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JH-II-127

JH-II-127

Product ID J291331
Cas No. 1700693-08-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $61.40 In stock
5 mg $156.80 In stock
25 mg $511.10 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

JH-II-127 is a selective inhibitor of leucine-rich repeat kinase 2 (LRRK2), a potential therapeutic target for neurodegenerative disease. It inhibits phosphorylation of Ser910 and Ser935 in both wild-type LRRK2 and the G2019S mutant.

Product Info

Cas No.

1700693-08-8

Purity

≥98%

Formula

C19H21ClN6O3

Formula Wt.

416.87

IUPAC Name

(4-{[5-Chloro-4-(methylamino)-3H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-3-methoxyphenyl)(4-morpholinyl)methanone

Synonym

Pyrrolopyrimidine

Solubility

DMSO

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

J291331 MSDS PDF

Info Sheet

J291331 Info Sheet PDF

References

Hatcher J., Zhang J., et al. Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor. ACS Med Chem Lett. 6(5):584-9 (2015). PMID: 26005538.

Custom Order

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