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Isradipine

Isradipine

Product ID I7468
Cas No. 75695-93-1
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $63.00 In stock
25 mg $157.50 In stock
50 mg $304.50 In stock
250 mg $367.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
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  • References
  • Description
  • Product Info
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Description

Isradipine is a second-generation dihydropyridine calcium channel blocker. It has been found to protect against stroke and brain ischemia in rat models of hypertension. Research has also shown that isradipine influences amyloid-beta production in addition to components of the cav1.2-ptau-autophagy pathway and thereby may be useful in the treatment of Alzheimer’s disease. Furthermore, it has been found to protect striatal dopaminergic terminals and parent substantia nigra pars compacta cell bodies against intrastriatal injection of the toxin 6-hydroxydopamine, and so may also be an effective treatment of Parkinson’s disease.

Product Info

Cas No.

75695-93-1

Purity

≥98%

Formula

C19H21N3O5

Formula Wt.

371.39

Chemical Name

3-O-methyl 5-O-propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

IUPAC Name

4-(2,1,3-Benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydro-3-isopropyloxycarbonylpyridine-5-carboxylic Acid Methyl Ester

Synonym

DynaCirc, Isradipin, Lomir

Solubility

DMSO 200mM Ethanol 200mM Water Insoluble

Appearance

Yellow crystalline powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

I7468 MSDS PDF

Info Sheet

I7468 Info Sheet PDF

References

Lee HA, Hyun SA, Park SG, et al. Comparison of electrophysiological effects of calcium channel blockers on cardiac repolarization. Korean J Physiol Pharmacol. 2016 Jan; 20(1):119-127. PMID: 26807031.

Anekonda TS, Quinn JF. Calcium channel blocking as a therapeutic strategy for Alzheimer’s disease: the case for isradipine. Biochim Biophys Acta. 2011 Dec; 1812(12): 1584-1590. PMID: 21925266.

Ilijic E, Guzman JN, Surmeier DJ. The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson’s disease. Neurobiol Dis. 2011 Aug; 43(2): 364-371. PMID: 21515375.

Custom Order

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