• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
JH-II-127

JH-II-127

Product ID J291331
Cas No. 1700693-08-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $61.00 In stock
5 mg $157.00 In stock
25 mg $511.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

JH-II-127 is a selective inhibitor of leucine-rich repeat kinase 2 (LRRK2), a potential therapeutic target for neurodegenerative disease. It inhibits phosphorylation of Ser910 and Ser935 in both wild-type LRRK2 and the G2019S mutant.

Product Info

Cas No.

1700693-08-8

Purity

≥98%

Formula

C19H21ClN6O3

Formula Wt.

416.87

IUPAC Name

(4-{[5-Chloro-4-(methylamino)-3H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-3-methoxyphenyl)(4-morpholinyl)methanone

Synonym

Pyrrolopyrimidine

Solubility

DMSO

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

J291331 MSDS PDF

Info Sheet

J291331 Info Sheet PDF

References

Hatcher J., Zhang J., et al. Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor. ACS Med Chem Lett. 6(5):584-9 (2015). PMID: 26005538.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • V5254

    Vincristine Sulfate

    Vinca alkaloid found in Catharanthus; microtubu...

    ≥98%
  • T0090

    7-(Triethylsilyl)-baccatin III

    Synthetic taxol synthesis intermediate; microtu...

    ≥98%
  • C0800

    C59

    PORCN inhibitor.

    ≥98%
  • C4558

    Clonidine Hydrochloride

    Imidazoline and α2-adrenergic agonist, Nav1.7 ...

    ≥98%
  • N8277

    Nutlin-3

    Imidzoline derivative; MDM2 inhibitor.

    ≥95%
  • A2244

    Aflatoxicol

    Mycotoxin, metabolite of aflatoxin B1 produced ...

    ≥98%
  • R8076

    Rutin Hydrate

    Flavonoid glycoside found in fruit, asparagus, ...

    ≥95%
  • P0932

    PCI-32765

    BTK and IL-2-inducible kinase inhibitor.

    ≥99%
  • S8247

    Sulfasalazine

    Mesalazine derivative, sulfa drug; sepiapterin ...

    ≥98%
  • P7057

    Protodioscin

    Saponin found in Dioscorea; Na+/K+ ATPase and C...

    ≥98%
  • O9596

    Oxybutynin Hydrochloride

    mAChR antagonist.

    ≥98%
  • B4517

    Bleomycin A5 Hydrochloride

    Glycopeptide, induces DNA strand breaks.

    ≥90%
  • R2511

    RGDC

    Peptide, used to study cell-surface binding; po...

    ≥95%
  • M5753

    Monensin Sodium

    Polyether ionophore, autophagy inhibitor.

    ≥98%
  • P3576

    Pitavastatin Calcium

    Statin; HMG-CoA reductase inhibitor.

    ≥98%
  • R2400

    RG-108

    DNMT inhibitor.

    ≥98%
  • L3455

    α-Linolenic Acid

    An omega-3 fatty acid.

    ≥98%
  • B5074

    BMS-599626

    EGFR, VEGFR inhibitor.

    ≥98%
  • M0113

    Madecassoside

    Triterpenoid found in Centella.

    ≥90%
  • E6396

    EPZ005687

    EZH2 HMT inhibitor.

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2026 LKT Laboratories, All Rights Reserved - Products for research use only