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Kallikrein inhibitor is a serine protease inhibitor that inhibits kallikrein and plasmin. Kallikrein inhibitor may exhibit anticancer chemotherapeutic benefit and may also be used as a treatment for angioedema. In various cancer cell lines, kallikrein inhibitor alters membrane potential and increases intracellular Ca2+, inhibiting cell proliferation.
| Cas No. | 97145-43-2 |
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| Purity | ≥95% |
| Formula | C35H55N11O9 |
| Formula Wt. | 773.9 |
| IUPAC Name | (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-acetylpyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-hydroxypropanoyl]amino]-3-methylbutanoyl]amino]pentanediamide |
| Synonym | KKI 5, Ac-PFRSVQ-NH2 |
| Solubility | Soluble in DMSO. |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Bilgin M, Burgazli KM, Rafiq A, et al. Effect of bauhinia bauhinioides kallikrein inhibitor on endothelial proliferation and intracellular calcium concentration. Eur Rev Med Pharmacol Sci. 2014 Jan;18(1):46-51. PMID: 24452941.
Nakahata AM, Mayer B, Neth P, et al. Blocking the proliferation of human tumor cell lines by peptidase inhibitors from Bauhinia seeds. Planta Med. 2013 Mar;79(3-4):227-35. PMID: 23345168.
Levy JH, O'Donnell PS. The therapeutic potential of a kallikrein inhibitor for treating hereditary angioedema. Expert Opin Investig Drugs. 2006 Sep;15(9):1077-90. PMID: 16916274.