearance	Off white (Beige) Powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	I0518 MSDS PDF
Info Sheet	I0518 Info Sheet PDF

References

Ma S, Chen C, Zhu J, et al. In vitro study of BRD4 inhibitor GSK525762A against primary adult common B-cell acute lymphoblastic leukemia cells in vitro. Zhonghua Xue Ye Xue Za Zhi. 2015 Jul 14;36(7):563-9. PMID: 26304078.

Bandukwala HS, Gagnon J, Togher S, et al. Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14532-7. PMID: 22912406.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Email
This field is for validation purposes and should be left unchanged.

I-BET-762

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

5-Fluorocytosine

JTE907

Flavopiridol Hydrochloride

Doxapram Hydrochloride Hydrate

C-178

Prednisolone Sodium Phosphate

Tivozanib

Diclofenac Sodium

2′,7-bis(triethylsilyl)taxol

Acemetacin

Levomefolic acid calcium salt

CEP-28122 Mesylate

Prion Peptide (106-126), human

L-Citrulline

Brompheniramine Maleate

α-Zearalanol

[Sar9]-Substance P

STING Agonist-12

Hydrolyzed Fumonisin B1

PluriSIn 1

Footer