Description
JH-II-127 is a selective inhibitor of leucine-rich repeat kinase 2 (LRRK2), a potential therapeutic target for neurodegenerative disease. It inhibits phosphorylation of Ser910 and Ser935 in both wild-type LRRK2 and the G2019S mutant.
| Product Unit Size | Cost | Quantity | Stock |
|---|
JH-II-127 is a selective inhibitor of leucine-rich repeat kinase 2 (LRRK2), a potential therapeutic target for neurodegenerative disease. It inhibits phosphorylation of Ser910 and Ser935 in both wild-type LRRK2 and the G2019S mutant.
| Cas No. | 1700693-08-8 |
|---|---|
| Purity | ≥98% |
| Formula | C19H21ClN6O3 |
| Formula Wt. | 416.87 |
| IUPAC Name | (4-{[5-Chloro-4-(methylamino)-3H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-3-methoxyphenyl)(4-morpholinyl)methanone |
| Synonym | Pyrrolopyrimidine |
| Solubility | DMSO |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Hatcher J., Zhang J., et al. Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor. ACS Med Chem Lett. 6(5):584-9 (2015). PMID: 26005538.
Steroidal alkaloid found in Fritillaria; TRPV1 ...
STING activator
Thienylbutyl ITC analog.
p110γ PI3K inhibitor.
Kavalactone originally found in Piper methystic...
Endogenous cardiomodulatory peptide; NPR-A agon...
Calpain I/II inhibitor.
Echinocandin antifungal
Isoflavonoid found in Glycyrrhiza; GABA-A posit...
Hedgehog and Smo agonist.
Endogenous peptide hormone, involved in stress ...
2-methyl-1,4-naphthoquinone derivative
Tretinoin analog; RARα/β/γ agonist.
Dihydrofolate reductase inhibitor.
DAT inhibitor.
Diterpene compound originally found in Rosmarin...
p110α PI3K inhibitor.
SERM.
Cyclic tetrapeptide; HDAC inhibitor.
Isoquinoline alkaloid found in Corydalis; 5-HT1...